D. Rawson

发表

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.

Tanya L Hay, E. Stevens, P. Bungay, 2015, ACS medicinal chemistry letters.

The preparation of enantiomerically enriched γ-amino acids (GABAs) using palladium catalysed allylic substitution

C. J. Martin, Jonathan M. J. Williams, D. Rawson, 1998 .

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.

T. Ryckmans, P. Cox, Linda Kitching, 2011, Bioorganic & medicinal chemistry letters.

The design and synthesis of a novel series of indole derived selective ETA antagonists

K. Dack, K. James, R. Dickinson, 2002 .

A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.

K. Beaumont, N. Mount, David G. Brown, 2006, Journal of medicinal chemistry.

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.

P. A. Bradley, Brian E Marron, Ian K Gurrell, 2017, Journal of medicinal chemistry.

Diastereoselective conversion of sulfides into sulfoxides. 1,5- and 1,6-asymmetric induction

C. J. Martin, J. Bower, A. Slawin, 1996 .

Asymmetric tandem additions to chiral naphthyloxazolines. A new and potent chiral auxiliary resulting in a major improvement in convenience and efficiency

A. Meyers, D. Rawson, 1991 .

Part 2: Design, synthesis and evaluation of hydroxyproline-derived α2δ ligands.

A. Harrison, Paul Turnpenny, G. Maw, 2011, Bioorganic & medicinal chemistry letters.

Studies in macrolide synthesis: A concise asymmetric synthesis of a macrolide intermediate for the erythronolides.

D. Laffan, I. Paterson, D. Rawson, 1988 .

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.

M. Bunnage, K. Beaumont, D. Leahy, 2012, Bioorganic & medicinal chemistry.

Chiral oxazoline route to enantiomerically pure biphenyls: magnesio and copper mediated asymmetric hetero- and homo-coupling reactions

H. Moorlag, A. Meier, A. Meyers, 2004 .

A highly stereoselective synthesis of axially chiral biaryls. Application to the synthesis of a potential chiral catalysts.

A. Meier, A. Meyers, D. Rawson, 1992 .

Diastereoselective Conversion of Sulfides into Sulfoxides. 1,5‐ and 1, 6‐Asymmetric Induction.

C. J. Martin, J. Bower, A. Slawin, 1996 .

Studies in macrolide synthesis: A highly stereoselective synthesis of (+)-(9S)-dihydroerythronolide a using macrocyclic stereocontrol

I. Paterson, D. Rawson, 1989 .

Highly reactive organolithiums (from Freeman's reagent) and their additions to naphthalene oxazolines

A. Meyers, D. Rawson, 1991 .

Isoform-selective voltage-gated Na(+) channel modulators as next-generation analgesics.

S. England, D. Rawson, 2010, Future medicinal chemistry.

Part 1: N-alkylated glycines as potent α2δ ligands.

J. Bryans, D. Blakemore, G. Maw, 2011, Bioorganic & Medicinal Chemistry Letters.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Brian E Marron, Neil A Castle, Rubben Torella, 2017, Bioorganic & medicinal chemistry letters.