G. Mikkelsen

发表

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

C. Bundgaard, C. Christoffersen, B. Bang-Andersen, 2010, Journal of medicinal chemistry.

The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors.

C. Bundgaard, G. Smith, G. Mikkelsen, 2006, Bioorganic & medicinal chemistry letters.

The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors.

C. Christoffersen, S. Wren, A. Mørk, 2004, Bioorganic & medicinal chemistry letters.

Aglycon mimicking: Glycoside bond cleavage transition state mimics based on hydroxypyrrolidine inhibitors

M. Sierks, M. Bols, I. Lundt, 1995 .

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.

K. G. Jensen, C. Christoffersen, B. Bang-Andersen, 2012, Bioorganic & medicinal chemistry letters.

Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.

M. Langgård, C. Bundgaard, B. Bang-Andersen, 2011, Journal of medicinal chemistry.

Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.

M. Hentzer, P. Dokurno, A. Surgenor, 2021, Journal of Medicinal Chemistry.

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.

M. Hentzer, D. S. Williamson, I. Chen, 2017, Bioorganic & medicinal chemistry letters.

Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.

A. Ritzén, R. Brodbeck, Andreas Ritzén, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.

M. Langgård, B. Bang-Andersen, M. Kreilgaard, 2015, Bioorganic & medicinal chemistry letters.

Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.

B. Bang-Andersen, L. Torup, L. Brennum, 2010, Bioorganic & medicinal chemistry letters.