R. Lehr

发表

Synthesis of enantiomerically pure bay-region 3,4-diol 1,2-epoxide diastereomers and other derivatives of the potent carcinogen dibenz [c,h] acridine

D. Jerina, N. Shirai, Subodh Kumar, 1985 .

Bacterial and mammalian cell mutagenicity of four optically active bay-region 3,4-diol-1,2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine.

D. Jerina, A. Conney, W. Levin, 1986, Cancer research.

Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice.

D. Jerina, A. Conney, R. Chang, 2000, Carcinogenesis.

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.

D. Jerina, A. Conney, D. Thakker, 1978, Cancer research.

Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid.

D. Jerina, M. Huang, A. Conney, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Tumorigenicity of bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene on mouse skin and in newborn mice.

D. Jerina, A. Conney, W. Levin, 1982, Cancer research.

Operational Criteria for Evaluation of Concertedness in Potential Pericyclic Reactions

A. P. Marchand, R. Lehr, 1977 .

Mutagenicity of the bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene.

D. Jerina, A. Conney, P. Thomas, 1981, Cancer research.

Acetoxylation at benzylic positions of tetrahydrobenzo rings with DDQ in acetic acid

P. Kole, K. Tschappat, R. Lehr, 1986 .

Reduction of tumorigenicity and of dihydrodiol formation by fluorine substitution in the angular rings of dibenzo(a,i)pyrene.

E. LaVoie, S. Hecht, E. Boger, 1981, Cancer research.

Tumorigenicity of the diastereomeric bay-region benzo(e)pyrene 9,10-diol-11,12-epoxides in newborn mice.

D. Jerina, A. Conney, W. Levin, 1981, Cancer research.

Metabolism of benzo(e)pyrene by rat liver microsomal enzymes.

D. Jerina, J. Selkirk, M. Macleod, 1980, Carcinogenesis.

Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice.

D. Jerina, C. Taylor, A. Conney, 1980, Cancer research.

Appendix I – Update to Vol. IIA: Polycyclic Aromatic Hydrocarbons and Carcinogenesis: The Bay-Region Theory

D. Jerina, A. Conney, D. Thakker, 1982 .

Dihydrodiols and diol epoxides of dibenzo[a,i]-and [a,h]pyrene

D. Jerina, Subodh Kumar, R. Lehr, 1979 .

8 – The Bay-Region Theory of Carcinogenesis by Polycyclic Aromatic Hydrocarbons

M. Schaefer-Ridder, D. Jerina, J. Karle, 1978 .

Synthesis and reactivity of diol epoxides derived from non-K-region trans-dihydrodiols of benzo[a]anthracene

M. Schaefer-Ridder, D. Jerina, R. Lehr, 1977 .

THE BAY-REGION THEORY: A QUANTUM MECHANICAL APPROACH TO AROMATIC HYDROCARBON-INDUCED CARCINOGENICITY

D. Jerina, Donald M. Jerina, R. E. Lehr, 1977 .

The Bay Region Theory of Polycyclic Aromatic Hydrocarbon Carcinogenesis

D. Jerina, A. Conney, W. Levin, 1985 .

Regioselective ring opening of polycyclic aromatic hydrocarbon epoxides by polymer-supported azide anion

M. Lakshman, D. Nadkarni, R. Lehr, 1990 .

Chlorpromazine metabolism IV: quaternization as a key to determination of picomoles of chlorpromazine and other tertiary amine drugs.

P. N. Kaul, R. Lehr, 1975, Journal of pharmaceutical sciences.

Thermolyses of tert-butyl .DELTA.1,1'-dicyclohexenylperoxyacetate. Electrocyclic and other transformations of a pentadienyl radical

J. Harder, J. Wilson, R. Lehr, 1976 .

ANSWERS TO PROBLEMS IN CHAPTER II

A. P. Marchand, R. Lehr, 1972 .

THERMOLYSES OF TERT-BUTYL Δ1,1′-DICYCLOHEXENYLPEROXYACETATE. ELECTROCYCLIC AND OTHER TRANSFORMATIONS OF A PENTADIENYL RADICAL

J. Harder, J. Wilson, R. Lehr, 1976 .

Synthesis of polycyclic aromatic hydrocarbon 2′-deoxyadenosine analogs

M. Lakshman, R. Lehr, 1990 .

Tumorigenicity of the diastereomeric benz[a]anthracene 3,4-diol-1,2-epoxides and the (+)- and (-)-enantiomers of benz[a]anthracene 3,4-dihydrodiol in newborn mice.

D. Jerina, A. Conney, D. Thakker, 1979, Journal of the National Cancer Institute.

6-Hydroxydopamine and Related Catecholaminergic Neurotoxins

Russell J. Lewis, C. Blank, R. Lehr, 1998 .

Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.

M. Schaefer-Ridder, D. Jerina, J. Karle, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Mutagenicity of diol-epoxides and tetrahydroepoxides of benz(a)acridine and benz(c)acridine in bacteria and in mammalian cells.

M. Schaefer-Ridder, D. Jerina, A. Conney, 1983, Cancer research.

Biological activity of benzo[e]pyrene. An assessment based on mutagenic activities and metabolic profiles of the polycyclic hydrocarbon and its derivatives.

N. Whittaker, D. Jerina, Subodh Kumar, 1979, The Journal of biological chemistry.

Tumor-initiating activity of benz[c]acridine and twelve of its derivatives on mouse skin.

D. Jerina, A. Conney, W. Levin, 1983, Cancer research.

Exceptional carcinogenic activity of benz[a]anthracene 3,4-dihydrodiol in the newborn mouse and the bay region theory.

M. Schaefer-Ridder, D. Jerina, J. Karle, 1978, Cancer research.

Mutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxides.

M. Schaefer-Ridder, D. Jerina, J. Karle, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and properties of the vicinal trans dihydrodiols of anthracene, phenanthrene, and benzo[a]anthracene

M. Schaefer-Ridder, D. Jerina, R. Lehr, 1977 .

Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: evidence for bay region activation of carcinogenic polycyclic hydrocarbons.

A. Y. Lu, M. Schaefer-Ridder, D. Jerina, 1976, Biochemical and biophysical research communications.

Metabolic activations of polycyclic hydrocarbons

D. Jerina, R. Lehr, 1977, Archives of Toxicology.

Relationships of quantum mechanical calculations, relative mutagenicity of benzo[a]anthracene diol epoxides, and "bay region" concept of aromatic hydrocarbon carcinogenicity.

D. Jerina, R. Lehr, 1977, Journal of toxicology and environmental health.

Solvent Dependent Changes in the Proton NMR Spectra of 2′-Deoxyadenosine and Its Derivatives

M. Lakshman, R. Lehr, 1992 .

Synthesis of 1,2-Epoxy-1,2,3,4-Tetrahydrobenzo[g]chrysene: The First Synthesis of a FJORD-Region Tetrahydroepoxide

M. Lakshman, R. Lehr, 1994 .

Structure-reactivity indices for the hydrolysis of diol epoxides of polycyclic aromatic hydrocarbons

D. Jerina, J. M. Sayer, H. Yagi, 1982 .

Synthesis of optically active Fjord-region 11,12-diol 13,14-epoxides and the K-region 9,10-oxide of the carcinogen benzo(g)chrysene

D. Jerina, S. Grossman, D. R. Bushman, 1989 .

Mutagenicity and tumor-initiating activity of cyclopenta(c,d)pyrene and structurally related compounds.

D. Jerina, A. Conney, P. Thomas, 1980, Cancer research.

Aza-polycyclic aromatic hydrocarbon carcinogenicity: predictions of reactivity of tetrahydrobenzo ring epoxide derivatives

D. Jerina, R. Lehr, 1983 .

Chapter VII – SYNTHESIS AND STRUCTURAL ANALYSIS

A. P. Marchand, R. Lehr, 1972 .

Fjord region 3,4-diol 1,2-epoxides and other derivatives in the 1,2,3,4- and 5,6,7,8-benzo rings of the carcinogen benzo[g]chrysene

R. Lehr, Mahatam Singh, C. M. Utermoehlen, 1987 .

Synthesis of the angular ring tetrahydroepoxides of the carcinogens 7- and 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene

P. Kole, K. Tschappat, R. Lehr, 1989 .

α-methyl-6-aminodopamine: Depletion of catecholamines in mouse brain and peripheral tissues

R. Kostrzewa, C. L. Blank, R. Lehr, 1980 .

Reductionof Tumorigenicityand of DihydrodiolFormation by Fluorine Substitutionin the Angular Ringsof Dibenzo(a,/)pyrene1

E. LaVoie, S. Hecht, E. Boger, 1981 .

BAY-REGION ACTIVATION OF POLYCYCLIC AROMATIC HYDROCARBONS TO ULTIMATE MUTAGENS AND CARCINOGENS

D. Jerina, A. Conney, D. Thakker, 1980 .

Metabolism of trans-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide.

A. Y. Lu, D. Jerina, A. Conney, 1978, Molecular pharmacology.

Synthesis of dihydrodiol and other derivatives of benz[c]acridine

Subodh Kumar, R. Lehr, 1981 .

Benzo-ring diol epoxides of benzo[e]pyrene and triphenylene

D. Jerina, D. Thakker, H. Yagi, 1979 .

Mutagenicityof Benzo(e)pyreneandTriphenyleneTetrahydroepoxides and Diol-Epoxides in Bacterialand MammalianCells

Subodh Kumar, R. Chang, A. Wood, 1985 .

BENZO-RING DIOL EPOXIDES OF BENZO(E)PYRENE AND TRIPHENYLENE

D. Jerina, D. Thakker, H. Yagi, 1980 .

Synthesis of the non-K-region and K-region trans-dihydrodiols of benzo[e]pyrene

D. Jerina, Subodh Kumar, R. Lehr, 1978 .

Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.

D. Jerina, A. Conney, D. Thakker, 1981, Cancer research.

Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells.

D. Jerina, Subodh Kumar, A. Conney, 1980, Cancer research.

Metabolism of benzo[a]anthracene to its tumorigenic 3,4-dihydrodiol.

D. Jerina, J. Karle, A. Conney, 1979, Molecular pharmacology.

The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats.

D. Jerina, A. Chadha, J. Adams, 1999, Chemico-biological interactions.

Tumorigenicity of dihydrodiols and diol-epoxides of benz[c]acridine in newborn mice.

D. Jerina, A. Conney, W. Levin, 1984, Cancer research.

Comparative solvolytic reactivity of bay-region diol epoxides derived from dibenz[a,j]anthracene and dibenzacridines

D. Jerina, H. Yeh, G. Holder, 1990 .

Comparative Solvolytic Reactivity of Bay-Region Diol Epoxides Derived from Dibenz(a,j)anthracene and Dibenzacridines

D. Jerina, H. Yeh, G. Holder, 1990 .

Tumorigenicityof Dihydrodiolsand Diol-Epoxidesof Benz(c)acridinein NewbornMice

D. Jerina, A. Conney, W. Levin, 1984 .