Yosuke Demizu

发表

Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations

K. Sakai-Kato, K. Izutsu, Yuki Takechi-Haraya, 2022, AAPS PharmSciTech.

Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands.

K. Matsuno, M. Naito, Genichiro Tsuji, 2021, ACS medicinal chemistry letters.

Inhibition of β-amyloid-induced neurotoxicity by planar analogues of procyanidin B3.

M. Shibanuma, Takashi Misawa, T. Takaki, 2019, Bioorganic & medicinal chemistry letters.

Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.

Takashi Misawa, M. Kurihara, Yosuke Demizu, 2015, Bioorganic & medicinal chemistry.

Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

A. Ishii‐Watabe, Michihiko Aoyama, M. Tada, 2021, Pharmaceutical Research.

Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.

M. Naito, W. Hakamata, H. Inoue, 2018, Bioorganic & medicinal chemistry.

G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer

Yukihiro Itoh, Y. Hashimoto, M. Naito, 2017, Molecular Pharmacology.

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

M. Naito, Takashi Misawa, M. Kurihara, 2017, Bioorganic & medicinal chemistry letters.

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

M. Naito, Takashi Misawa, M. Kurihara, 2016, Bioorganic & medicinal chemistry letters.

Development of hybrid small molecules that induce degradation of estrogen receptor‐alpha and necrotic cell death in breast cancer cells

M. Naito, T. Nishimaki-Mogami, H. Okuda, 2013, Cancer science.

Development of ciclesonide analogues that block SARS-CoV-2 RNA replication

Kenzo Yonemitsu, Takahito Ito, Genichiro Tsuji, 2021, Bioorganic & Medicinal Chemistry Letters.

Protocols for Synthesis of SNIPERs and the Methods to Evaluate the Anticancer Effects.

M. Naito, Yoshinori Tsukumo, Genichiro Tsuji, 2021, Methods in molecular biology.

Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

T. Kurohara, M. Naito, N. Shibata, 2022, ChemistryOpen.

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design.

Akinori Endo, Y. Saeki, M. Naito, 2021, Journal of medicinal chemistry.

Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions

T. Kurohara, Takashi Misawa, K. Fukuhara, 2022, Processes.

Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence

Takashi Misawa, Genichiro Tsuji, M. Doi, 2018, ACS omega.

Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.

Y. Kanda, Takashi Misawa, Yosuke Demizu, 2017, Bioconjugate chemistry.

Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic α,α-disubstituted α-amino acid residues.

Y. Kikuchi, Takashi Misawa, M. Kurihara, 2017, Bioorganic & medicinal chemistry letters.

α‐Helical Structures of Oligopeptides with an Alternating l‐Leu‐Aib Segment

M. Oba, Masakazu Tanaka, Takashi Misawa, 2016 .

A Helix‐Stabilized Cell‐Penetrating Peptide as an Intracellular Delivery Tool

M. Naito, M. Oba, Masakazu Tanaka, 2016, Chembiochem : a European journal of chemical biology.

Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of l-Leu and d-Leu.

M. Oba, Masakazu Tanaka, Takashi Misawa, 2015, The Journal of organic chemistry.

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

M. Naito, M. Kurihara, N. Shibata, 2016, Methods in molecular biology.

Structure–activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine

M. Hirano, Takashi Misawa, N. Ohoka, 2021, Journal of peptide science : an official publication of the European Peptide Society.

Reaction of O6-methylguanosine with nitrite in the presence of carboxylic acid: synthesis of the purin-2-yl carboxylate

T. Maruyama, M. Ohtsuka, Yosuke Demizu, 2005 .

Conformations of peptides containing a chiral cyclic α, α‐disubstituted α‐amino acid within the sequence of Aib residues

Masakazu Tanaka, H. Okuda, M. Doi, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication

T. Fukuhara, K. Watashi, Rigel Suzuki, 2022, Journal of Pharmacological Sciences.

Analysis of the interaction of cyclosporine congeners with cell membrane models.

K. Sakai-Kato, K. Izutsu, Yuki Takechi-Haraya, 2022, Journal of pharmaceutical and biomedical analysis.

Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine.

M. Oba, Takuma Kato, Masakazu Tanaka, 2022, Bioorganic & medicinal chemistry.

Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer.

M. Naito, Takahito Ito, K. Aritake, 2020, ACS medicinal chemistry letters.

Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives

M. Baba, M. Okamoto, Takashi Misawa, 2015, Antiviral chemistry & chemotherapy.

Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling.

Chihiro Saito, R. Kawano, C. Goto, 2020, ChemPlusChem.

PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA.

Y. Imamura, K. Kuwata, M. Kurihara, 2017, Bioorganic & medicinal chemistry letters.

Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage.

Y. Imamura, K. Kuwata, M. Kurihara, 2016, Chemical & pharmaceutical bulletin.

β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone.

Y. Imamura, M. Kurihara, A. Kittaka, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator.

M. Naito, H. Inoue, Takashi Misawa, 2016, Bioorganic & medicinal chemistry.

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.

M. Makishima, M. Naito, Takashi Misawa, 2015, Bioorganic & medicinal chemistry letters.

Direct electrochemical alpha-cyanation of N-protected cyclic amines.

O. Onomura, Yosuke Demizu, S. S. Libendi, 2009, Organic & biomolecular chemistry.

Cu-Catalyzed Enantioselective Synthesis of Oxazolines from Aminotriols via Asymmetric Desymmetrization.

M. Kuriyama, O. Onomura, Kosuke Yamamoto, 2020, Chemistry, an Asian journal.

Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling.

T. Kurohara, A. Ishii‐Watabe, N. Hashii, 2022, Bioorganic & medicinal chemistry.

Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups.

M. Oba, Masakazu Tanaka, M. Doi, 2014, The Journal of organic chemistry.

Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein.

M. Naito, Yoshinori Tsukumo, Genichiro Tsuji, 2022, ACS medicinal chemistry letters.

Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

Genichiro Tsuji, N. Shibata, Miki Nakamura, 2022, International journal of molecular sciences.

The effects of magainin 2-derived and rationally designed antimicrobial peptides on Mycoplasma pneumoniae

Y. Hara-Kudo, C. Goto, Y. Kikuchi, 2022, PloS one.

Solid-Phase Nucleophilic Fluorination

W. Hakamata, H. Inoue, H. Okuda, 2012 .

Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence

Chihiro Saito, R. Kawano, C. Goto, 2021, Molecules.

Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin

M. Shibanuma, Takashi Misawa, T. Takaki, 2020, ACS omega.

Copper-Catalyzed Asymmetric Oxidative Desymmetrization of 2-Substituted 1,2,3-Triols.

M. Kuriyama, O. Onomura, Kosuke Yamamoto, 2022, The Journal of organic chemistry.

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides.

S. Gellman, M. Oba, Masakazu Tanaka, 2015, Organic & biomolecular chemistry.

Recent Advances in PROTAC Technology Toward New Therapeutic Modalities

M. Oba, Yosuke Demizu, Miyako Naganuma, 2022, Chemistry & biodiversity.

Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα.

M. Naito, N. Ohoka, K. Okuhira, 2022, Methods in molecular biology.

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.

M. Naito, C. Goto, M. Hirano, 2019, MedChemComm.

Helical structures of homo-chiral isotope-labeled α-aminoisobutyric acid peptides

Y. Izumi, M. Oba, Masakazu Tanaka, 2016 .

Organocatalytic Synthesis of Phenols from Diaryliodonium Salts with Water under Metal-Free Conditions.

M. Kuriyama, O. Onomura, Kosuke Yamamoto, 2022, Organic letters.

De Novo Design of Cell‐Penetrating Foldamers

Takashi Misawa, Y. Demizu, H. Yokoo, 2020, Chemical record.

Nonenzymatic kinetic resolution of racemic α-hydroxyalkanephosphonates with chiral copper catalyst

O. Onomura, Yosuke Demizu, A. Moriyama, 2009 .

A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products

Y. Goda, Y. Shimokawa, N. Uchiyama, 2015, Forensic Toxicology.

Design and synthesis of novel estrogen receptor antagonists with acetal containing biphenylmethane skeleton

Takashi Misawa, Takayuki Kanaya, M. Kurihara, 2021 .

Chiral Centers in the Side Chains of α‐Amino Acids Control the Helical Screw Sense of Peptides

Masakazu Tanaka, M. Doi, M. Kurihara, 2004 .

Asymmetric ring cleavage reaction with a combination of optically active cycloalkane-1,2-diol and Lewis acid: application to formal synthesis of (−)-alloyohimbane and approach to construction of adjacent chiral quaternary centers

Masakazu Tanaka, K. Sakai, Eiji Toyofuku, 2004 .

Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides

M. Kuriyama, O. Onomura, Kosuke Yamamoto, 2019, Organic Process Research & Development.

Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols

Y. Matsumura, Kazuya Matsumoto, O. Onomura, 2007 .

Helical Oligomers with a Changeable Chiral Acetal Moiety

M. Oba, Masakazu Tanaka, M. Kurihara, 2013 .

Efficient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide.

O. Onomura, Yosuke Demizu, Daishiro Minato, 2008, Angewandte Chemie.

Facile Synthesis of α‐ exo ‐Methylene Ketones from α,α‐Disubstituted Allyl Alcohols by Electrochemical Oxidative Migration

N. Kikuchi, M. Kuriyama, O. Onomura, 2019, ChemElectroChem.

An Extended Planar C5 Conformation and a 310‐Helical Structure of Peptide Foldamer Composed of Diverse α‐Ethylated α,α‐Disubstituted α‐Amino Acids

M. Oba, Masakazu Tanaka, M. Kurihara, 2003 .

Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides

Takashi Misawa, H. Yamashita, M. Kurihara, 2015 .

Regioselective protection of sugars catalyzed by dimethyltin dichloride.

Y. Matsumura, T. Maki, O. Onomura, 2008, Organic letters.

Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with a chiral Cu(II) complex

Y. Matsumura, Kazuya Matsumoto, O. Onomura, 2006 .

Diastereoselective arylation of l-proline derivatives at the 5-position

Y. Matsumura, O. Onomura, P. Kirira, 2008 .

Side-chain chiral centers of amino acid and helical-screw handedness of its peptides.

Masakazu Tanaka, M. Doi, M. Kurihara, 2005, Journal of the American Chemical Society.

Convenient synthesis of an enantiomerically pure bicyclic proline and its N-oxyl derivatives

Kazuya Matsumoto, O. Onomura, Hirofumi Shiigi, 2008 .

Facile synthesis of optically active oxindoles by copper-catalyzed asymmetric monotosylation of prochiral 1,3-diols

M. Kuriyama, O. Onomura, Yosuke Demizu, 2010 .

Asymmetric oxidation of 1,2-diols using N-bromosuccinimide in the presence of chiral copper catalyst

Y. Matsumura, O. Onomura, Yosuke Demizu, 2007 .

Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium

T. Maruyama, Y. Goda, M. Kurihara, 2014, Journal of Natural Medicines.

Monoallylation of 1,2-diols by Pd/Sn bimetallic catalysis.

Masaaki Ito, M. Kuriyama, O. Onomura, 2012, Chemistry.

Development of small molecule chimeras that recruit AhR E3 ligase to target proteins.

M. Naito, Y. Demizu, Genichiro Tsuji, 2019, ACS chemical biology.

Diastereomeric Right- and Left-Handed Helical Structures with Fourteen (R)-Chiral Centers.

M. Oba, Masakazu Tanaka, Takashi Tanaka, 2017, Chemistry.

Conformational studies on peptides containing α,α-disubstituted α-amino acids: chiral cyclic α,α-disubstituted α-amino acid as an α-helical inducer.

Masakazu Tanaka, H. Okuda, M. Doi, 2011, Organic & biomolecular chemistry.

Controlling 310-Helix and α-Helix of Short Peptides in the Solid State

Masakazu Tanaka, M. Doi, M. Kurihara, 2007 .

Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols

Tomoaki Tanaka, O. Onomura, Hirofumi Shiigi, 2008 .

Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols, and aminoaldehydes in the presence of chiral copper catalyst

O. Onomura, Yosuke Demizu, Daishiro Minato, 2008 .

Regioselective Introduction of Electrophiles into Piperidine Derivatives at the 4-Position

Y. Matsumura, O. Onomura, Yosuke Demizu, 2008 .

Helical l–Leu-Based Peptides Having Chiral Five-Membered Carbocyclic Ring Amino Acids with an Ethylene Acetal Moiety

M. Oba, Masakazu Tanaka, M. Doi, 2017 .

Synthesis of chiral five‐membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo‐chiral homopeptides

M. Oba, Masakazu Tanaka, M. Doi, 2016, Biopolymers.

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids.

Masaaki Kurihara, Takashi Misawa, M. Oba, 2016, Bioorganic & medicinal chemistry.

One-handed helical screw direction of homopeptide foldamer exclusively induced by cyclic α-amino acid side-chain chiral centers.

Masakazu Tanaka, M. Doi, M. Kurihara, 2012, Chemistry.

Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers.

Masakazu Tanaka, M. Doi, M. Kurihara, 2009, Organic letters.

Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids

M. Hirano, Takashi Misawa, Yosuke Demizu, 2021, ChemMedChem.

Helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid.

M. Doi, M. Kurihara, Yukiko Sato, 2013, The Journal of organic chemistry.

Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H···Ethereal O-Type Hydrogen Bond.

M. Oba, Takuma Kato, Masakazu Tanaka, 2018, Organic letters.

Peptide foldamers composed of six-membered ring α,α-disubstituted α-amino acids with two changeable chiral acetal moieties

Kazuya Kato, M. Oba, Masakazu Tanaka, 2015 .

Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.

M. Oba, Masakazu Tanaka, H. Yamashita, 2014, Bioorganic & medicinal chemistry.

Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical l-Leu-based peptides

Masakazu Tanaka, K. Nagasawa, H. Okuda, 2011 .

Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of ( E )-chalcone

Masakazu Tanaka, K. Nagasawa, H. Okuda, 2011 .

Amino equatorial effect of a six-membered ring amino acid on its peptide 3 10 - and α-helices

M. Oba, Masakazu Tanaka, M. Doi, 2015 .

Conformations of helical Aib peptides containing a pair of l‐amino acid and d‐amino acid

Masakazu Tanaka, M. Doi, M. Kurihara, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Effect of one D‐Leu residue on right‐handed helical ‐L‐Leu‐Aib‐ peptides in the crystal state

Masakazu Tanaka, H. Okuda, M. Doi, 2011, Journal of peptide science : an official publication of the European Peptide Society.

Solid-state conformation of diastereomeric -Pro-Pro-(Aib)4 sequences

M. Oba, Masakazu Tanaka, H. Okuda, 2010 .

Controlling the helical screw sense of peptides with C‐terminal L‐valine

Masakazu Tanaka, H. Okuda, M. Doi, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Low pH-triggering changes in peptide secondary structures.

M. Oba, K. Furukawa, Masakazu Tanaka, 2017, Organic & biomolecular chemistry.

Synthesis of Chiral α‐Trifluoromethyl α,α‐Disubstituted α‐Amino Acids and Conformational Analysis of L‐Leu‐Based Peptides with ( R )‐ or ( S )‐α‐Trifluoromethylalanine

M. Oba, Masakazu Tanaka, M. Doi, 2020 .

Influence of L-Leu to D-Leu Replacement on the Helical Secondary Structures of L-Leu-Aib-Based Dodecapeptides

M. Oba, Masakazu Tanaka, Takashi Misawa, 2016 .

Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues

M. Oba, Masakazu Tanaka, M. Doi, 2014 .

Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense.

Masakazu Tanaka, M. Doi, H. Yamashita, 2013, The Journal of organic chemistry.

Screw-sense control of helical oligopeptides containing equal amounts of L- and D-amino acids.

Masakazu Tanaka, H. Okuda, M. Doi, 2011, Chemistry.

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.

M. Naito, M. Oba, Masakazu Tanaka, 2017, Bioorganic & Medicinal Chemistry.

Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.

M. Doi, M. Kurihara, Yukiko Sato, 2013, Bioorganic & medicinal chemistry letters.

Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments.

Masakazu Tanaka, M. Doi, M. Kurihara, 2012, The Journal of organic chemistry.

Three-dimensional structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state.

Masakazu Tanaka, H. Okuda, M. Doi, 2010, The Journal of organic chemistry.

The side‐chain hydroxy groups of a cyclic α,α‐disubstituted α‐amino acid promote oligopeptide 310‐helix packing in the crystalline state

M. Oba, Masakazu Tanaka, Takashi Misawa, 2016, Biopolymers.

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

Y. Sekino, M. Naito, Y. Kanda, 2015, Bioorganic & medicinal chemistry.

Handedness Preferences of Heterochiral Helical Peptides Containing Homochiral Peptide Segments

M. Oba, Masakazu Tanaka, Takashi Misawa, 2016 .

Helical structures of bicyclic α-amino acid homochiral oligomers with the stereogenic centers at the side-chain fused-ring junctions

M. Oba, Masakazu Tanaka, M. Doi, 2012 .

Preorganized Cyclic α,α-Disubstituted α-Amino Acids Bearing Functionalized Side Chains That Act as Peptide-Helix Inducers.

K. Matsuno, Takashi Misawa, Y. Demizu, 2017, The Journal of organic chemistry.

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment

M. Naito, M. Oba, Takuma Kato, 2016, Scientific Reports.

Methyl 2-[(2-{2-[(2-acetamidophenyl)ethynyl]benzamido} phenyl)ethynyl]benzoate

Takashi Misawa, M. Doi, M. Kurihara, 2015 .

Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides.

Masakazu Tanaka, Takashi Misawa, M. Doi, 2015, Chemical & pharmaceutical bulletin.

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

Y. Sekino, M. Naito, Y. Kanda, 2014, Bioconjugate chemistry.

1,4-Bis[(N-acetyl-l-phenylalanyl-glycyl-l-alanyl)aminomethyl]benzene

Takashi Misawa, M. Kurihara, Yosuke Demizu, 2016 .

Oligoarginine-Conjugated Peptide Foldamers Inhibiting Vitamin D Receptor-Mediated Transcription

T. Kurohara, Keiko Yamamoto, Y. Kanda, 2022, ACS omega.

Structure–Activity Relationship Studies of Substitutions of Cationic Amino Acid Residues on Antimicrobial Peptides

N. Matsunaga, Takashi Misawa, M. Takada, 2022, Antibiotics.

Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls

Y. Matsumura, O. Onomura, Hirofumi Shiigi, 2008 .

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells

Y. Sekino, Y. Kotake, Y. Kanda, 2014, Scientific Reports.

Ring contraction of α,β-unsaturated cyclic amines with cis-dihydroxylation at the α,β-position

Y. Matsumura, O. Onomura, Yosuke Demizu, 2009 .

Synthesis of 6-Arylthio Analogs of 2′,3′-Dideoxy-3′-Fluoroguanosine and Their Effect against Hepatitis B Virus Replication

E. De Clercq, J. Neyts, T. Maruyama, 2006, Nucleosides, nucleotides & nucleic acids.

Comprehensive Synthesis of 20 Fentanyl Derivatives for Their Rapid Differentiation by GC-MS Analysis

T. Kurohara, Takashi Misawa, Genichiro Tsuji, 2023, HETEROCYCLES.

Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents.

M. Baba, M. Kurihara, T. Maruyama, 2013, Bioorganic & medicinal chemistry.

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives

G. Balboni, M. Baba, M. Okamoto, 2015, Antiviral chemistry & chemotherapy.

High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

Y. Matsumura, O. Onomura, Yosuke Demizu, 2008 .

High Regioselectivity in Electrochemical α‐Methoxylation of N‐Protected Cyclic Amines.

Y. Matsumura, O. Onomura, Yosuke Demizu, 2008 .

Electrochemical Oxidation of L-Prolinol Derivative Protected with 1-Alkoxy-2,2,2-trifluoroethyl Group

Y. Matsumura, T. Maki, O. Onomura, 2006 .

Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation

T. Kurohara, M. Naito, Y. Demizu, 2021, International journal of molecular sciences.

Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.

M. Naito, N. Ohoka, Yosuke Demizu, 2020, Bioorganic & medicinal chemistry.

Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

M. Naito, M. Ishikawa, Shusuke Tomoshige, 2020, Pharmaceuticals.

Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products

H. Akiyama, Yasuhiro Abe, Y. Goda, 2019, Scientific Reports.

Current Status of Oligonucleotide-Based Protein Degraders

M. Naito, Po-Chang Shih, Yosuke Demizu, 2023, Pharmaceutics.

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

T. Akiyama, K. Ui-Tei, M. Naito, 2020, Oncogene.

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery.

M. Naito, M. Oba, Masakazu Tanaka, 2019, Chemical communications.

Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor.

T. Kurohara, H. Akiyama, Takashi Misawa, 2021, Bioorganic & Medicinal Chemistry.

N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride.

Y. Goda, N. Uchiyama, Sayaka Masada, 2021, Chemical & pharmaceutical bulletin.

Temperature-dependent formation of N-nitrosodimethylamine during the storage of ranitidine reagent powders and tablets.

Yasuhiro Abe, Y. Goda, N. Uchiyama, 2020, Chemical & pharmaceutical bulletin.

Facile synthesis of kwakhurin, a marker compound of Pueraria mirifica and its quantitative NMR analysis for standardization as a reagent.

N. Uchiyama, Sayaka Masada, T. Hakamatsuka, 2020, Chemical & pharmaceutical bulletin.

Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton

M. Makishima, Takashi Misawa, Y. Demizu, 2020, ChemMedChem.

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.

M. Naito, Takashi Misawa, Y. Demizu, 2017, Journal of Medicinal Chemistry.

Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst

O. Onomura, M. Mitsuda, Yosuke Demizu, 2007 .

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

M. Naito, H. Okuda, M. Kurihara, 2012, Bioorganic & medicinal chemistry letters.

Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus.

Y. Demizu, Genichiro Tsuji, Takuji Shoda, 2021, Bioorganic & medicinal chemistry letters.

Analysis of an Impurity, N-Nitrosodimethylamine, in Valsartan Drug Substances and Associated Products Using GC-MS.

H. Akiyama, Yasuhiro Abe, Y. Goda, 2019, Biological & pharmaceutical bulletin.

Developmental Trends of Peptide Drugs and Their Quality Assessment using Secondary Structure Analysis

Takashi Misawa, Yosuke Demizu, 2023, ChemistrySelect.

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

Akinori Endo, K. Igarashi, Y. Saeki, 2021, Molecular cell.

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

S. Yagi, Guoying Wu, J. Penninger, 2016, The Journal of experimental medicine.

Synthesis and Resolution of Substituted [5]Carbohelicenes.

M. Kurihara, Kazuteru Usui, H. Suemune, 2015, The Journal of organic chemistry.

Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents.

Takashi Misawa, M. Kurihara, I. Tsukamoto, 2015, Chemical & pharmaceutical bulletin.

Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

Keiji Tanaka, M. Naito, Koji Yamano, 2020, The Journal of cell biology.

Development of Agonist-Based PROTACs Targeting Liver X Receptor

T. Ohtsuki, M. Naito, Kanako Nemoto, 2021, Frontiers in Chemistry.

Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity.

Keisuke Tsuchiya, Yosuke Demizu, Hiroyuki Takada, 2022, Bioconjugate chemistry.

Development of a peptide-based inducer of protein degradation targeting NOTCH1.

M. Naito, Takashi Misawa, M. Kurihara, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine.

M. Kurihara, S. Moriya, A. Kittaka, 2023, Bioorganic & medicinal chemistry letters.

Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence

K. Hayashi, Y. Hara-Kudo, C. Goto, 2019, ChemMedChem.

Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.

M. Naito, H. Inoue, M. Kurihara, 2014, Bioorganic & medicinal chemistry letters.

Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor.

M. Naito, Genichiro Tsuji, N. Ohoka, 2023, ACS medicinal chemistry letters.

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.

M. Oba, Masakazu Tanaka, M. Kurihara, 2015, Bioorganic & medicinal chemistry.

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton.

M. Makishima, Y. Sekino, M. Naito, 2017, MedChemComm.

Development of a peptide-based inducer of nuclear receptors degradation.

M. Naito, Takashi Misawa, M. Kurihara, 2016, Bioorganic & medicinal chemistry letters.

Amine skeleton-based c-di-GMP derivatives as biofilm formation inhibitors.

K. Hayashi, Y. Hara-Kudo, Y. Demizu, 2020, Bioorganic & medicinal chemistry letters.

Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

M. Naito, H. Inoue, Y. Demizu, 2020, Pharmaceuticals.

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.

M. Takimoto-Kamimura, Y. Demizu, H. Okuda, 2011, Bioorganic & medicinal chemistry letters.

Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis.

Y. Goda, H. Okuda, M. Kurihara, 2011, Chemical & pharmaceutical bulletin.

Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic.

Katsuya Tanaka, Takashi Misawa, M. Kurihara, 2017, Bioorganic & medicinal chemistry letters.

Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives.

K. Matsuno, M. Oba, Masakazu Tanaka, 2018, Chemical & pharmaceutical bulletin.

Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro

Takashi Misawa, Kosuke Saito, Yosuke Demizu, 2023, Biomolecules.

Magainin 2-derived stapled peptides derived with the ability to deliver pDNA, mRNA, and siRNA into cells

C. Goto, Takashi Misawa, Yosuke Demizu, 2023, Chemical science.

Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands.

M. Naito, Genichiro Tsuji, N. Ohoka, 2023, Bioorganic & medicinal chemistry.

Structure-Activity Relationship Study of Helix-Stabilized Antimicrobial Peptides Containing Nonproteinogenic Amino Acids.

R. Kawano, Takashi Misawa, N. Ohoka, 2023, ACS biomaterials science & engineering.

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.

M. Naito, C. Goto, Y. Kikuchi, 2019, MedChemComm.

(3+2) Cycloaddition of Heteroaromatic N-Ylides with Sulfenes.

M. Kuriyama, O. Onomura, Yosuke Demizu, 2024, Organic letters.

Brain Wave (EEG) AI Analysis for the DX Era

A. Konagaya, E. Yonemochi, Kazuma Kaitoh, 2022 .

Development of STING degrader with double covalent ligands.

Genichiro Tsuji, N. Shibata, Yosuke Demizu, 2024, Bioorganic & medicinal chemistry letters.

Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives.

K. Matsuno, M. Oba, Masakazu Tanaka, 2018, Chemical & pharmaceutical bulletin.

Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells.

Takashi Misawa, M. Kurihara, Takuji Shoda, 2017, Bioorganic & medicinal chemistry letters.

Dual-modified penetratin peptides: Enhancing nucleic acid delivery through stapling and endosomal escape domain.

Keisuke Tsuchiya, Yosuke Demizu, Hidetomo Yokoo, 2024, Bioorganic & medicinal chemistry.

Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery

Yosuke Demizu, Hidetomo Yokoo, Maho Miyamoto, 2024, Expert opinion on drug discovery.