Carlos A. Velázquez

发表

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs

K. Kashfi, L. Keefer, M. Chattopadhyay, 2010, Journal of Pharmacology and Experimental Therapeutics.

Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity.

E. Knaus, J. S. Mojarrad, D. Vo, 2005, Bioorganic & medicinal chemistry.

Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.

J. Reisz, Khaled R. A. Abdellatif, Jenna F Dumond, 2011, Journal of medicinal chemistry.

Nitroxide derivatives of non‐steroidal anti‐inflammatory drugs exert anti‐inflammatory and superoxide dismutase scavenging properties in A459 cells

James B. Mitchell, T. Moody, D. Wink, 2012, British journal of pharmacology.

Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

L. Keefer, M. Citro, Qiao-Hong Chen, 2008, Journal of medicinal chemistry.

Arylation of Sensitive 1-(Pyrrolidin-1-yl)-diazen-1-ium-diolate in Ionic Liquids

L. Keefer, S. Malhotra, G. Lynn, 2010 .

Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers.

E. Knaus, Carlos A. Velázquez, R. Shan, 2004, Journal of medicinal chemistry.

Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.

J. Nguyen, E. Knaus, Carlos A. Velázquez, 2005, Bioorganic & medicinal chemistry.

Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

E. Knaus, P. N. Praveen Rao, Carlos A. Velázquez, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.

E. Knaus, Carlos A. Velázquez, 2004, Bioorganic & medicinal chemistry.

Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

Syntheses, calcium channel modulation effects, and nitric oxide release studies of O2‐alkyl‐1‐(pyrrolidin‐1‐yl) diazen‐1‐ium‐1,2‐diolate 4‐aryl(heteroaryl)‐1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates

E. Knaus, D. Vo, Carlos A. Velázquez, 2003 .

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships

A. Fassihi, E. Knaus, Carlos A. Velázquez, 2004 .

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies.

J. Reisz, Khaled R. A. Abdellatif, S. King, 2010, Organic & biomolecular chemistry.

O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

L. Keefer, M. Citro, E. Knaus, 2007, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.

R. McDonald, E. Knaus, P. Rao, 2005, Bioorganic & medicinal chemistry.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2011, Bioorganic & medicinal chemistry letters.

Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation.

K. Kashfi, J. Crowell, M. Chattopadhyay, 2010, Cancer letters.

Comparison between NO-ASA and NONO-ASA as safe anti-inflammatory , analgesic , antipyretic , anti-oxidant prodrugs

K. Kashfi, L. Keefer, M. Chattopadhyay, 2010 .

Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.