I. Hayakawa

发表

Thienopyridine and benzofuran derivatives as potent anti-tumor agents possessing different structure-activity relationships.

T. Agatsuma, H. Furukawa, I. Hayakawa, 2004, Bioorganic & medicinal chemistry letters.

4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as potent anti-tumor agents.

T. Agatsuma, H. Furukawa, S. Naruto, 2004, Bioorganic & medicinal chemistry letters.

Multi-valent polymer of vancomycin: enhanced antibacterial activity against VRE

T. Kinumi, D. Uemura, H. Arimoto, 1999 .

Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

M. Takagi, N. Imamoto, T. Usui, 2013, ACS chemical biology.

Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules

T. Usui, V. Rodionov, D. Gupta, 2017, Molecular biology of the cell.

Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus isolates from Japan and China.

M. Tanaka, K. Sato, Y. Zhang, 1995, Journal of medical microbiology.

Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method.

T. Nishino, M. Tanaka, K. Sato, 1996, The Journal of antimicrobial chemotherapy.

Development of a novel inducer of protein-protein interactions based on aplyronine A.

H. Kigoshi, Atsuhiro Takano, Takayuki Ohyoshi, 2018, Chemical communications.

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions.

S. Matsumoto, H. Kigoshi, Kenichi Kobayashi, 2016, Organic & biomolecular chemistry.

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization.

T. Usui, A. Sakakura, H. Kigoshi, 2016, Bioorganic & medicinal chemistry.

Inhibition of DNA gyrase by optically active ofloxacin

I. Hayakawa, M. Imamura, S. Shibamura, 1987, Antimicrobial Agents and Chemotherapy.

Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor.

T. Usui, A. Sakakura, Daisuke Takao, 2020, ACS medicinal chemistry letters.

Absolute stereochemistry of halichlorine; A potent inhibitor of VCAM-1 induction

M. Kuramoto, D. Uemura, H. Arimoto, 1998 .

Synthesis and Biological Evaluation of Benzothiazole Derivatives as Potent Antitumor Agents.

T. Agatsuma, H. Furukawa, N. Hayashi, 2005 .

Catalytic enantioselective Hosomi-Sakurai reaction of α-ketoesters promoted by chiral copper(ii) complexes.

A. Sakakura, I. Hayakawa, Yutaro Niwa, 2019, Chemical communications.

A library synthesis of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as anti-tumor agents.

T. Agatsuma, H. Furukawa, S. Naruto, 2004, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P1 site

S. Miyamoto, Y. Yabe, A. Kasuya, 1999 .

Mechanism of differential activities of ofloxacin enantiomers

I. Morrissey, M. Bures, A. Yoshida, 1996, Antimicrobial agents and chemotherapy.

Regioselective dmad-insertion reaction of silyl dienol ether of γ-pyrone under catalyst- and heating-free conditions

A. Sakakura, Hiromi Ota, K. Mitsudo, 2017 .

Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents.

T. Agatsuma, H. Furukawa, N. Hayashi, 2005, Bioorganic & medicinal chemistry letters.

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling.

Yuta Suzuki, M. Ueda, H. Kigoshi, 2008, Organic letters.

Antimicrobial activity of DU-6681a, a parent compound of novel oral carbapenem DZ-2640

M. Tanaka, K. Sato, I. Hayakawa, 1997, Antimicrobial agents and chemotherapy.

Synthesis and evaluation of 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic acid ethyl ester derivatives as potent antitumor agents.

T. Agatsuma, I. Hayakawa, Rieko Shioya, 2005, Chemical & pharmaceutical bulletin.

Practical Syntheses of EnantiomericallyPure Key Intermediates of Opioid Receptor-like 1 (ORL1)Antagonists

H. Kigoshi, O. Okamoto, T. Yoshizumi, 2009 .

Three new alkaloids, convolutamines F and G, and convolutamydine E, from the Floridian marine bryozoan Amathia convoluta

M. Hayashi, K. Komiyama, G. Pettit, 1999 .

Toward the synthesis of γ-pyrone-containing natural products: diastereoselective aldol-type reaction of a γ-pyrone

T. Sengoku, H. Kigoshi, I. Hayakawa, 2012 .

Total synthesis of auripyrones A and B and determination of the absolute configuration of auripyrone B.

K. Suenaga, H. Kigoshi, I. Hayakawa, 2010, Angewandte Chemie.

Toward the Synthesis of SB-203207: Construction of Four Contiguous Nitrogen-Containing Stereogenic Centers.

A. Sakakura, I. Hayakawa, Anna Nagayasu, 2019, The Journal of organic chemistry.

Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids.

H. Kigoshi, I. Hayakawa, K. Niida, 2015, Chemical communications.

Total synthesis and biological evaluation of auripyrones A and B

K. Suenaga, H. Kigoshi, I. Hayakawa, 2012 .

Synthesis of the tricyclic core of halichlorine

D. Uemura, H. Arimoto, I. Hayakawa, 2004 .

Revised structure of zamamistatin

H. Kigoshi, T. Teruya, I. Hayakawa, 2006 .

Toward the Synthesis of Paspaline-Type Indole-Terpenes: Stereoselective Construction of Core Scaffold with Contiguous Asymmetric Quaternary Carbon Centers.

A. Sakakura, I. Hayakawa, Naochika Matsumaru, 2021, The Journal of organic chemistry.

Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine.

Dongwon Yoo, A. Sakakura, H. Kigoshi, 2019, Organic letters.

Synthetic study on 13-oxyingenol : construction of the full carbon framework

H. Kigoshi, Takayuki Ohyoshi, I. Hayakawa, 2007 .

Total Synthesis of Biselide E, a Marine Polyketide.

Yu Onozaki, H. Kigoshi, Takayuki Ohyoshi, 2017, Organic letters.

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound.

Yuichiro Hirayama, H. Kigoshi, Kenichi Kobayashi, 2012, Organic letters.

Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin

A. Sakakura, K. Suenaga, H. Kigoshi, 2006 .

Marine cytotoxic macrolides haterumalides and biselides, and related natural products.

H. Kigoshi, I. Hayakawa, 2007, Chemical record.

Synthetic Studies towards Optically Active 13-Oxyingenol via Asymmetric Cyclopropanation

H. Kigoshi, Yamato Miyazawa, Takayuki Ohyoshi, 2011 .

Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus

M. Tanaka, Y. Onodera, Y. Uchida, 1997, Antimicrobial agents and chemotherapy.

Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa

K. Hoshino, K. Sato, A. Kitamura, 1995, Antimicrobial agents and chemotherapy.

Antimicrobial activity of DV-7751a, a new fluoroquinolone

M. Tanaka, K. Sato, K. Hoshino, 1993, Antimicrobial Agents and Chemotherapy.

Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates

M. Tanaka, K. Sato, K. Hoshino, 1992, Antimicrobial Agents and Chemotherapy.

Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases

K. Akahane, M. Sato, A. Yoshida, 1991, Antimicrobial Agents and Chemotherapy.

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B.

K. Suenaga, H. Kigoshi, O. Ohno, 2015, Organic & biomolecular chemistry.

Total synthesis of (-)-13-oxyingenol and its natural derivative.

H. Kigoshi, Yamato Miyazawa, Takayuki Ohyoshi, 2012, Angewandte Chemie.

Inhibition by quinolones of DNA gyrase from Staphylococcus aureus

T. Nishino, M. Tanaka, K. Sato, 1991, Antimicrobial Agents and Chemotherapy.

Structure and chemistry of kidamycin

Y. Iitaka, G. Ohta, I. Hayakawa, 1975 .

Levofloxacin, a new quinolone antibacterial agent. An introductory overview.

S. Takayama, K. Furuhama, I. Hayakawa, 1992, Arzneimittel-Forschung.

Quantitative analysis of the Tricholoma ustale-derived toxin, ustalic acid, in mushroom and food samples by LC-MS/MS.

N. Yoshioka, Junko Tomozawa, H. Akiyama, 2020, Forensic science international.

Synthesis of ustalic acid, an inhibitor of Na+,K+-ATPase

H. Kigoshi, Hidekazu Watanabe, I. Hayakawa, 2008 .

DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

T. Agatsuma, K. Hagihara, Takehiro Hirai, 2016, Clinical Cancer Research.

A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization

M. Murakami, K. Wakita, T. Agatsuma, 2019, Clinical Cancer Research.

Synthetic studies toward biselides. Part 1: synthesis of the core carbon framework of biselides A, B, and E using Stille coupling

H. Kigoshi, I. Hayakawa, M. Yamaura, 2012 .

Synthesis of Glaziovianin A: A Potent Antitumor Isoflavone

H. Kigoshi, I. Hayakawa, Akiyuki Ikedo, 2007 .

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle

Berati Cerikan, O. Gruss, E. Schiebel, 2015, Nature Communications.

Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its O7-Propargyl Analogue

H. Kigoshi, I. Hayakawa, Akiyuki Ikedo, 2014 .

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.

T. Usui, H. Kigoshi, Takumi Chinen, 2012, Bioorganic & medicinal chemistry.

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.

T. Usui, H. Osada, Sayaka Kazami, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Glaziovianin A: A Potent Antitumor Isoflavone.

H. Kigoshi, I. Hayakawa, Akiyuki Ikedo, 2008 .

DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models

T. Agatsuma, T. Maejima, T. Shibutani, 2022, Molecular cancer therapeutics.

Synthetic studies toward biselides. Part 2: synthesis of the macrolactone part of biselides A and B using allylic oxidation

Yu Onozaki, H. Kigoshi, Takuya Yamada, 2012 .

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

M. Sodeoka, Y. Tamura, Go Hirai, 2016, Organic & biomolecular chemistry.

Structure of zamamistatin-a correction

Y. Tsunematsu, M. Kita, H. Kigoshi, 2008 .

Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death

T. Usui, A. Sakakura, H. Kigoshi, 2021, Frontiers in Pharmacology.

Aldol-type reaction of a 4-pyrone: a straightforward approach to 4-pyrone-containing natural products

T. Sengoku, H. Kigoshi, I. Hayakawa, 2009 .

Aldol-Type Reaction of a 4-Pyrone: A Straightforward Approach to 4-Pyrone-Containing Natural Products.

T. Sengoku, H. Kigoshi, I. Hayakawa, 2009 .

Enantioselective Diels–Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts

A. Sakakura, Y. Araki, T. Kudoh, 2020, Synlett.

A Library Synthesis of 4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Antitumor Agents.

T. Agatsuma, H. Furukawa, S. Naruto, 2004 .

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling.

Yuta Suzuki, M. Ueda, H. Kigoshi, 2008, Organic letters.