Beijing Tan

发表

Utilization of hydrophilic-interaction LC to minimize matrix effects caused by phospholipids.

C. Holliman, T. McDonald, Andre Negahban, 2012, Bioanalysis.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

Application of the dried spot sampling technique for rat cerebrospinal fluid sample collection and analysis.

C. Holliman, Jianhua Liu, Brian Rago, 2011, Journal of pharmaceutical and biomedical analysis.

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.

J. Treadway, J. Pfefferkorn, W. Zavadoski, 2013, Bioorganic & medicinal chemistry letters.

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.

S. Wright, A. Kalgutkar, J. Pfefferkorn, 2010, Bioorganic & medicinal chemistry letters.

Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

Bo Feng, Zhuang Miao, A. Kalgutkar, 2011, Drug Metabolism and Disposition.

A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.

S. Wright, J. Pfefferkorn, J. Litchfield, 2012, Bioorganic & medicinal chemistry letters.

A Novel Relay Method for Determining Low-Clearance Values

Li Di, R Scott Obach, Yurong Lai, 2012, Drug Metabolism and Disposition.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method

Li Di, Jian Lin, R Scott Obach, 2013, Drug Metabolism and Disposition.

In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method

L. Di, Jian Lin, Karen Atkinson, 2013, Drug Metabolism and Disposition.