Zhengyu Yang

发表

Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.

M. Desai, G. Cheng, E. Mogalian, 2014, Journal of medicinal chemistry.

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.

T. Appleby, G. Cheng, Tetsuya Kobayashi, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HBV activity of S-substituted 7-mercapto-4-methylcoumarin analogs

Yi Xia, Jinghong Zhou, Zhengyu Yang, 2008 .

Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile

William A. Lee, M. Hatada, M. Desai, 2011 .

Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.

Yi Xia, Chin-Ho Chen, Keduo Qian, 2010, Bioorganic & medicinal chemistry.

Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.

Yi Xia, Hong-shan Liu, Chin-Ho Chen, 2011, Bioorganic & medicinal chemistry letters.

Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.

Yi Xia, Keduo Qian, K. Lee, 2010, Bioorganic & medicinal chemistry.

Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.

Q. Zhang, Yi Xia, K. Lee, 2004, Bioorganic & medicinal chemistry.

Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents.

Yi Xia, Hong-shan Liu, Keduo Qian, 2012, European journal of medicinal chemistry.

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.

William A. Lee, M. Hatada, Xiaohong Liu, 2006, Journal of molecular biology.

Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.

A. Brossi, Yi Xia, K. Lee, 2003, Bioorganic & medicinal chemistry letters.

A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano[6, 5-h]quinolin-2-oneand related compounds

A. Brossi, Yi Xia, K. Lee, 1999 .

Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa®.

G. Cheng, E. Mogalian, Jason K. Perry, 2019, Bioorganic & medicinal chemistry letters.

Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues.

Yi Xia, K. Lee, N. Kilgore, 2004, Bioorganic & medicinal chemistry letters.

In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

William A. Lee, M. Hatada, Xiaohong Liu, 2011, Antimicrobial Agents and Chemotherapy.

Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK.

Yi Xia, K. Lee, N. Kilgore, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.

Yi Xia, K. Lee, S. Morris-Natschke, 2003, Bioorganic & medicinal chemistry.

Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents.

Yi Xia, K. Lee, K. Lee, 1998, Advances in experimental medicine and biology.

Synthesis and Biological Evaluation of 6 , 7 , 2 ′ , 3 ′ , 4 ′-Substituted-1 , 2 , 3 , 4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

S. Kuo, Yi Xia, K. Lee, 1998 .

Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

Yi Xia, K. Lee, K. Bastow, 2000 .

Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.

Yi Xia, K. Lee, K. Lee, 2000, Bioorganic & medicinal chemistry letters.

Thermal Ring Closure Reaction of 4‐Methyl‐7‐(1,1‐Disubstituted Propyn‐2‐Yloxy)Chromen‐2‐Ones: The Effects of the Substituents at Propargylic Position on Reactivity and Products

Qian Zhang, Zhengyu Yang, Yifan Xia, 2004 .

Thermal Ring Closure Reaction of 4-Methyl-7-(1,1-disubstituted propyne-2-yloxy)chromen-2-ones: The Effects of the Substituents at Propargylic Position on Reactivity and Products.

Yi Xia, Qian Zhang, Zhengyu Yang, 2005 .

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

S. Kuo, M. Hour, Yi Xia, 2001, Bioorganic & medicinal chemistry letters.