T. Strecker

发表

Dietary energy restriction inhibits estrogen-induced mammary, but not pituitary, tumorigenesis in the ACI rat.

J. Shull, K. Pennington, D. M. Harvell, 2002, Carcinogenesis.

Diet-gene interactions in estrogen-induced mammary carcinogenesis in the ACI rat.

J. Shull, D. M. Harvell, R. Mccomb, 2001, The Journal of nutrition.

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L.

M. Horsman, D. Chaplin, M. L. Trawick, 2012, European journal of medicinal chemistry.

Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption.

J. Shull, D. Birt, T. Spady, 1999, The Journal of nutrition.

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

D. Chaplin, B. Siim, M. L. Trawick, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.

M. L. Trawick, John J. Hall, K. Pinney, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.

Zhe Shi, D. Chaplin, M. L. Trawick, 2017, Bioorganic & medicinal chemistry letters.

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

R. Mason, D. Chaplin, E. Hamel, 2013, Journal of natural products.

Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.

E. Hamel, M. L. Trawick, R. Tanpure, 2009, Bioorganic & medicinal chemistry.

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.

R. Mason, D. Saha, D. Chaplin, 2019, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.

R. Mason, D. Chaplin, E. Hamel, 2016, Bioorganic & medicinal chemistry.

The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors

P. Brown, T. Krisko, Q. Shen, 2008, Oncogene.

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.

Ashleigh L. Barnes, M. Horsman, D. Chaplin, 2015, Bioorganic & medicinal chemistry.

Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

D. Chaplin, G. Pettit, M. L. Trawick, 2008, Bioorganic & medicinal chemistry letters.

Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1.

D. Chaplin, B. Siim, M. L. Trawick, 2010, Journal of natural products.

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

T. E. Strecker, E. Hamel, M. L. Trawick, 2019, MedChemComm.

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.

R. Mason, D. Chaplin, Heling Zhou, 2018, MedChemComm.

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006).

D. Chaplin, E. Hamel, M. L. Trawick, 2013, Bioorganic & medicinal chemistry.

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.

R. Mason, D. Chaplin, E. Hamel, 2015, Bioorganic & medicinal chemistry.

Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat

J. Shull, K. Gould, K. K. Hansen, 2006, Mammalian Genome.

Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.

J. Meza, J. Shull, B. Schaffer, 2006, Cancer research.

Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains.

J. Shull, T. Spady, M. Snyder, 2001, Endocrinology.

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.

Alejandro J. Ramirez, R. Mason, Zhe Shi, 2020, Journal of natural products.

Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers.

J. Shull, S. Roy, K. Pennington, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14

J. Meza, J. Shull, B. Schaffer, 2006, Mammalian Genome.

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.

R. Mason, D. Chaplin, T. E. Strecker, 2016, MedChemComm.

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.

D. Chaplin, M. L. Trawick, R. Tanpure, 2013, Bioorganic & medicinal chemistry.

Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.

D. Chaplin, E. Hamel, B. Siim, 2011, Journal of natural products.

An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.

D. Chaplin, E. Hamel, M. L. Trawick, 2012, MedChemComm.

Genetic Bases of Estrogen-Induced Pituitary Tumorigenesis

J. Meza, J. Shull, M. T. McLaughlin, 2005, Genetics.

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.

R. Mason, D. Chaplin, Li Li, 2015, Cancer letters.

Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN × ACI intercross

J. Shull, B. Schaffer, K. Pennington, 2007, Mammalian Genome.

Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice.

S. Hilsenbeck, C. Osborne, P. Brown, 2009, Journal of the National Cancer Institute.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

D. Chaplin, B. Siim, M. L. Trawick, 2010, Bioorganic & Medicinal Chemistry Letters.

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L.

M. Horsman, D. Chaplin, K. Pinney, 2012, European journal of medicinal chemistry.