A. Sitlani

发表

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants*

M. Bottomley, R. De Francesco, R. Cummings, 2009, Journal of Biological Chemistry.

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of one figure. Published, JLR Papers in Press, March 19, 2008.

R. Cummings, D. Wisniewski, S. Wright, 2008, Journal of Lipid Research.

Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

M. Forrest, G. Harris, C. Freund, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010, Journal of Lipid Research.

Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.

Amjad Ali, M. Forrest, G. Harris, 2008, Bioorganic & medicinal chemistry.

DNA-binding domains of Fos and Jun do not induce DNA curvature: an investigation with solution and gel methods.

D. Crothers, A. Sitlani, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.

D. Zaller, Amjad Ali, Douglas K. Miller, 2004, Journal of medicinal chemistry.

DNA photocleavage by phenanthrenequinone diimine complexes of rhodium(III): shape-selective recognition and reaction

J. Barton, A. Pyle, E. Long, 1992 .

Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions*

W. Geissler, G. Harris, S. Pandit, 2002, The Journal of Biological Chemistry.

Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.

M. Bottomley, R. Francesco, R. Cummings, 2008 .

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.

D. Zaller, Amjad Ali, Douglas K. Miller, 2005, Bioorganic & medicinal chemistry letters.

Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry.

R. Hendrickson, D. Rader, N. Yates, 2012, Clinical chemistry.

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

J. Chen, G. O'neill, Sheng-ping Wang, 2013, Journal of Lipid Research.

Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism

Amjad Ali, W. Geissler, G. Harris, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Enantiospecific palindromic recognition of 5'-d(CTCTAGAG)-3' by a novel rhodium intercalator: analogies to a DNA-binding protein

J. Barton, C. M. Dupureur, A. Sitlani, 1993 .

Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation*

R. De Francesco, R. Cummings, D. Wisniewski, 2007, Journal of Biological Chemistry.

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.

D. Zaller, Amjad Ali, Douglas K. Miller, 2007, Bioorganic & medicinal chemistry letters.

Fos and Jun do not bend the AP-1 recognition site.

D. Crothers, A. Sitlani, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Global structure and mechanical properties of a 10-bp nucleosome positioning motif.

D. Crothers, J. Lapham, A. Sitlani, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical characterization of cholesteryl ester transfer protein inhibitors

Nadine H. Elowe, B. Hubbard, M. Garcia-Calvo, 2010, Journal of Lipid Research.

An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes

N. Geoghagen, L. Mitnaul, D. Johns, 2012, International journal of biological sciences.

Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.

Scott K. Smith, D. Zaller, Amjad Ali, 2005, Bioorganic & medicinal chemistry letters.

Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

P. Monaci, A. Carfi, E. Fattori, 2012, Journal of Lipid Research.

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Lora Hamuro, Jayne Chin, L. Mitnaul, 2011, Journal of Lipid Research.

A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

J. Condra, M. Bottomley, R. Cummings, 2010, The Journal of Biological Chemistry.

Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.

G. Harris, J. Santoro, A. Sitlani, 2001, Analytical biochemistry.

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

E. Settembre, M. Bottomley, A. Carfi, 2011, EMBO reports.

Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

J. W. Becker, S. Soisson, Alan D. Adams, 2008, Proceedings of the National Academy of Sciences.

PCSK 9 is not involved in the degradation of LDL receptors and BACE 1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010 .

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010, Journal of Lipid Research.

Clinical and Regulatory Challenges and Opportunities for Monoclonal Antibodies in Low- and Middle-Income Countries: Lessons from COVID-19 and Beyond

Vincent Muturi-Kioi, Lisa Gieber, S. Malhotra, 2023, Pharmaceutical Medicine.

Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

P. Monaci, A. Carfi, E. Fattori, 2012, Journal of Lipid Research.