Jonathan V. Pascale

Unraveling the role of 12- and 20-HETE in cardiac pathophysiology: G-protein coupled receptors, pharmacological inhibitors and transgenic approaches.

V. Garcia, P. Lucchesi, Jonathan V. Pascale, 2021, Journal of cardiovascular pharmacology.

Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.

A. Nasjletti, V. Garcia, Sharath Kandhi, 2020, American journal of physiology. Regulatory, integrative and comparative physiology.

20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance.

J. Falck, M. Schwartzman, V. Garcia, 2020, Prostaglandins & other lipid mediators.

Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase

S. Gupte, J. Falck, M. Schwartzman, 2022, Journal of hypertension.

Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

R. Collins, J. Marchini, G. Abecasis, 2021, Science.

Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75

J. Falck, M. Schwartzman, V. Garcia, 2021, British journal of pharmacology.

Gpr75‐deficient mice are protected from high‐fat diet–induced obesity

E. Dirice, M. Schwartzman, V. Garcia, 2023, Obesity.

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

W. Sessa, D. Stuehr, B. Isakson, 2020, Proceedings of the National Academy of Sciences.

20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond.

E. Dirice, J. Falck, M. Schwartzman, 2023, Advances in Pharmacology.