Yi Li

发表

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.

I. Pinchuk, A. Brasier, B. Tian, 2021, Inflammatory bowel diseases.

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Shwu‐Yuan Wu, C. Chiang, A. Brasier, 2022, Journal of medicinal chemistry.

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffolding Hopping, Optimization and Pharmacological Evaluation.

A. Brasier, B. Tian, P. Leonard, 2020, Journal of medicinal chemistry.

Chemically targeting the redox switch in AP1 transcription factor ΔFOSB

S. Haggarty, E. Nestler, Wen-Ning Zhao, 2022, Nucleic acids research.

Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus

Dianhua Qiao, A. Brasier, Jia Zhou, 2021, Frontiers in Molecular Biosciences.

Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing

A. Brasier, Ying Ge, David S. Roberts, 2023, bioRxiv.

Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer

Rong Liu, Ceshi Chen, Jia Zhou, 2021, Cell Death & Differentiation.

Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry

A. Brasier, Ying Ge, David S. Roberts, 2021, Viruses.

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis

A. Brasier, N. Sandbo, Jia Zhou, 2022, Frontiers in Molecular Medicine.

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

G. Rudenko, Zhiqing Liu, Haiying Chen, 2020, Bioorganic & medicinal chemistry letters.

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

A. Brasier, David S. Roberts, Xiaofan Xu, 2023, Frontiers in Immunology.