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Direct photocapture of bromodomains using tropolone chemical probes

R. Denny, M. Pletcher, E. Hett, 2015 .

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

M. Ammirati, D. Craik, David A. Price, 2014, Chemistry & biology.

Pharmacological characterization of the first in class clinical candidate PF‐05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose‐dependent insulin secretion ex vivo

P. Loria, S. V. Straub, S. Bhattacharya, 2016, British journal of pharmacology.

CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases*

Christopher S. Poss, J. Kath, W. Brissette, 2003, Journal of Biological Chemistry.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Kevin Lee, R. Denny, M. Pletcher, 2015, Chemistry & biology.

Potent small molecule CCR1 antagonists.

Christopher S. Poss, J. Kath, W. Brissette, 2004, Bioorganic & medicinal chemistry letters.

The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template.

J. Kath, R. Gladue, W. H. Martin, 2004, Bioorganic & medicinal chemistry letters.

Rational design, synthesis, and X-ray structure of renin inhibitors with extended P1 sidechains

M. Ammirati, D. Danley, G. Schulte, 1995 .

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

K. Fennell, O. Fedorov, P. Loria, 2022, Journal of medicinal chemistry.

Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.

P. Loria, D. Hepworth, S. Bhattacharya, 2015, ACS Medicinal Chemistry Letters.

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.

M. Ammirati, David A. Price, S. Liras, 2017, Journal of the American Chemical Society.

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

D. Danley, R. McPherson, J. Treadway, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Benzimidazolone p38 inhibitors.

C. Gabel, T. Carty, John T Barberia, 2004, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.

R. Denny, P. Brennan, M. Pletcher, 2017, Journal of medicinal chemistry.

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.

P. Loria, D. Hepworth, S. Bhattacharya, 2014, ACS medicinal chemistry letters.

Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.

R. McPherson, J. Treadway, E. M. Gibbs, 1998, Journal of medicinal chemistry.

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

P. Loria, J. Bauman, David A. Price, 2022, Journal of medicinal chemistry.

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.

L. Michael, T. Goosen, M. Tu, 2013, Bioorganic & medicinal chemistry letters.

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

J. Pandit, K. Parris, David A. Price, 2020, Journal of medicinal chemistry.

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

Z. Hendsch, B. Posner, D. Kung, 2012, Bioorganic & medicinal chemistry letters.

Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor

James L. Hougland, G. Koob, B. Holst, 2023, The Journal of Pharmacology and Experimental Therapeutics.

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

Z. Hendsch, B. Posner, D. Kung, 2012, Bioorganic & medicinal chemistry letters.