G. Bommineni

发表

Rational modulation of the induced-fit conformational change for slow-onset inhibition in M. tuberculosis InhA

M. García-Díaz, P. Tonge, C. Simmerling, 2016 .

Rational Optimization of Diphenyl Ether Binding Kinetics to the Enoyl-ACP Reductase FabI1 from Burkholderia pseudomallei

P. Tonge, C. Kisker, R. Slayden, 2017 .

A [32P]-NAD+-based method to identify and quantitate long residence time enoyl-ACP reductase inhibitors

Ch Lai, P. Tonge, Lauren A. Spagnuolo, 2015 .

Mycobacterium Tuberculosis Condensing Enzyme and Drug Target from Mycolic Acid Precursors by KasA , a Structural Basis for the Recognition of Protein Structure and Folding

Martin J. Mueller, P. Tonge, C. Kisker, 2013 .

Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop

B. Jakobsen, D. Schümperli, P. Villiger, 2010, PLoS biology.

Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity

M. Wood, C. Vargeese, L. Apponi, 2022, Nucleic acids research.

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis *

Martin J. Mueller, P. Tonge, C. Kisker, 2013, The Journal of Biological Chemistry.

Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.

Anil K. Shukla, P. Tonge, T. Metz, 2015, Biochemistry.

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

K. G. Rajeev, M. Manoharan, M. Egli, 2018 .

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

K. G. Rajeev, M. Manoharan, M. Egli, 2018, Nucleic acids research.

during Infection to Bacterial Viability and Is Expressed Essential Carrier Protein Reductase Gene Is The Francisella tularensis FabI Enoyl-Acyl

P. Tonge, K. Brookman, C. Kingry, 2014 .

The Francisella tularensis FabI Enoyl-Acyl Carrier Protein Reductase Gene Is Essential to Bacterial Viability and Is Expressed during Infection

P. Tonge, K. Brookman, R. Slayden, 2012, Journal of bacteriology.

Thiolactomycin-based β-Ketoacyl-AcpM Synthase A (KasA) Inhibitors

P. Tonge, C. Simmerling, F. Picart, 2013, The Journal of Biological Chemistry.

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Journal of medicinal chemistry.

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor*

C. Sotriffer, P. Tonge, C. Kisker, 2014, The Journal of Biological Chemistry.

Modulating the Spectrum of FabI Inhibition by Pyridones 1 Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor *

C. Sotriffer, P. Tonge, C. Kisker, 2014 .

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

C. Sotriffer, B. Merget, P. Tonge, 2015, Biochemistry.

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Ch Lai, P. Tonge, C. Simmerling, 2016, Biochemistry.

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

Peter J. Tonge, Carlos Simmerling, Miguel Garcia-Diaz, 2014, ACS chemical biology.

Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin*

P. Tonge, C. Simmerling, C. Kisker, 2009, The Journal of Biological Chemistry.

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target

Martin J. Mueller, P. Tonge, C. Kisker, 2013 .

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

P. Tonge, C. Kisker, R. Slayden, 2017, Biochemistry.

Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.

M. García-Díaz, P. Tonge, C. Simmerling, 2015, Biochemistry.

A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors.

Ch Lai, P. Tonge, Lauren A. Spagnuolo, 2015, Analytical biochemistry.

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

M. García-Díaz, P. Tonge, C. Simmerling, 2014, ChemMedChem.

Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

Peter J. Tonge, Christoph A. Sotriffer, Weixuan Yu, 2013, Biochemistry.

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Tuberculosis.

RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.

K. G. Rajeev, M. Manoharan, M. Egli, 2018 .

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

M. García-Díaz, P. Tonge, C. Simmerling, 2014, ChemMedChem.

Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

C. Sotriffer, P. Tonge, C. Kisker, 2013, Biochemistry.

Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor*

P. Tonge, C. Kisker, R. Slayden, 2014 .