C. Lubrano-berthelier

发表

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response.

K. Clément, A. Basdevant, P. Plas, 2010, The Journal of endocrinology.

The human MC4R promoter: characterization and role in obesity.

C. Vaisse, K. Haas, Martha Cavazos, 2003, Diabetes.

Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

K. Clément, C. Vaisse, P. Tounian, 2008, Pediatric Research.

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function

Supriya Srinivasan, C. Vaisse, C. Govaerts, 2005, Peptides.

[Genetics of human obesity].

K. Clément, C. Lubrano-berthelier, 2006, La Revue de medecine interne.

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.

B. Conklin, C. Vaisse, C. Govaerts, 2004, The Journal of clinical investigation.

Molecular Genetics of Human Obesity‐Associated MC4R Mutations

K. Clément, P. Froguel, C. Vaisse, 2003, Annals of the New York Academy of Sciences.

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.

Philippe Froguel, P. Froguel, E. Durand, 2003, Human molecular genetics.

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.

K. Clément, S. Bertrais, S. Hercberg, 2006, The Journal of clinical endocrinology and metabolism.

Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency.

K. Clément, G. Karsenty, J. Ahn, 2006, Endocrinology.

A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

Pierre Bougnères, C. Vaisse, P. Bougnères, 2004, The Journal of clinical endocrinology and metabolism.

Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion.

E. Bertin, J. Mourot, B. Portha, 2008, American journal of physiology. Endocrinology and metabolism.