L. Schenkel

发表

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.

Dong Liu, R. Fremeau, H. Bregman, 2016, Journal of medicinal chemistry.

Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.

P. Gallant, T. Bush, M. Morrison, 2010, Journal of medicinal chemistry.

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.

Stephanie D. Geuns-Meyer, N. Gavva, Y. Teffera, 2016, Journal of medicinal chemistry.

Selective pharmaceutical inhibition of PARP14 mitigates allergen-induced IgE and mucus overproduction in a mouse model of pulmonary allergic response

Kevin C. Chen, M. Niepel, K. Swinger, 2021, bioRxiv.

Self-condensation of N-tert-butanesulfinyl aldimines: application to the rapid asymmetric synthesis of biologically important amine-containing compounds.

J. Ellman, L. Schenkel, 2004, Organic letters.

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.

T. Bush, A. Cheng, D. Whittington, 2011, Bioorganic & medicinal chemistry letters.

Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule

Tim J. Wigle, M. Niepel, K. Swinger, 2021, Chembiochem : a European journal of chemical biology.

In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.

M. Niepel, K. Swinger, A. Lu, 2020, Cell chemical biology.

Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones.

Stephanie D. Geuns-Meyer, H. Gunaydin, H. Nguyen, 2012, The Journal of organic chemistry.

New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.

M. Martinelli, M. Faul, P. Reider, 2006, Organic letters.

Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.

T. Bush, Grace Chung, R. Radinsky, 2015, Journal of Medicinal Chemistry.

Novel sulfinyl imine ligands for asymmetric catalysis.

J. Ellman, L. Schenkel, 2003, Organic letters.

Novel sulfinyl imine ligands for asymmetric catalysis.

J. Ellman, L. Schenkel, 2003, Organic letters.

Application of P,N‐Sulfinyl Imine Ligands to Iridium‐Catalyzed Asymmetric Hydrogenation of Olefins.

J. Ellman, L. Schenkel, 2004 .

Application of P,N-sulfinyl imine ligands to iridium-catalyzed asymmetric hydrogenation of olefins.

J. Ellman, L. Schenkel, 2004, The Journal of organic chemistry.

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.

Roman Shimanovich, Angel Guzman-Perez, R. Fremeau, 2017, Journal of medicinal chemistry.

Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.

T. Bush, Marc Payton, Grace Chung, 2010, Cancer research.

Therapeutics , Targets , and Chemical Biology Preclinical Evaluation of AMG 900 , a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines

T. Bush, Marc Payton, Grace Chung, 2010 .

Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings.

I. Archibeque, Stephanie D. Geuns-Meyer, R. Emkey, 2013, Experimental hematology.

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

C. Stucky, B. Moyer, Stephanie D. Geuns-Meyer, 2016, Molecular pain.

A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.

M. Niepel, K. Swinger, K. Kunii, 2021, Cell chemical biology.

Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes

K. Swinger, Claudia Beck, D. Wegener, 2019, SLAS discovery : advancing life sciences R & D.

Antitumor efficacy in rats of CGP 19984, a thiazolidinedione derivative that inhibits luteinizing hormone secretion.

P. Sylvester, M. Ip, L. Schenkel, 1986, Cancer Research.

Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.

Stephanie D. Geuns-Meyer, N. Gavva, A. Boezio, 2014, Bioorganic & medicinal chemistry letters.

Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.

Xin Huang, Renee Emkey, A. Cheng, 2011, Journal of medicinal chemistry.

Abstract 1344: Small molecule inhibitor of CD38 modulates its intra- and extracellular functions leading to antitumor activity

M. Niepel, K. Kunii, V. Richon, 2021, Experimental and Molecular Therapeutics.

Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.

B. Moyer, Nagasree Chakka, A. Guzman-Perez, 2017, Bioorganic & medicinal chemistry letters.