John D. Trzupek

发表

Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation.

S. Danishefsky, Zhongping Tan, Cindy Kan, 2009, Journal of the American Chemical Society.

Epigenetic drugs that do not target enzyme activity.

D. Owen, John D. Trzupek, 2014, Drug discovery today. Technologies.

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Mark J. Mitton-Fry, J. D. Clark, M. Hegen, 2018, Journal of medicinal chemistry.

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

S. Knapp, O. Fedorov, M. Bunnage, 2016, Journal of medicinal chemistry.

A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.

D. Boger, W. Jin, S. Weir, 2007, Journal of the American Chemical Society.

Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.

D. Boger, F. Shiga, Mark S Tichenor, 2006, Journal of the American Chemical Society.

Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan.

V. Marathias, S. Danishefsky, Dongjoo Lee, 2010, Journal of the American Chemical Society.

Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization.

D. Boger, Steven P. Breazzano, Joie Garfunkle, 2010, Journal of the American Chemical Society.

Total synthesis of chloropeptin II (complestatin) and chloropeptin I.

D. Boger, S. Takizawa, Joie Garfunkle, 2009, Journal of the American Chemical Society.

Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.

D. Boger, T. V. Hughes, I. Hwang, 2004, Bioorganic & medicinal chemistry.

Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.

D. Boger, Karen S Macmillan, Mark S Tichenor, 2007, Journal of the American Chemical Society.

Asymmetric Total Synthesis of (+)- and ent-(-)-Yatakemycin (I) and Duocarmycin SA (II): Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer.

D. Boger, F. Shiga, Mark S Tichenor, 2007 .

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

D. Boger, J. Gottesfeld, John D. Trzupek, 2006, Nature chemical biology.

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.

Tiffany T. Howard, Carly A. Price, J. Hartley, 2004, Bioorganic & medicinal chemistry.

Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.

S. Wright, J. Mousseau, Chulho Choi, 2015, Organic letters.

Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet–Spengler reaction

S. Danishefsky, Chaomin Li, B. Crowley, 2010, Pure and applied chemistry. Chimie pure et appliquee.

Photochemical generation of ribose abasic sites in RNA oligonucleotides.

T. Sheppard, John D. Trzupek, 2005, Organic letters.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

S. Knapp, P. Biggin, O. Fedorov, 2015, Science Advances.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

S. Knapp, M. Bunnage, P. Fish, 2012, Journal of medicinal chemistry.

A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.

J. Hartley, Moses Lee, W. Pennington, 2005, Medicinal chemistry.

Total synthesis of chloropeptin II (complestatin) and chloropeptin I.

S. Takizawa, Joie Garfunkle, John D. Trzupek, 2009, Journal of the American Chemical Society.