Sivakumar Viswanathan

发表

S. Cook, S. Chothani, S. Schafer, 2020, Scientific Reports.

IL-11 is a therapeutic target in idiopathic pulmonary fibrosis

S. Cook, A. Chacko, S. Chothani, 2018, bioRxiv.

A high-resolution map of human RNA translation.

John F. Ouyang, O. Rackham, N. Whiffin, 2022, Molecular cell.

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

S. Chothani, S. Cook, A. Widjaja, 2022, bioRxiv.

Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action for nintedanib

S. Cook, D. Carling, B. Singh, 2021, bioRxiv.

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

D. Carling, B. Singh, S. Schafer, 2021, Frontiers in Molecular Biosciences.

Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome

S. Schafer, S. Cook, Benjamin Ng, 2022, Circulation research.

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

S. Cook, S. Albani, S. Chothani, 2019, Gastroenterology.

IL-11 neutralising therapies target hepatic stellate cell-induced liver inflammation and fibrosis in NASH

S. Cook, S. Albani, S. Chothani, 2018, bioRxiv.

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

S. Cook, S. Albani, S. Chothani, 2019, bioRxiv.

Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis

S. Cook, S. Chothani, B. Singh, 2020, bioRxiv.

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

S. Cook, J. Dear, S. Chothani, 2019, bioRxiv.

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts

S. Cook, S. Albani, S. Chothani, 2021, Rheumatology.

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling underlies TGFβ-mediated activation of dermal fibroblasts Running head: IL11 in dermal fibrosis

S. Albani, S. Chothani, S. Schafer, 2021 .

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

E. Petretto, N. Hübner, S. Chothani, 2022, Nature Communications.

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome

P. Tan, N. Hübner, T. Coffman, 2022, Journal of the American Society of Nephrology : JASN.

The Translational Landscape of the Human Heart

Catherine L. Worth, S. V. Heesch, J. Seidman, 2019, Cell.

IL-11 is a crucial determinant of cardiovascular fibrosis

S. V. Heesch, J. Seidman, E. Petretto, 2017, Nature.

Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease

S. Albani, S. Chothani, S. Schafer, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

J. Dear, S. Chothani, B. Singh, 2021, Science Translational Medicine.

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

E. Petretto, S. Cook, C. Pua, 2022, bioRxiv.

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

S. Schafer, S. Cook, Benjamin Ng, 2022, International journal of molecular sciences.

Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload

S. Cook, L. Ye, S. Schafer, 2021, Clinical and experimental pharmacology & physiology.

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

S. Cook, S. Schafer, B. Corden, 2020, Scientific Reports.

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

S. Cook, A. Chacko, S. Chothani, 2019, Science Translational Medicine.

deltaTE: Detection of Translationally Regulated Genes by Integrative Analysis of Ribo‐seq and RNA‐seq Data

John F Ouyang, Owen J L Rackham, Sivakumar Viswanathan, 2019, Current protocols in molecular biology.

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

D. Carling, S. Cook, A. Widjaja, 2022, iScience.

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR in hepatocytes, the stroma and cancer cells

D. Carling, S. Cook, A. Widjaja, 2022, bioRxiv.

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

S. Cook, S. Schafer, A. Widjaja, 2021, eLife.

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

S. Cook, S. Chothani, B. Singh, 2021, Nature Communications.

Critical Conditions for Studying Interleukin‐11 Signaling In Vitro and Avoiding Experimental Artefacts

S. Schafer, S. Cook, C. Pua, 2021, Current Protocols.

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

Eleni G. Christodoulou, Stuart A. Cook, Sivakumar Viswanathan, 2019, Circulation.

Hypoxia-Induced Cellular and Vascular Changes in the Nucleus Tractus Solitarius and Ventrolateral Medulla

E. Ling, C. Kaur, S. Viswanathan, 2011, Journal of neuropathology and experimental neurology.