E. Usuki

发表

Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes.

A. Parkinson, R. Pearce, E. Usuki, 1996, Chemical research in toxicology.

Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: is HPTP an intermediate?

C. J. Van der Schyf, G. Fraser, R. Riker, 1997, Life sciences.

Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.

K. Igarashi, M. Fukui, F. Kasuya, 1995, Life sciences.

Haloperidol-Derived Pyridinium Metabolites

S. Pond, C. J. Schyf, N. Castagnoli, 1998 .

MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.

K. Igarashi, N. Castagnoli, H. Rollema, 1994, The Journal of pharmacology and experimental therapeutics.

Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon.

C. J. Van der Schyf, D. Eyles, S. Pond, 1996, Life sciences.

Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril.

Mark D. Johnson, A. Schmitt-Hoffmann, A. Parkinson, 2012, Journal of pharmaceutical sciences.

CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

D. Boykin, D. Zeldin, J. Hall, 2006, Drug Metabolism and Disposition.

Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins.

R. Riker, K. Igarashi, K. Castagnoli, 1999, Polish Journal of Pharmacology.

Metabolic studies on haloperidol and its tetrahydropyridinyl dehydration product (HPTP) in C57BL/6 mouse brain preparations

J. Bloomquist, K. Castagnoli, C. J. Schyf, 2009, Neurotoxicity Research.

Metabolism of haloperidol and its tetrahydropyridine dehydration product HPTP.

N. Castagnoli, E. Usuki, C. J. van der Schyf, 1998, Drug metabolism reviews.

In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450

A. Parkinson, B. Ogilvie, P. Yerino, 2019, Drug-Drug Interactions.

An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes

A. Nassar, A. Parkinson, B. Ogilvie, 2009, Drug Metabolism and Disposition.

Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression.

Mark D. Johnson, P. Lord, M. McMillian, 2007, Chemical research in toxicology.