N. Kallan

发表

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Jun Liang, J. Blake, B. Brandhuber, 2012, Journal of medicinal chemistry.

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

Xingrong Liu, J. Lyssikatos, C. Hop, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate

S. Shakya, Peter J. Stengel, N. Kallan, 2014 .

A potential therapeutic target for FLT3-ITD AML: PIM1 kinase.

J. E. Robinson, S. Gross, M. Levis, 2012, Leukemia research.

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.

Tyler T. Risom, J. Blake, B. Brandhuber, 2010, Bioorganic & medicinal chemistry letters.

Discovery and SAR of spirochromane Akt inhibitors.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of the ring system of phomactin D using a Suzuki macrocyclization.

R. Halcomb, N. Kallan, 2000, Organic letters.

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Tyler T. Risom, S. Gross, J. Blake, 2011, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.

J. E. Robinson, J. Lyssikatos, R. K. DeLisle, 2014, ACS medicinal chemistry letters.

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.

G. Vigers, Xingrong Liu, Darin J. Smith, 2013, Journal of medicinal chemistry.

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

Xingrong Liu, J. Lyssikatos, C. Hop, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats

Xingrong Liu, C. Hop, Shuguang Ma, 2014, Drug Metabolism and Disposition.

Discovery of pyrrolopyrimidine inhibitors of Akt.

Tyler T. Risom, S. Gross, J. Blake, 2010, Bioorganic & medicinal chemistry letters.

Microsoft Word-93038660-file00

C. Hop, S. C. Khojasteh, A. Deese, 2014 .

PIM: An Integral Component of FLT3 Signaling and a Potential Therapeutic Target in Acute Myeloid Leukemia.

S. Gross, M. Levis, D. Small, 2009 .