K. Otsuki

发表

Efficacy and immunomodulatory actions of ONO‐4641, a novel selective agonist for sphingosine 1‐phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

M. Imai, S. Nakade, K. Sato, 2013, Clinical and experimental immunology.

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.

T. Kondo, S. Nakade, H. Habashita, 2017, Journal of medicinal chemistry.

Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.

N. Fujii, H. Ohno, I. Nakanishi, 2017, Bioorganic & medicinal chemistry.

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.

K. Shinozaki, T. Matsushita, A. Naganawa, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.

K. Shinozaki, T. Matsushita, A. Naganawa, 2015, Bioorganic & medicinal chemistry letters.

Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.

K. Shinozaki, T. Matsushita, T. Kanaji, 2015, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.

M. Minami, S. Nakade, H. Habashita, 2012, Bioorganic & medicinal chemistry letters.

Discovery of S1P agonists with a dihydronaphthalene scaffold.

M. Minami, S. Nakade, H. Habashita, 2011, Bioorganic & medicinal chemistry letters.

"Catalyst analogue": a concept for constructing multicomponent asymmetric catalysts (MAC) by using a polymer support.

T. Arai, S. Takizawa, H. Sasai, 2003, Angewandte Chemie.

Evidence supporting the activity of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentafuranosylcytosine as a terminator in enzymatic DNA-chain elongation.

A. Matsuda, Y. Hayakawa, R. Kawai, 1998, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.

M. Minami, S. Nakade, H. Habashita, 2011, Bioorganic & medicinal chemistry letters.

Efficacy and immunomodulatory actions of ONO‐4641, a novel selective agonist for sphingosine 1‐phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

S. Nakade, K. Sato, H. Habashita, 2013, Clinical and experimental immunology.