Wen Shuai

发表

High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.

Bo Sun, Chengyong Wu, Yuxi Wang, 2020, Biochemical and biophysical research communications.

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

Xiu-ying Hu, P. Xu, Rui Zhao, 2022, Frontiers in Pharmacology.

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.

Zhe-Sheng Chen, Dong-Hua Yang, Shengtao Xu, 2021, European journal of medicinal chemistry.

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.

Shengtao Xu, Jinyi Xu, Hong Yao, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.

Shengtao Xu, Hequan Yao, Jinyi Xu, 2019, European journal of medicinal chemistry.

Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.

Honghao Sun, Shengtao Xu, Hequan Yao, 2018, European journal of medicinal chemistry.

Routinely placing drainage tube in patients with anterior cervical surgery: is it really necessary?

Yang Liu, Y. Meng, Hao Liu, 2021, Chinese medical journal.

A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome.

K. Hayashi, M. Yamagishi, H. Higashida, 2013, Heart rhythm.

Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives.

Guan Wang, Yongya Wu, Yumeng Zhu, 2022, European journal of medicinal chemistry.

Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.

K. Hayashi, M. Yamagishi, H. Higashida, 2010, Heart rhythm.

Flexible and Energy-efficient Synaptic Transistor with Quasi-linear Weight Update Protocol by Inkjet Printing of Orientated Polar-electret/High-k Oxide Hybrid Dielectric

Guofu Zhou, Z. Fan, J. Rao, 2021 .

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.

Honghao Sun, Shengtao Xu, Hequan Yao, 2019, European journal of medicinal chemistry.

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain.

Shengtao Xu, Jinyi Xu, Hong Yao, 2019, Bioorganic chemistry.

Discovery of Novel 4-Arylisochromenes as Anticancer Agents Inhibiting Tubulin Polymerization.

Honghao Sun, Shengtao Xu, Hequan Yao, 2018, ACS medicinal chemistry letters.

Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy.

Duane D. Miller, L. Ouyang, Guan Wang, 2021, Journal of medicinal chemistry.

Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease.

L. Ouyang, Guan Wang, Qiu Sun, 2023, Journal of medicinal chemistry.

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

L. Ouyang, Guan Wang, Qiu Sun, 2023, European journal of medicinal chemistry.

Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.

L. Ouyang, Guan Wang, Weimin Li, 2022, Journal of medicinal chemistry.

Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.

Honghao Sun, Shengtao Xu, Hequan Yao, 2019, Bioorganic chemistry.

Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.

Zhe-Sheng Chen, Dong-Hua Yang, Honghao Sun, 2018, Journal of medicinal chemistry.

Unraveling the Design and Discovery of c-Jun N-Terminal Kinase Inhibitors and Their Therapeutic Potential in Human Diseases.

L. Ouyang, Guan Wang, Aoxue Wang, 2022, Journal of medicinal chemistry.

Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers.

L. Ouyang, Guan Wang, F. Lin, 2021, Journal of medicinal chemistry.

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.

O. Boutaud, J. Balser, S. Kupershmidt, 2009, Journal of molecular and cellular cardiology.

Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer.

L. Ouyang, Guan Wang, Aoxue Wang, 2023, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation.

D. Scurr, Chenbang He, M. Marlow, 2023, Journal of medicinal chemistry.

HERG Is Protected from Pharmacological Block by α-1,2-Glucosyltransferase Function*

P. C. Viswanathan, J. Balser, S. Kupershmidt, 2007, Journal of Biological Chemistry.

HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.

P. C. Viswanathan, J. Balser, S. Kupershmidt, 2007, The Journal of biological chemistry.

Developing potent LC3-targeting AUTAC tools for protein degradation with selective autophagy.

L. Ouyang, Guan Wang, Aoxue Wang, 2021, Chemical Communications.