K. Sharpless

发表

Rapid Diversity‐Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors

David S Goodsell, Chi-Huey Wong, Arthur J Olson, 2003, Chembiochem : a European journal of chemical biology.

A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process

M. Finn, J. Svendsen, E. Jacobsen, 1989 .

Enhanced kinetic resolution and enzyme-like shape selectivity

P. Carlier, W. Mungall, K. Sharpless, 1988 .

CONFORMATIONAL STUDY OF CINCHONA ALKALOIDS - A COMBINED NMR, MOLECULAR MECHANICS, AND X-RAY APPROACH

H. Wynberg, J. Svendsen, R. Kellogg, 1989 .

The structure of osmium tetraoxide-cinchona alkaloid complexes

S. Bott, J. Svendsen, E. Jacobsen, 1989 .

Click chemistry connections for functional discovery

H. Kolb, M. Finn, K. Sharpless, 2022, Nature Synthesis.

A VALUABLE TOOL FOR PEPTIDE AND PROTEIN MODIFICATION

H. Kolb, V. Fokin, K. Sharpless, 2016 .

Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs.

J. Moses, Shoujun Sun, C. Smedley, 2023, Chem.

"On water": unique reactivity of organic compounds in aqueous suspension.

M. Finn, H. Kolb, K. Sharpless, 2005, Angewandte Chemie.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

M. G. Finn, Hartmuth C. Kolb, K. Barry Sharpless, 2001, Angewandte Chemie.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

M. Finn, H. Kolb, K. Sharpless, 2001 .

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

I. Wilson, J. Kelly, E. Powers, 2013, Journal of the American Chemical Society.

Click chemistry in materials synthesis. 1. Adhesive polymers from copper‐catalyzed azide‐alkyne cycloaddition

Philipp Holzer, D. Díaz, M. Finn, 2004 .

In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

Chi-Huey Wong, Benoit Colasson, Chi‐Huey Wong, 2004, Angewandte Chemie.

Multivalent, bifunctional dendrimers prepared by click chemistry.

C. Hawker, M. Finn, K. Sharpless, 2005, Chemical communications.

Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: controlling selectivity.

K. Sharpless, V. Fokin, Sukbok Chang, 2007, Angewandte Chemie.

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

P. Taylor, P. Carlier, M. Finn, 2002, Angewandte Chemie.

Copper(I)-catalyzed cycloaddition of organic azides and 1-iodoalkynes.

V. Fokin, J. Hein, L. Krasnova, 2010, Angewandte Chemie.

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure

P. Taylor, V. Fokin, C. Green, 2018, The Journal of Pharmacology and Experimental Therapeutics.

A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry

Chi‐Huey Wong, K. Sharpless, V. Fokin, 2003 .

In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

Zoran Radić, Palmer Taylor, P. Taylor, 2005, Journal of the American Chemical Society.

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification

I. Wilson, N. Wu, Jia Xie, 2019, Nature Communications.

Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization.

A. Olson, K. Sharpless, V. Fokin, 2006, Journal of medicinal chemistry.

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Wentao Chen, Stefano Forli, D. E. Mortenson, 2018, Journal of the American Chemical Society.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

H. Kolb, K. Sharpless, M. Finn, 2001, Angewandte Chemie.

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

I. Wilson, E. Powers, N. Grimster, 2013, Journal of the American Chemical Society.

Inhibitors of HIV-1 protease by using in situ click chemistry.

William Lindstrom, Arthur J Olson, John H Elder, 2006, Angewandte Chemie.

Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.

Jian‐mei Lu, Yi Liu, Feng Zhou, 2017, Nature chemistry.

Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry.

L. Krasnova, Jiajia Dong, K. Sharpless, 2014, Angewandte Chemie.

SuFEx-based synthesis of polysulfates.

K. Sharpless, V. Fokin, J. Oakdale, 2014, Angewandte Chemie.

A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an "F-SO2 +" Donor of Unprecedented Reactivity, Selectivity, and Scope.

Jiajia Dong, Tiancheng Ma, Qian Yang, 2018, Angewandte Chemie.

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.

K. Sharpless, David J. D. Wilson, B. Parker, 2018, Angewandte Chemie.

The growing impact of click chemistry on drug discovery.

H. Kolb, K. Sharpless, K. B. Sharpless, 2003, Drug discovery today.

Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases*

P. Taylor, V. Fokin, C. Green, 2012, The Journal of Biological Chemistry.

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases*

P. Taylor, M. Katalinić, K. Sharpless, 2011, The Journal of Biological Chemistry.

Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub.

K. Sharpless, J. Moses, Suhua Li, 2017, Angewandte Chemie.

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

D. Wolan, K. Sharpless, Stefano Forli, 2019, Proceedings of the National Academy of Sciences.

Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.

P. Taylor, Y. Bourne, P. Marchot, 2016, Journal of the American Chemical Society.

Click chemistry in materials synthesis. III. Metal‐adhesive polymers from Cu(I)‐catalyzed azide–alkyne cycloaddition

D. Díaz, M. Finn, K. Sharpless, 2007 .

Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach.

G. Siuzdak, S. Trauger, E. Kalisiak, 2009, Journal of the American Chemical Society.

Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.

Wentao Chen, J. Kelly, K. Sharpless, 2016, Angewandte Chemie.

Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.

P. Taylor, N. Grimster, V. Fokin, 2012, Journal of the American Chemical Society.

Polytriazoles as Copper(I)‐Stabilizing Ligands in Catalysis.

K. Barry Sharpless, Valery V. Fokin, K. Sharpless, 2004 .

In situ click chemistry: enzyme inhibitors made to their own specifications.

Zoran Radić, Palmer Taylor, P. Taylor, 2004, Journal of the American Chemical Society.

Ligand‐Accelerated Catalysis

D. J. Berrisford, C. Bolm, K. Sharpless, 1995 .

A Highly Efficient Aminohydroxylation Process

K. Sharpless, A. Rubin, K. B. Sharpless, 1997 .

Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis

L. Eckmann, T. Lauwaet, K. Sharpless, 2020, PLoS neglected tropical diseases.