Mohamed Aljarah

Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

E. Gorovits, A. Kolykhalov, Srinivas K. Battina, 2011, Journal of medicinal chemistry.

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

E. Gorovits, Yule Liu, A. Kolykhalov, 2011, Antimicrobial Agents and Chemotherapy.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

E. Gorovits, Yule Liu, A. Kolykhalov, 2010, Journal of medicinal chemistry.

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.

E. Gorovits, A. Brancale, A. Kolykhalov, 2010, Bioorganic & medicinal chemistry letters.

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

A. Kolykhalov, Srinivas K. Battina, J. Vernachio, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.

C. Périgaud, C. Mathé, Mohamed Aljarah, 2008, Bioorganic & medicinal chemistry.

Revisited 3′-Deoxy-3′-C-Methyl-β-D-Ribonucleoside Series

C. Périgaud, C. Mathé, G. Gosselin, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis of 3′-deoxy-3′-C-methyl-β-d-ribonucleoside analogs

C. Périgaud, C. Mathé, G. Gosselin, 2007 .

Pharmacodynamic Properties Replication with Excellent Pharmacokinetic Potent Inhibitor of Hepatitis C Virus-Methyl Guanosine , Is a C-′-Methyl-2 O 6-INX-08189 , a Phosphoramidate Prodrug of

E. Gorovits, Yule Liu, A. Kolykhalov, 2011 .