R. A. Bit

发表

A convenient synthesis of bisindolyl- and indolylaryl maleic anhydrides

P. Davis, R. A. Bit, S. A. Hurst, 1990 .

Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists.

E. Demont, J. Witherington, Simon Taylor, 2015, Journal of medicinal chemistry.

Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

I. Chessell, A. Naylor, X. Lewell, 2006, Bioorganic & medicinal chemistry letters.

A Dieckmann/ring expansion approach to tetrahydropyrido- and tetrahydroazepino-[1,2-a]indoles

D. Vesey, P. Davis, C. Hill, 1991 .

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.

S. Dowell, E. Demont, J. Witherington, 2016, Journal of medicinal chemistry.

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Andrew J. Bannister, Melanie V. Leveridge, S. Robson, 2016, Journal of medicinal chemistry.

A convenient synthesis of bisindolylmaleimides

P. Crackett, C. Hill, W. Harris, 1993 .

Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose.

S. Dowell, K. Philpott, T. Heightman, 2011, Journal of medicinal chemistry.

A mild conversion of maleic anhydrides into maleimides

P. Davis, R. A. Bit, 1990 .

Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.

D. Vesey, P. Davis, P D Davis, 1993, Journal of medicinal chemistry.

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.

I. Wall, K. Philpott, T. Heightman, 2014, Journal of medicinal chemistry.

Structure-based design of peptidomimetic antagonists of p56lck SH2 domain

I. E. Smith, N. Borkakoti, D. Banner, 2002 .

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.

R. Prinjha, P. Soden, C. Chung, 2021, Journal of medicinal chemistry.

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.

S. Dowell, E. Demont, J. Witherington, 2011, ACS medicinal chemistry letters.

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Darren L. Poole, Tony W Dean, I. Wall, 2020, Journal of medicinal chemistry.

Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.

Anne Hersey, A. Hersey, G. Bravi, 2010, Bioorganic & medicinal chemistry letters.