K. Ngu

发表

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

D. Shuster, J. Macor, J. Yanchunas, 2020, Journal of medicinal chemistry.

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.

J. Barrish, M. Blanar, Rongan Zhang, 2008, Journal of medicinal chemistry.

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.

M. Kirby, Saleem Ahmad, G. Chandrasena, 2004, Bioorganic & medicinal chemistry letters.

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

K. J. Yost, M. Kirby, N. Grazier, 2001, Journal of medicinal chemistry.

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.

E. Janovitz, D. Longhi, Christine S. Huang, 2016, Journal of Medicinal Chemistry.

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

J. Macor, N. Murugesan, Z. Gu, 2005, Bioorganic & medicinal chemistry letters.

Selective Solid Phase Synthesis of Ureas and Hydantoins from Common Phenyl Carbamate Intermediates

D. Patel, Xiao-yi Xiao, K. Ngu, 1997 .

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.

C. S. Madsen, Shaobin Zhuang, J. Robl, 2007, Bioorganic & medicinal chemistry letters.

Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors

J. Skotnicki, J. Levin, M. Navre, 1998 .

A New and Efficient Solid Phase Synthesis of Hydroxamic Acids.

D. Patel, K. Ngu, 1997, The Journal of organic chemistry.

An effective synthesis of N-(9-fluorenylmethyloxycarbonyl) .alpha.-amino aldehydes from S-benzyl thioesters

K. Ngu, P. Ho, 1993 .

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Saleem Ahmad, C. S. Madsen, Xing Chen, 2011, Bioorganic & medicinal chemistry letters.

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.

Jinping Gan, Saleem Ahmad, Ge Zhang, 2010, Bioorganic & medicinal chemistry letters.

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.

J. Barrish, E. Janovitz, D. Longhi, 2014, Journal of medicinal chemistry.

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Saleem Ahmad, C. S. Madsen, Xing Chen, 2011, Bioorganic & medicinal chemistry letters.