L. Zadjura

发表

Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.

N. Meanwell, D. Langley, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.

Zheng Yang, Fang Zhao, Timothy P Spicer, 2003, Journal of medicinal chemistry.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity

N. Meanwell, R. Colonno, J. Kadow, 2009, Journal of medicinal chemistry.

Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.

N. Meanwell, P. Shi, K. Yeung, 2013, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.

A. Marino, N. Meanwell, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.

A. Marino, N. Meanwell, I. Medina, 2009, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.

T. Spicer, N. Meanwell, P. Shi, 2009, Bioorganic & medicinal chemistry letters.

A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding

Zheng Yang, Tao Wang, Robert Fridell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.

A. Marino, N. Meanwell, R. Colonno, 2010, Journal of pharmaceutical sciences.

Preclinical pharmacokinetics of a novel HIV‐1 attachment inhibitor BMS‐378806 and prediction of its human pharmacokinetics

A. Marino, N. Meanwell, R. Colonno, 2005, Biopharmaceutics & drug disposition.

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.

T. Spicer, N. Meanwell, P. Shi, 2009, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.

T. Spicer, N. Meanwell, P. Shi, 2013, Bioorganic & medicinal chemistry letters.