D. Dougherty

发表

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

Charlene H. Kim, Amol V. Shivange, J. Marvin, 2021, bioRxiv.

Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.

H. Lester, D. Dougherty, K. N. Daeffler, 2012, Journal of the American Chemical Society.

Cation-p Interactions Involving Aromatic Amino Acids

D. Dougherty, 2007 .

Thinking Outside the Box: Residues that Shape the Agonist Binding Site of Nicotinic Acetylcholine Receptors

H. Lester, Nyssa L. Puskar, D. Dougherty, 2010 .

THEORETICAL STUDIES OF THE SUPRAMOLECULAR SYNTHON BENZENE · · · HEXAFLUOROBENZENE

A. West, S. Mecozzi, D. Dougherty, 1997 .

Phenyl–Perfluorophenyl Stacking Interactions: A New Strategy for Supermolecule Construction

R. Grubbs, A. Dunn, G. Coates, 1997 .

Some applications of the empirical force field method to stereochemistry

K. Mislow, W. D. Hounshell, D. Dougherty, 2010 .

Bond lengthening and through-bond interactions in p,p'-dibenzene and related molecules

H. Schlegel, K. Mislow, D. Dougherty, 1978 .

Allosteric activation of the 5-HT3AB receptor by mCPBG

H. Lester, T. F. Miles, D. Dougherty, 2015, Neuropharmacology.

Biomimetic catalysis of S_N2 reactions through cation-π interactions. The role of polarizability in catalysis

D. Stauffer, D. Dougherty, L. Jimenez, 1992 .

Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression

H. Lester, Brandon J. Henderson, B. Cohen, 2016, PloS one.

The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.

H. Lester, T. F. Miles, D. Dougherty, 2013, Biophysical journal.

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

S. Lummis, D. Dougherty, Richard A Mosesso, 2018, Biochemistry.

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors*

S. Lummis, A. Rocchi, Matthew Rienzo, 2015, The Journal of Biological Chemistry.

Non-Canonical Probes of Proline Residues in GLIC

S. Lummis, A. Rocchi, Matthew Rienzo, 2015 .

A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way.

H. Lester, Kiowa S. Bower, T. F. Miles, 2012, ACS chemical neuroscience.

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function

Kiowa S. Bower, S. Lummis, K. Price, 2008, European journal of pharmacology.

Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing

Shyam M. Saladi, H. Lester, E. Tajkhorshid, 2018, eNeuro.

A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor.

H. Lester, S. Lummis, D. Dougherty, 2005, Chemistry & biology.

Can lone pairs bind to a pi system? The water...hexafluorobenzene interaction.

J. Gallivan, D. Dougherty, 1999, Organic letters.

Biomimetic Catalysis of an SN2 Reaction Resulting from a Novel Form of Transition-State Stabilization†

D. Stauffer, D. Dougherty, R. Barrans, 1990 .

"Hydrophobic" binding of water-soluble guests by high-symmetry, chiral hosts. An electron-rich receptor site with a general affinity for quaternary ammonium compounds and electron-deficient .pi. systems

T. Shepodd, M. Petti, D. Dougherty, 1988 .

Molecular recognition in aqueous media: donor-acceptor and ion-dipole interactions produce tight binding for highly soluble guests

T. Shepodd, M. Petti, D. Dougherty, 1988 .

Tight, oriented binding of an aliphatic guest by a new class of water-soluble molecules with hydrophobic binding sites.

T. Shepodd, M. Petti, D. Dougherty, 1986, Journal of the American Chemical Society.

A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation.

N. Davidson, S. Silverman, P. Kofuji, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of a new class of hydrophobic binding sites

T. Shepodd, M. Petti, D. Dougherty, 1986 .

Molecular recognition in aqueous media. New binding studies provide further insights into the cation-π interaction and related phenomena

J. Forman, L. Mizoue, P. Kearney, 1993 .

Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

H. Lester, Michael R. Post, Gabrielle S. Tender, 2017, eNeuro.

GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

S. Lummis, Federico Comitani, Jamie Ashby, 2012, Biophysical journal.

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Charlene H. Kim, J. Marvin, L. Looger, 2022, bioRxiv.

Ketamine inside neurons?

H. Lester, L. Lavis, D. Dougherty, 2015, The American journal of psychiatry.

New insights into the therapeutic inhibition of voltage-gated sodium channels

R. Horn, C. Ahern, Amy L. Eastwood, 2008, Channels.

Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

Charlene H. Kim, J. Marvin, L. Looger, 2022, The Journal of Neuroscience.

Novel magnetic properties of a doped organic polymer. A possible prototype for a polaronic ferromagnet

Wonghil Chang, D. Dougherty, D. A. Kaisaki, 1991 .

Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor.

H. Lester, T. Gallagher, Hugo Rego Campello, 2022, Journal of the American Chemical Society.

Caging proteins through unnatural amino acid mutagenesis.

H. Lester, E. Petersson, N. Zacharias, 2003, Methods in enzymology.

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: evaluating suppression efficiency.

Erik A. Rodriguez, H. Lester, D. Dougherty, 2007, RNA.

Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors.

H. Lester, Michael R. Post, D. Dougherty, 2017, Biochemistry.

Strained rings as a source of unsaturation: polybenzvalene, a new soluble polyacetylene precursor

R. Grubbs, T. Swager, D. Dougherty, 1988 .

Key binding interactions for memantine in the NMDA receptor.

H. Lester, E. Branigan, Wesley Y Yu, 2013, ACS chemical neuroscience.

Concerning the thermodynamics of molecular recognition in aqueous and organic media. Evidence for significant heat capacity effects

D. Stauffer, D. Dougherty, R. Barrans, 1990 .

Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor

H. Lester, Crystal N. Dilworth, D. Dougherty, 2014, Neuropharmacology.

Caged phosphoproteins.

B. Imperiali, M. Vázquez, E. Petersson, 2005, Journal of the American Chemical Society.

MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production.

H. Lester, E. Petersson, M. Shahgholi, 2002, RNA.

Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97.

H. Lester, S. Lummis, Claire L. Padgett, 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Theoretical studies of the singlet and triplet potential energy surfaces of cyclobutanediyl

J. Pranata, D. Dougherty, 1989 .

Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT3 and nACh Receptors.

S. Lummis, D. Dougherty, Richard A Mosesso, 2019, ACS chemical neuroscience.

Synthesis and properties of diethyl 5,10-dihetera-5,10-dihydroindeno[2,1-a]indene-2,7-dicarboxylates

P. Kaszyński, D. Dougherty, 1993 .

An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.

H. Lester, D. Dougherty, C. B. Marotta, 2015, Chemistry & biology.

Approaches to Magnetic Organic Materials

R. Grubbs, R. Jain, P. Ho, 1991 .

Matrix Isolation EPR Spectroscopy of Biradicals

D. Dougherty, 1990 .

New designs for organic molecules and materials with novel magnetic properties

D. Dougherty, D. A. Kaisaki, 1990 .

New Designs for Very High Spin Hydrocarbons

D. Dougherty, 1989 .

Non-kekulé molecules derived conceptually by heteroatom-for-carbon substitution in alternant hydrocarbons: M-Quinomethane and M-Naphthoquinomethane

D. Seeger, J. A. Berson, A. Matlin, 1982 .

New Organic Polymers And Molecules With Very High Spin States

A. West, S. Silverman, S. Jacobs, 1993 .

2,4-Dimethylene-1,3-cyclobutanediyl, the non-Kekule isomer of benzene. Synthesis, EPR, and electronic spectroscopy

D. Dougherty, G. Snyder, 1989 .

Non-Kekule acenes. The dimethylenepolycyclobutadienes, a new class of (4n + 2) alternant hydrocarbons

J. Pranata, D. Dougherty, 1987 .

Spin Control in Organic Molecules

D. Dougherty, 1991 .

Concerning the relevance of ethane conformational analysis to acyclic aldol transition states

D. Dougherty, 1982 .

A computational study of nicotine conformations in the gas phase and in water.

D. Dougherty, D. Elmore, 2000, The Journal of organic chemistry.

Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor.

H. Lester, T. Gallagher, H. Campello, 2019, Journal of the American Chemical Society.

A Computational Study of Cation−π Interactions vs Salt Bridges in Aqueous Media: Implications for Protein Engineering

J. Gallivan, Dennis A. Dougherty, Justin P. Gallivan, 2000 .

Evaluation of potential ferromagnetic coupling units: the bis(TMM) [bis(trimethylenemethane)] approach to high-spin organic molecules

R. Jain, S. Jacobs, D. Shultz, 1993 .

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

D. A. Dougherty, D. Dougherty, 1996, Science.

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

H. Lester, A. Goate, Jen C. Wang, 2009, The AAPS Journal.

Modern Physical Organic Chemistry

Eric V. Anslyn, D. A. Dougherty, E. Anslyn, 2005 .

Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates.

D. Dougherty, Sean M. A. Kedrowski, 2010, Organic letters.

Combination of Superexchange and Spin-Polarization Mechanisms Leads to a Novel Hydrocarbon Tetraradical with a High-Spin Ground State†

S. Jacobs, D. Dougherty, 1994 .

Cation-π interactions in structural biology

D. A. Dougherty, J. Gallivan, D. Dougherty, 1999 .

Unnatural amino acids as probes of protein structure and function.

D. A. Dougherty, D A Dougherty, D. Dougherty, 2000, Current opinion in chemical biology.

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids

H. Lester, Kiowa S. Bower, D. Dougherty, 2009, Proceedings of the National Academy of Sciences.

A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor.

H. Lester, Ariele P. Hanek, D. Dougherty, 2008, Journal of the American Chemical Society.

The Cationminus signpi Interaction.

D. A. Dougherty, J. C. Ma, D. Dougherty, 1997, Chemical reviews.

Conformational analysis of tetraarylethanes

K. Mislow, J. Blount, D. Dougherty, 1978 .

Cyclobutanediyls: a new class of localized biradicals. Synthesis and EPR spectroscopy

R. Jain, M. Sponsler, F. Coms, 1988 .

2,3-Diazabicyclo[2.1.1]hex-2-ene. Synthesis and thermal decomposition

D. Dougherty, M. Chang, 1981 .

1,3-Diphenyl-1,3-cyclopentanediyl: A remarkably stable localized biradical

F. Coms, D. Dougherty, 1988 .

CIRCULAR DICHROISM STUDIES OF MOLECULAR RECOGNITION WITH CYCLOPHANE HOSTS IN AQUEOUS MEDIA

J. Forman, D. Dougherty, R. Barrans, 1995 .

Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys Loop Receptors*

H. Lester, W. Limapichat, D. Dougherty, 2010, The Journal of Biological Chemistry.

Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process.

D. A. Dougherty, C. Regan, David P. Walton, 2017, Journal of the American Chemical Society.

BICYCLO(1.1.1)PENTANONE. SYNTHESIS, THERMAL CHEMISTRY, AND PHOTOCHEMISTRY

M. Sponsler, D. Dougherty, 1985 .

An improved method for determining bimolecular association constants from NMR titration experiments

D. Dougherty, R. Barrans, 1994 .

The cation-π interaction.

D. Dougherty, 2013, Accounts of chemical research.

Unnatural amino acid mutagenesis in mapping ion channel function

H. Lester, D. Dougherty, D. Beene, 2003, Current Opinion in Neurobiology.

Mapping disulfide connectivity using backbone ester hydrolysis.

H. Lester, P. England, D. Dougherty, 1999, Biochemistry.

Multiple Tyrosine Residues Contribute to GABA Binding in the GABAC Receptor Binding Pocket

S. Lummis, Jamie Ashby, D. Dougherty, 2011, ACS chemical neuroscience.

Concerning the Effects of Aromatic Ring Fluorination on the Cation−π Interaction and Other Molecular Recognition Phenomena in Aqueous Media

D. Dougherty, Sarah M. Ngola and, 1998 .

The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor.

H. Lester, C. Gibbs, W. Zhong, 2001, Chemistry & biology.

INCORPORATION OF ESTERS INTO PROTEINS : IMPROVED SYNTHESIS OF HYDROXYACYL TRNAS

H. Lester, P. England, D. Dougherty, 1999 .

In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system.

H. Lester, J. Gallivan, S. Silverman, 1998, Methods in enzymology.

Site-specific, photochemical proteolysis applied to ion channels in vivo.

D. A. Dougherty, H. Lester, N. Davidson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A Selective Receptor for Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt Bridges That Are Highly Exposed to Water

P. Kearney, S. Mecozzi, S. Ngola, 1999 .

A mechanism for ion selectivity in potassium channels: computational studies of cation-pi interactions.

D A Dougherty, R A Kumpf, R. Kumpf, 1993, Science.

Evidence for the Importance of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors.

S. Ngola, D. Dougherty, 1996, The Journal of organic chemistry.

Ion-dipole effect as a force for molecular recognition in organic media

D. Stauffer, D. Dougherty, 1988 .

The Crystal Structure of a Potassium Channel- A New Era in the Chemistry of Biological Signaling.

H. Lester, D. Dougherty, 1998, Angewandte Chemie.

Long bonds and through-bond coupling

H. Schlegel, K. Mislow, W. D. Hounshell, 1976 .

Direct, ESR observation of the localized biradical 1,3-dimethyl-1,3-cyclobutadiyl

R. Jain, D. Dougherty, G. Snyder, 1984 .

Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel Implications for the Mechanism of Gating

H. Lester, P. England, Yinong Zhang, 1999, Cell.

A combination of empirical force field and extended Hueckel molecular orbital calculations as a computational approach to conformational analysis

K. Mislow, D. Dougherty, 1979 .

Attempted Synthesis of a Stable, Quintet, Tetraphenoxyl Tetraradical: Facile Rearrangement of a Substituted Bicyclobutane

D. Dougherty, A. Shultz, Kraig K. Anderson, 1997 .

M-QUINOMETHANE: SYNTHESIS OF A COVALENT-BIRADICALOID PAIR OF VALENCE TAUTOMERS

J. A. Berson, A. Matlin, E. F. Hilinski, 1979 .

Cation−π Interactions in Simple Aromatics: Electrostatics Provide a Predictive Tool

Sandro Mecozzi, Dennis A. Dougherty, and Anthony P. West, 1996 .

Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

D. A. Dougherty, H. Lester, Ting-Wei Mu, 2003, Journal of the American Chemical Society.

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine.

Niki M Zacharias, Gabriel S Brandt, H. Lester, 2002, Biochemistry.

Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response

H. Lester, Christopher I. Richards, R. Pantoja, 2012, Molecular Pharmacology.

Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor.

H. Lester, Nyssa L. Puskar, D. Dougherty, 2012, ACS chemical biology.

Cation-pi interactions in structural biology.

D. A. Dougherty, J. Gallivan, D. Dougherty, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Nicotinic Acetylcholine Receptor Subtypes Dorsal Root Ganglion Neurons Express Multiple

Loren J. Martin, H. Lester, J. Changeux, 2015 .

Nicotine Binding to Brain Receptors Requires a Strong Cation-π Interaction

Henry A. Lester, H. Lester, Nyssa L. Puskar, 2009, Nature.

Do High-Spin Topology Rules Apply to Charged Polyradicals? Theoretical and Experimental Evaluation of Pyridiniums as Magnetic Coupling Units

A. West, S. Silverman, D. Dougherty, 1996 .

Cation-pi interactions in ligand recognition and catalysis.

Dennis A Dougherty, N. Zacharias, Niki Zacharias, 2002, Trends in pharmacological sciences.

Do High-Spin Topology Rules Apply to Charged Polyradicals? Theoretical and Experimental Evaluation of Pyridiniums as Magnetic Coupling Units.

A. West, S. Silverman, D. Dougherty, 2010 .

Organic Cations in Molecular Recognition and Molecular Magnetism

A. West, S. Silverman, S. Mecozzi, 1996 .

PROTOTYPES FOR THE POLARONIC FERROMAGNET. SYNTHESIS AND CHARACTERIZATION OF HIGH-SPIN ORGANIC POLYMERS

P. Kaszyński, Michael M. Murray, Wonghil Chang, 1994 .

Diphenylbicyclo[2.1.0]pentane. A persistent hydrocarbon with a very weak carbon-carbon bond

F. Coms, D. Dougherty, 1989 .

Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel

D. A. Dougherty, H. Lester, A. Karschin, 2001, The Journal of general physiology.

3,4-Diazabenzvalene, the azoalkane precursor to tetrahedrane. Synthesis and reactivity.

D. Dougherty, D. A. Kaisaki, 1988 .

2,4-Dimethylene-1,3-cyclobutadiyl

D. Dougherty, G. Snyder, 1985 .

Chemical activation as a probe of reaction mechanism. Synthesis and thermal decomposition of 2,3-diazabicyclo[2.1.1]hex-2-enes

R. Jain, D. Dougherty, M. Chang, 1984 .

Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide.

D A Dougherty, A. West, S. Mecozzi, 1996, Proceedings of the National Academy of Sciences of the United States of America.

CHEMICAL ACTIVATION AS A PROBE OF REACTION MECHANISM. SYNTHESIS AND THERMAL DECOMPOSITION OF 2,3‐DIAZABICYCLO(2.1.1)HEX‐2‐ENES

R. Jain, D. Dougherty, M. Chang, 1984 .

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor.

D. A. Dougherty, D A Dougherty, H. Lester, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

Henry A. Lester, Sarah C. R. Lummis, H. Lester, 2005, Nature.

Cys-loop neuroreceptors: structure to the rescue?

Dennis A Dougherty, D. Dougherty, 2008, Chemical reviews.

Cation-pi interactions involving aromatic amino acids.

D. Dougherty, 2007, The Journal of nutrition.

Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor.

D. A. Dougherty, S. Reisman, Justin Y Su, 2020, ACS medicinal chemistry letters.

Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis.

G. Kochendoerfer, H. Lester, D. Clayton, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The 5-HT 3 AB Receptor Shows an A 3 B 2 Stoichiometry at the Plasma Membrane

H. Lester, D. Dougherty, T. Miles, 2013 .

Long-range coupling in an allosteric receptor revealed by mutant cycle analysis.

H. Lester, Jai A. P. Shanata, Shawnalea J. Frazier, 2009, Biophysical journal.

Probing the role of a conserved M1 proline residue in 5-hydroxytryptamine(3) receptor gating.

H. Lester, P. England, H. Dang, 2000, Molecular pharmacology.

Chapter 4: Longrange Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis Reproduced with Permission From

H. Lester, Biophys, Jai A. P. Shanata, 2022 .

Flash Decaging of Tyrosine Sidechains in an Ion Channel

Henry A. Lester, Scott K. Silverman, H. Lester, 1998, Neuron.

Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins.

D A Dougherty, H. Lester, J. Gallivan, 1997, Chemistry & biology.

A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT3 Receptor

H. Lester, Kiowa S. Bower, A. J. Thompson, 2008, Biochemistry.

Cys-loop receptors: new twists and turns

Henry A. Lester, D. A. Dougherty, H. Lester, 2004, Trends in Neurosciences.

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

Loren J. Martin, H. Lester, J. Changeux, 2015, Science Translational Medicine.

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.

D. A. Dougherty, H. Lester, E. Petersson, 2005, Journal of the American Chemical Society.

A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block*

R. Horn, C. Ahern, Amy L. Eastwood, 2007, Journal of Biological Chemistry.

Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs.

S. Lummis, Matthew Rienzo, D. Dougherty, 2014, Chemistry & biology.

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels

R. Horn, C. Ahern, Amy L. Eastwood, 2008, Circulation research.

Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors

H. Lester, W. Limapichat, Michael R. Post, 2015, Neuropharmacology.

Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors

H. Lester, W. Limapichat, D. Dougherty, 2014, Molecular Pharmacology.

Subtype-Specific Mechanisms for Functional Interaction between a 6 b 4 * Nicotinic Acetylcholine Receptors and P 2 X Receptors s

H. Lester, W. Limapichat, D. Dougherty, 2014 .

In Vivo Incorporation of Non‐canonical Amino Acids by Using the Chemical Aminoacylation Strategy: A Broadly Applicable Mechanistic Tool

Ethan B. Van Arnam, D. Dougherty, 2014, Chembiochem : a European journal of chemical biology.

In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression.

Erik A. Rodriguez, H. Lester, D. Dougherty, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Probing the Role of Backbone Hydrogen Bonding in a Critical β Sheet of the Extracellular Domain of a Cys‐Loop Receptor

H. Lester, D. Dougherty, K. Gleitsman, 2009, Chembiochem : a European journal of chemical biology.

Effects of through-bond and through-space interactions on singlet-triplet energy gaps in localized biradicals

D. Dougherty, A. Goldberg, 1983 .

Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor

H. Lester, Angela P. Blum, D. Dougherty, 2011, The Journal of Biological Chemistry.

A Gating Charge Transfer Center in Voltage Sensors

Xiao Tao, Roderick MacKinnon, R. MacKinnon, 2010, Science.

A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock.

David P. Walton, D. Dougherty, 2017, Journal of the American Chemical Society.

Charge-transfer heptamethine dyes for NIR singlet oxygen generation.

D. Dougherty, J. Jarman, 2019, Chemical communications.

A general strategy for visible-light decaging based on the quinone cis-alkenyl lock.

David P. Walton, D. Dougherty, 2019, Chemical communications.

Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.

Jonas Korlach, Rahul Srinivasan, Khai Luong, 2012, Nano letters.

Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region.

H. Lester, J. A. Maurer, D. Dougherty, 2000, The Journal of biological chemistry.

Cation-p Interactions Involving Aromatic Amino Acids 1 – 4

D. Dougherty, 2007 .

Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor.

H. Lester, J. Gallivan, G. Brandt, 2001, American journal of physiology. Cell physiology.

Experimental and Computational Studies of Cation-π Interactions in Natural and Synthetic Receptors. Benzene as a Pseudoanion

J. Forman, L. Mizoue, P. Kearney, 1994 .

A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors*

H. Lester, Ariele P. Hanek, D. Dougherty, 2005, Journal of Biological Chemistry.

Investigating the Binding Interactions of NS6740, a Silent Agonist of the Nicotinic Receptor.

C. E. Blunt, D. Dougherty, 2019, Molecular pharmacology.

Expression and Circular Dichroism Studies of the Extracellular Domain of the α Subunit of the Nicotinic Acetylcholine Receptor*

H. Lester, A. West, P. Bjorkman, 1997, The Journal of Biological Chemistry.

A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site

Francisco Bezanilla, Henry A. Lester, Baron Chanda, 2004 .

Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide.

D. A. Dougherty, H. Lester, J. Leite, 2003, Rapid communications in mass spectrometry : RCM.

Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients

H. Lester, B. Ritz, R. Alvarez, 2020, Qeios.

Reconstitution of ion channels in agarose-supported silicon orifices.

Jay L Nadeau, Victor E White, J. Nadeau, 2007, Biosensors & bioelectronics.

Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations.

Donald E Elmore, Dennis A Dougherty, D. Dougherty, 2003, Biophysical journal.

A high-throughput screen for MscL channel activity and mutational phenotyping.

J. A. Maurer, D. Dougherty, 2001, Biochimica et biophysica acta.

Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel.

D. Dougherty, D. Elmore, 2001, Biophysical journal.

Comparing and Contrasting Escherichia coliand Mycobacterium tuberculosis Mechanosensitive Channels (MscL)

H. Lester, J. A. Maurer, D. Dougherty, 2000, The Journal of Biological Chemistry.

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site.

H. Lester, F. Bezanilla, V. Auyeung, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The cation-π interaction: From structural biology to neuroreceptor binding sites

D. Dougherty, 2002 .

Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl

H. Lester, D. Dougherty, K. N. Daeffler, 2014, ACS chemical biology.

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

S. L. Mayo, H. Lester, R. Howard, 2023, bioRxiv.

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Charlene H. Kim, J. Marvin, L. Looger, 2022, bioRxiv.

Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Charlene H. Kim, Amol V. Shivange, J. Marvin, 2019, The Journal of general physiology.

Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β2Tyr97

D. A. Dougherty, H. Lester, S. Lummis, 2007, The Journal of Neuroscience.

Pos Cell-based Single-molecule Detection of a Fluorescent Unnatural Amino Acid Incorporated into the Nicotinic Receptor

Erik A. Rodriguez, H. Lester, R. Iino, 2008 .

Photoactivation of an Acid‐Sensitive Ion Channel Associated with Vision and Pain

H. Gray, J. Winkler, O. S. Shafaat, 2016, ChemBioChem.

Structure of hexaphenylethane and congeners as determined by empirical force field calculations

K. Mislow, W. D. Hounshell, D. Dougherty, 1977 .

Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis.

H. Lester, N. Duffy, D. Dougherty, 2012, ACS chemical biology.

Bicyclo[1.1.1]pentanone. Synthesis, thermal chemistry, and photochemistry

M. Sponsler, D. Dougherty, 1984 .

Functional Probes of Drug–Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground

Ethan B. Van Arnam, D. Dougherty, 2014, Journal of medicinal chemistry.

A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists

H. Lester, S. Lummis, J. Lynch, 2011, Molecular Pharmacology.

A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue

H. Lester, S. Lummis, J. Lynch, 2008, The Journal of Neuroscience.

Calcium block of single sodium channels: role of a pore-lining aromatic residue.

R. Horn, C. Ahern, Amy L. Eastwood, 2007, Biophysical journal.

β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats

H. Lester, Sara R. Jones, Melissa A. Tapia, 2023, eNeuro.

An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline

D. A. Dougherty, H. Lester, Ethan B. Van Arnam, 2013, Molecular Pharmacology.

Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.

H. Lester, Nyssa L. Puskar, Jai A. P. Shanata, 2012, Journal of the American Chemical Society.

Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors.

Erik A. Rodriguez, H. Lester, R. Pantoja, 2009, Biophysical journal.

A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding.

H. Lester, D. Dahan, E. Petersson, 2002, Journal of the American Chemical Society.

Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors

H. Lester, I. Rreza, D. Dougherty, 2014, ACS chemical biology.

Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells.

H. Lester, D. Dougherty, S. Monahan, 2003, Chemistry & biology.

In Vivo Studies of Receptors and Ion Channels with Unnatural Amino Acids

D. Dougherty, 2009 .

An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels

Richard Horn, Christopher A. Ahern, R. Horn, 2009, The Journal of general physiology.

Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation.

Erik A. Rodriguez, H. Lester, D. Dougherty, 2007, RNA.

An Engineered Tetrahymena tRNAGln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression*

H. Lester, F. Du, J. Sampson, 1996, The Journal of Biological Chemistry.

Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2

H. Lester, Christopher I. Richards, R. Srinivasan, 2012, International journal of molecular sciences.

Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis.

H. Lester, E. Petersson, D. Dougherty, 2006, ACS chemical biology.

Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues

S. Lummis, D. Dougherty, 2022, Membranes.

Proline Residues Contribute to Efficient GABAp Receptor Function.

S. Lummis, D. Dougherty, B. W. Baker, 2020, ACS chemical neuroscience.

Generation and Evaluation of a Large Mutational Library from the Escherichia coli Mechanosensitive Channel of Large Conductance, MscL

J. A. Maurer, D. Dougherty, 2003, Journal of Biological Chemistry.

A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors

D. Dougherty, Richard Mosesso, 2018, The Journal of Biological Chemistry.

Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes*

H. Lester, Nyssa L. Puskar, D. Dougherty, 2011, The Journal of Biological Chemistry.

Confirming the revised C-terminal domain of the MscL crystal structure.

H. Lester, D. Clayton, J. A. Maurer, 2008, Biophysical journal.

Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance.

Steven A. Spronk, D. Dougherty, D. Elmore, 2006, Biophysical journal.

Ferromagnetic and high spin molecular based materials in Dallas

D. Dougherty, Joel S A Miller, 1989 .

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

D. Bertrand, I. D. de Esch, P. Corringer, 2012, Proceedings of the National Academy of Sciences.

Binding Interactions with the Complementary Subunit of Nicotinic Receptors*

H. Lester, Angela P. Blum, Ethan B. Van Arnam, 2013, The Journal of Biological Chemistry.

Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

Henry A. Lester, H. Lester, Dennis A. Dougherty, 2010, Proceedings of the National Academy of Sciences.

An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor That Contributes to Channel Gating*

H. Lester, D. Dougherty, Sean M. A. Kedrowski, 2008, Journal of Biological Chemistry.

Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor.

H. Lester, A. Cashin, D. Dougherty, 2007, Biochemistry.

Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel.

H. Lester, S. Silverman, D. Dougherty, 1998, Biophysical journal.

A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels

H. Lester, R. Horn, C. Ahern, 2006, The Journal of general physiology.

Cation-π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation.

D. Dougherty, M. Davis, 2015, Physical chemistry chemical physics : PCCP.

Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor

S. Lummis, Jamie Ashby, D. Dougherty, 2011, The Journal of Neuroscience.

Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K+ Channel*

H. Lester, S. Silverman, D. Dougherty, 1996, The Journal of Biological Chemistry.

Effects of substituents on the length of central C(sp3)–C(sp3) bond in anthracene photodimers and related molecules

D. A. Dougherty, G. Kaupp, E. Ōsawa, 1986 .

Concerning the viability of 1,4,6,9-spiro[4.4]nonatetrayl as a reactive intermediate. New biradical-to-biradical rearrangements

L. McElwee‐White, D. Dougherty, 1984 .

Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position

H. Lester, W. Zhong, P. Kearney, 1996, Neuron.

Flash Decaging of Tyrosine Neurotechnique Sidechains in an Ion Channel

H. Lester, Jeffrey C. Miller, S. Silverman, 1998 .

Conformational effects on high-spin organic molecules

S. Silverman, D. Dougherty, 1993 .

Cyclophane Hosts: Binding of Lipophilic and Cationic Guests

D. Dougherty, 1997 .

On the role of Newman projections in conformational analysis. Evidence for nonalternating ground states in highly strained molecules

K. Mislow, W. D. Hounshell, D. Dougherty, 1978 .

Establishing an Ion Pair Interaction in the Homomeric ρ1 γ-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway*

H. Lester, D. Dougherty, Jinti Wang, 2007, Journal of Biological Chemistry.

Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.

H. Lester, Ethan B. Van Arnam, D. Dougherty, 2011, ACS chemical biology.

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

S. L. Mayo, H. Lester, R. Howard, 2023, bioRxiv.

Stereochemical issues in studies of ion channel proteins.

D. Dougherty, 1998, Chirality.

Cyclobutane as a general ferromagnetic coupling unit. Design and synthesis of a new, hydrocarbon quintet

R. Jain, D. Dougherty, J. Novak, 1989 .

New Views of Multi-Ion Channels

H. Lester, D. Dougherty, 1998, The Journal of general physiology.

5-HT3 Receptor MX Helix Contributes to Receptor Function

S. C. Lummis, D. Dougherty, Susanne M. Mesoy, 2022, ACS chemical neuroscience.

The Cationminus signpi Interaction.

J. C. Ma, D. Dougherty, 1997, Chemical reviews.

Tight, oriented binding of an aliphatic guest by a new class of water-soluble molecules with hydrophobic binding sites.

T. Shepodd, M. Petti, D. Dougherty, 1986, Journal of the American Chemical Society.

A Gating Charge Transfer Center in Voltage Sensors

R. MacKinnon, Alice Lee, X. Tao, 2010, Science.

Charge-transfer heptamethine dyes for NIR singlet oxygen generation.

D. Dougherty, J. Jarman, 2019, Chemical communications.

The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.

H. Lester, T. F. Miles, D. Dougherty, 2013, Biophysical journal.

Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes*

H. Lester, Nyssa L. Puskar, D. Dougherty, 2011, The Journal of Biological Chemistry.

Confirming the revised C-terminal domain of the MscL crystal structure.

H. Lester, D. Clayton, J. A. Maurer, 2008, Biophysical Journal.

Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel

H. Lester, A. Karschin, E. Slimko, 2001, The Journal of general physiology.

Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.

H. Lester, D. Dougherty, K. Daeffler, 2012, Journal of the American Chemical Society.

Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors

H. Lester, I. Rreza, D. Dougherty, 2014, ACS chemical biology.

From the Cover: Inaugural Article: Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

H. Lester, Angela P. Blum, D. Dougherty, 2010 .

1-Oxo-5-hydroxytryptamine: a surprisingly potent agonist of the 5-HT3 (serotonin) receptor.

Kiowa S. Bower, D. Dougherty, Sean M. A. Kedrowski, 2007, Organic letters.

Neurobiology: Snails, synapses and smokers

H. Lester, D. Dougherty, 2001, Nature.

Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry

H. Lester, M. P. Blanton, M. Shahgholi, 2003, Proceedings of the National Academy of Sciences of the United States of America.