G. Giardina

发表

Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Journal of medicinal chemistry.

Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.

G. Dondio, M. Sbacchi, V. Vecchietti, 1994, Journal of medicinal chemistry.

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.

A. Giordani, V. Vecchietti, G. Clarke, 1991, Journal of medicinal chemistry.

Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.

H. Sarau, R. Ames, J. Foley, 2001, European journal of pharmacology.

Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.

H. Sarau, J. Foley, F. Barone, 2002, The Journal of pharmacology and experimental therapeutics.

The antitussive activity of delta-opioid receptor stimulation in guinea pigs.

D. Underwood, G. Dondio, P. Petrillo, 2000, The Journal of pharmacology and experimental therapeutics.

2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

H. Sarau, J. Foley, A. Medhurst, 1996, Journal of medicinal chemistry.

Central and peripheral analgesic agents: chemical strategies for limiting brain penetration in kappa-opioid agonists belonging to different chemical classes.

M. Sbacchi, V. Vecchietti, G. Clarke, 1995, Farmaco.

Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)

M. Scheideler, P. Zaratin, P. Petrillo, 2004, Journal of Pharmacology and Experimental Therapeutics.

Modification of Nociception and Morphine Tolerance by the Selective Orl-1 Antagonist Sb-612111 Running Title: Characterization of a Selective Orl-1 Antagonist

M. Scheideler, P. Zaratin, P. Petrillo, 2022 .

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

H. Sarau, J. Foley, F. Barone, 2000, The Journal of pharmacology and experimental therapeutics.

Evidence that the proposed novel human "neurokinin-4" receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin.

D. Y. Wang, H. Sarau, J. Foley, 2000, Molecular pharmacology.

Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists.

H. Sarau, S. Gagliardi, M. Artico, 1999, Farmaco.

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.

H. Sarau, A. Medhurst, C. Farina, 1997, Journal of medicinal chemistry.

Potent and selective non-peptidic delta opioid ligands based on the novel heterocycle-condensed octahydroisoquinoline structure

G. Dondio, P. Petrillo, V. Vecchietti, 1994, Regulatory Peptides.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).

B. Imbimbo, G. Villetti, G. Dondio, 2007, Journal of medicinal chemistry.

Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis.

D. Brooks, G. Dondio, M. Gellai, 1993, The Journal of pharmacology and experimental therapeutics.

4,5-Functionalized 6-Phenyl-3(2H)-pyridazinones: Synthesis and Evaluation of Antinociceptive Activity.

V. D. Piaz, M. Giovannoni, D. Barlocco, 1996 .

4,5-Functionalized 6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity

V. D. Piaz, M. Giovannoni, D. Barlocco, 1996 .

Lead generation and lead optimisation approaches in the discovery of selective, non-peptide ORL-1 receptor agonists and antagonists

I. Peretto, S. Ronzoni, G. Giardina, 2001 .

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).

H. Sarau, J. Foley, A. Medhurst, 1999, Journal of medicinal chemistry.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).

C. Bigogno, B. Imbimbo, G. Villetti, 2007, Journal of medicinal chemistry.

Recent advances in neurokinin-3 receptor antagonists

L. Raveglia, G. Giardina, M. Grugni, 2000 .

Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.

H. Sarau, J. Foley, N. Elshourbagy, 1997, The Journal of pharmacology and experimental therapeutics.

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.

B. Imbimbo, G. Giardina, 2011, Current topics in medicinal chemistry.

Substituted 1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: A Novel Class of Very Potent Antinociceptive Agents with Varying Degrees of Selectivity for and μ Opioid Receptors.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992 .

Enantiospecificity of kappa receptors: comparison of racemic compounds and active enantiomers in two novel series of kappa agonist analgesics.

G. Dondio, M. Sbacchi, V. Vecchietti, 1992, Chirality.

Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.

F E Blaney, H. Sarau, F. Blaney, 2001, Journal of medicinal chemistry.

(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.

M. Sbacchi, V. Vecchietti, G. Clarke, 1991, Journal of medicinal chemistry.

THE ROLE OF THE “SPACER" IN THE OCTAHYDROISOQUINOLINE SERIES: DISCOVERY OF SB 213698, A NON-PEPTIDIC, POTENT AND SELECTIVE DELTA OPIOID AGONIST

G. Dondio, P. Petrillo, V. Vecchietti, 1995 .