F. Jeppsson

发表

Discovery of AZD3839, a potent and selective BACE1 clinical candidate for the treatment of Alzheimer’s Disease*

B. Ploeger, S. Eketjäll, B. Swahn, 2012 .

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease*

Britt-Marie Swahn, Bart Ploeger, Tjerk Bueters, 2012, The Journal of Biological Chemistry.

New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.

S. Eketjäll, B. Swahn, K. Kolmodin, 2012, Journal of medicinal chemistry.

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Richard Svensson, Robert Gustafsson, Hanna Axelsson, 2014, Nature.

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

M. Beato, T. Helleday, E. Homan, 2018, Nature Communications.

Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors

F. Jeppsson, 2016 .

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

S. Haeberlein, S. Eketjäll, J. Janson, 2016, Journal of Alzheimer's disease : JAD.

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

K. Blennow, M. Mercken, H. Zetterberg, 2012, PloS one.

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

L. Meijer, P. Artursson, E. Crespan, 2016, Journal of medicinal chemistry.

Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand

Lars Farde, Britt-Marie Swahn, Johan Sandell, 2010, Journal of neurochemistry.

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

S. Eketjäll, B. Swahn, K. Kolmodin, 2013, The Journal of Neuroscience.

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

Christer Halldin, Lars Farde, Katarina Varnäs, 2013, European Journal of Nuclear Medicine and Molecular Imaging.

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques.

J. Sandell, P. Johnström, A. Juréus, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques.

J. Sandell, J. Malmström, A. Juréus, 2010, Bioorganic & medicinal chemistry letters.

AZD2184: a radioligand for sensitive detection of β‐amyloid deposits

Lars Farde, Johan Sandell, David Wensbo, 2009, Journal of neurochemistry.

Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig

S. Visser, S. Eketjäll, J. Janson, 2014, Pharmaceutical Research.

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Britt-Marie Swahn, Johan Lindström, Stefan Berg, 2012, Journal of medicinal chemistry.

Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity.

J. Malmström, P. Johansson, A. Kers, 2013, Journal of medicinal chemistry.

New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.

S. Eketjäll, B. Swahn, K. Strömberg, 2012 .

Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

P. Artursson, E. Homan, T. Lundbäck, 2017, Nature.

Mth1 Inhibition Eradicates Cancer by Preventing Sanitation of the Dntp Pool Macmillan Publishers Limited. All Rights Reserved ©2014

T. Helleday, E. Homan, T. Lundbäck, 2022 .