Dong Guo

发表

Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.

Peng-Cheng Wang, Kequan Fu, Junqi Wang, 2022, Journal of medicinal chemistry.

PF‐06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity

Kequan Fu, Junqi Wang, Hao-Nan Yuan, 2022, FEBS open bio.

Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease.

Ying Sun, Peng-Cheng Wang, Jianjun Cheng, 2022, Journal of medicinal chemistry.

Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2022, Journal of medicinal chemistry.

Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease.

Ying Sun, Yuyang Xie, Xiangjian Zheng, 2023, Journal of hepatology.

Dicarboxylation of Alkenes with CO2 and Formate via Photoredox Catalysis

Hui Xu, Pei Xu, Dong Guo, 2023, ACS Catalysis.

Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.

Wenchao Zhao, Junqi Wang, Kequan Fu, 2022, Biochemical pharmacology.

Defluorinative Alkylation of Trifluoromethylbenzimidazoles Enabled by Spin-Center Shift: A Synergistic Photocatalysis/Thiol Catalysis Process with CO2•.

Zhijuan Wang, Yu-Chao Yuan, Xudong Cao, 2022, Organic letters.

2,6-diazaspiro[3.4]octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance.

Huanyu Xu, Yinli Qiu, Kequan Fu, 2023, European journal of medicinal chemistry.

mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1

Zhanjun Jia, Hongxing Zhang, Tian Teng, 2022, Nature Metabolism.

Structure-Affinity and Structure-Kinetic Relationship Studies of Benzodiazepine Derivatives for the Development of Efficacious Vasopressin V2 Receptor Antagonists.

Peng-Cheng Wang, Kequan Fu, Xudong Cao, 2023, Journal of medicinal chemistry.

Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V2 Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD.

Jianjun Cheng, Wenzhong Yan, Xiaoke Gu, 2022, Journal of medicinal chemistry.

Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.

Cheng-ying Xie, Wenwen Duan, Jianjun Cheng, 2023, Journal of medicinal chemistry.

Inhibition of mPGES‐2 ameliorates NASH by activating NR1D1 via heme

Zhanjun Jia, Hongxing Zhang, Shanshan Li, 2022, Hepatology.

Target immobilization on glass microfiber membranes as a label-free strategy for hit identification

Dong Guo, Yinan Wang, Yan He, 2023, Analytical and Bioanalytical Chemistry.

Notch3 as a novel therapeutic target for the treatment of ADPKD by regulating cell proliferation and renal cyst development

Kequan Fu, Dong Guo, L. Su, 2024, Biochemical Pharmacology.

A Novel Bifunctional μOR Agonist and σ1R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects.

Bowen Ke, Ting Kang, Yu Gan, 2023, Journal of medicinal chemistry.