D. Shore

发表

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2013, ACS medicinal chemistry letters.

Mild and general conditions for the cross-coupling of aryl halides with pentafluorobenzene and other perfluoroaromatics.

K. Fagnou, M. Lafrance, D. Shore, 2006, Organic letters.

Mild and general conditions for the cross-coupling of aryl halides with pentafluorobenzene and other perfluoroaromatics.

K. Fagnou, M. Lafrance, D. Shore, 2006, Organic letters.

Decarboxylative ketone aldol reactions: development and mechanistic evaluation under metal-free conditions.

Sophie A. L. Rousseaux, N. Blaquière, K. Fagnou, 2009, The Journal of organic chemistry.

Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids

J. Lyssikatos, Anthony A. Estrada, D. Shore, 2015 .

Mild and General One-Pot Reductionand Cyclization of Aromatic and Heteroaromatic 2-Nitroaminesto Bicyclic 2H-Imidazoles

J. Lyssikatos, B. Chan, Anthony A. Estrada, 2010 .

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

A. Beresford, A. Medhurst, Xingrong Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

Jason Drummond, Xingrong Liu, Yichin Liu, 2012, Journal of medicinal chemistry.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

M. Volgraf, A. Rohou, Jun Chen, 2021, Journal of medicinal chemistry.

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

S. Sideris, L. Friedman, S. Malek, 2013, Journal of medicinal chemistry.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Simon S. Gao, J. Elstrott, M. Volgraf, 2021, The Journal of experimental medicine.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.

Jun Chen, D. Hackos, J. Lyssikatos, 2016, Bioorganic & medicinal chemistry letters.