R. J. Chorvat

发表

Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies.

C. Hodge, Z. Wasserman, P. Aldrich, 1999, Journal of medicinal chemistry.

22-Hydroxycholesterol derivatives as HMG CoA reductase suppressors and serum cholesterol lowering agents.

J. Miller, E. Rohrbacher, B. N. Desai, 1985, Journal of medicinal chemistry.

2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action.

R. Earl, C. Teleha, S. Tam, 1998, Journal of medicinal chemistry.

Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.

R. Earl, D. Rominger, M. Pierdomenico, 1998, The Journal of pharmacology and experimental therapeutics.

Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.

E. D. De Souza, F. Hobbs, A. Cocuzza, 1999, Journal of medicinal chemistry.

The synthesis of annelated 3-cyano-2-pyridones

R. J. Chorvat, S. E. Radak, 1980 .

Total synthesis of 2-azaestratrienes

J. Palmer, R. Pappo, R. J. Chorvat, 1978 .

Synthesis and unexpected reactions of 2‐Hydroxy‐3‐pyridinylacetic hydrazides. Formation of 2H‐Pyrrolo[2,3‐b]pyridin‐2‐ones

C. Teleha, R. J. Chorvat, R. Greenberg, 1998 .

Synthesis of 4-phenyl-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-ones (4-phenylazaphenothiazines) via activated dimethylformamide reagents

B. N. Desai, R. J. Chorvat, S. E. Radak, 1987 .

Synthesis of 3,9-dihydro-3,9-dioxo-2H-indeno[2,1-c] pyridine-4-carbonitriles

B. N. Desai, R. J. Chorvat, 1980 .

Synthesis of 4-aryl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyrazines

Robert J. Chorvat, Kurt J. Rorig, K. Rorig, 1988 .

Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.

C. Hodge, Y. Wong, F. Hobbs, 1999, Journal of medicinal chemistry.

Syntheses of substituted phosphetanes and related derivatives

S. Cremer, R. J. Chorvat, 1967 .

Pyramidal inversion in substituted phosphetanes

S. Cremer, R. J. Chorvat, C. H. Chang, 1968 .

Stereochemistry of the base decomposition of phosphetanium bromides

B. C. Trivedi, S. Cremer, R. J. Chorvat, 1969 .

Novel rearrangement of 6β,19-oxido-2,17-dihydroxyandrosta-1,4-dien-3-one

R. Bible, R. J. Chorvat, L. Swenton, 1975 .

2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action.

R. Earl, C. Teleha, S. Tam, 1998, Journal of medicinal chemistry.

Synthesis of 2-azaestratrienes

R. Pappo, R. J. Chorvat, 1976 .

Linopirdine: Pharmacology of a Neurotransmitter Release Enhancer

B. S. Brown, R. Zaczek, R. J. Chorvat, 1997 .

The synthesis of 2-azasteroids

R. Pappo, R. J. Chorvat, 1972 .

Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone.

M. Brown, J. Goldstein, J. Faust, 1978, Proceedings of the National Academy of Sciences of the United States of America.

THE TOTAL SYNTHESIS OF (+-)-2-AZAESTRADIOL-3-METHYL ETHER

R. Pappo, R. J. Chorvat, 1975 .

Memory-Enhancing Drugs

R. Zaczek, R. J. Chorvat, 2000 .

Mono- and bis(aminomethyl)phenylacetic acid esters as short-acting antiarrhythmic agents. 2.

V V Ranade, V. Ranade, D. Stout, 1993, Journal of medicinal chemistry.

Peripherally restricted CB1 receptor blockers.

Robert J Chorvat, R. J. Chorvat, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d3 )butanamide-d5 , octadeuterated JD5037.

M. R. Iyer, G. Kunos, R. Cinar, 2017, Journal of labelled compounds & radiopharmaceuticals.

JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.

Jennifer Berbaum, J. Berbaum, Robert J Chorvat, 2012, Bioorganic & medicinal chemistry letters.

Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.

J. Deschamps, J. Liow, R. Innis, 2012, Cell metabolism.

Acetylcholine-releasing agents as cognition enhancers. Structure-activity relationships of pyridinyl pendant groups on selected core structures.

D. Brittelli, R. Earl, M. A. Wuonola, 1992 .

Ion channel modulators that enhance acetylcholine release: potential therapies for Alzheimer's disease.

B. S. Brown, R. Zaczek, R. J. Chorvat, 1998, Expert opinion on investigational drugs.

acetylcholine release: potential therapies for Alzheimer's disease

B. S. Brown, R. Zaczek, R. J. Chorvat, 1998 .

Facile synthesis of 3.beta.-hydroxy-5.alpha.-cholest-8(14)-en-15-one 3-acetate

B. N. Desai, R. J. Chorvat, 1979 .

Preclinical toxicity evaluation of JD5037, a peripherally restricted CB1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis.

G. Kunos, R. Cinar, V. Kale, 2019, Regulatory toxicology and pharmacology : RTP.

Peripherally restricted CB1 receptor blockers.

R. J. Chorvat, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, benzodiazepine receptor binding, and anticonvulsant activity of 2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitriles.

J. Hirsch, S. Tenen, B. N. Desai, 1983, Journal of medicinal chemistry.