E. Marczak

发表

Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

D. Rognan, S. Salvadori, G. Balboni, 2009, Bioorganic & medicinal chemistry letters.

Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

S. Salvadori, G. Balboni, A. Abell, 2010, Bioorganic & medicinal chemistry letters.

Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.

Qiang Li, Y. Tsuda, Y. Okada, 2007, Bioorganic & medicinal chemistry.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.

Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.

S. Salvadori, G. Balboni, Y. Sasaki, 2010, Bioorganic & medicinal chemistry.

Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.

Xiaoyuan Chen, S. Salvadori, G. Balboni, 2008, Journal of medicinal chemistry.

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).

S. Salvadori, G. Balboni, F. Porreca, 2008, Bioorganic & medicinal chemistry.

[N-Allyl-Dmt1]-Endomorphins Are μ-Opioid Receptor Antagonists Lacking Inverse Agonist Properties

Y. Tsuda, Y. Okada, S. Bryant, 2007, Journal of Pharmacology and Experimental Therapeutics.

Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1

Y. Fujita, Y. Tsuda, Y. Okada, 2006, Pharmacology Biochemistry and Behavior.

New antihypertensive peptides isolated from rapeseed

A. Lipkowski, H. Fujita, M. Yoshikawa, 2003, Peptides.

Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice

A. Lipkowski, M. Yoshikawa, K. Ohinata, 2006, Peptides.

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, C. Trapella, 2008, Journal of medicinal chemistry.

The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol.

W. A. Wilson, Qiang Li, Y. Okada, 2008, Alcohol and alcoholism.

PHARMACOLOGY AND CELL METABOLISM The Novel µ-Opioid Receptor Antagonist, (N-Allyl-Dmt 1 )Endomorphin-2, Attenuates the Enhancement of GABAergic Neurotransmission by Ethanol

W. A. Wilson, Qiang Li, Y. Okada, 2009 .

Antihypertensive properties of spinach leaf protein digests.

Y. Kawamura, M. Yoshikawa, H. Usui, 2004, Journal of agricultural and food chemistry.

Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco.

Masaaki Yoshikawa, Hachiro Usui, M. Yoshikawa, 2003, Journal of agricultural and food chemistry.

Inhibition of the development of morphine tolerance by a potent dual μ-/δ-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph

S. Salvadori, G. Balboni, L. Lazarus, 2008, Pharmacology Biochemistry and Behavior.

New series of potent δ-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif

Y. Fujita, Y. Tsuda, Y. Okada, 2005 .

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

S. Salvadori, G. Balboni, Ralph E. Wilson, 2009, European journal of pharmacology.

Bifunctional [2‘,6‘-Dimethyl-l-tyrosine1]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Y. Tsuda, Y. Okada, A. Miyazaki, 2007 .

Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK1 receptor

Masashi Iwasaki, A. Lipkowski, M. Yoshikawa, 2010, Peptides.

Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans

S. Kleeberger, D. Zeldin, N. Brown, 2012, Pharmacogenetics and genomics.

Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.

S. Salvadori, G. Balboni, C. Trapella, 2009, Journal of medicinal chemistry.

Protein hydrolysates for oral tolerance.

B. Gajkowska, M. Walski, E. Marczak, 2000, Biofactors.

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

S. Salvadori, G. Balboni, Ralph E. Wilson, 2009, European journal of pharmacology.

Inhibition of the development of morphine tolerance by a potent dual μ-/δ-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph

S. Salvadori, G. Balboni, L. Lazarus, 2008, Pharmacology Biochemistry and Behavior.

Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Y. Tsuda, Y. Okada, A. Miyazaki, 2007, Journal of Medicinal Chemistry.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.

Potent Dmt-Tic Pharmacophoric d- and -Opioid Receptor Antagonists

S. Salvadori, Y. Fujita, Y. Tsuda, 2005 .