Yuan‐Fang Wang

发表

Design, Synthesis, Protein-ligand X-ray Structures and Biological Evaluation of a Series of Novel Macrocyclic HIV-1 Protease Inhibitors to Combat Drug-resistance

David D. Anderson, Arun K. Ghosh, I. Weber, 2010 .

HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.

Arun K. Ghosh, I. Weber, R. Harrison, 2022, Journal of molecular graphics & modelling.

Structure of choline oxidase in complex with the reaction product glycine betaine.

I. Weber, F. Salvi, G. Gadda, 2014, Acta crystallographica. Section D, Biological crystallography.

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

J. Louis, I. Weber, R. Harrison, 2006, Journal of molecular biology.

Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2020, ACS medicinal chemistry letters.

Crystallization and preliminary X-ray diffraction data for the carboxylesterase Est30 from Bacillus stearothermophilus.

I. Weber, A. Abdelal, Chung-Dar Lu, 2003, Acta crystallographica. Section D, Biological crystallography.

Surface-clean low-doped PdB/C as superior electrocatalysts toward ethanol oxidation in alkaline media

Zhi-gang Zhao, Chang Zhu, Yao-Yue Yang, 2018 .

New sesquiterpenes from the rhizomes of homalomena occulta.

G. Hou, Hongjuan Li, Wei Cong, 2016, Fitoterapia.

Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, Journal of medicinal chemistry.

Amprenavir complexes with HIV‐1 protease and its drug‐resistant mutants altering hydrophobic clusters

Irene T. Weber, Robert W. Harrison, Yuan-Fang Wang, 2010, The FEBS journal.

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Bioorganic & medicinal chemistry letters.

Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.

David D. Anderson, Heather B. Miller, Arun K. Ghosh, 2009, Journal of medicinal chemistry.

Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, Journal of medicinal chemistry.

A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

Irene T Weber, Masayuki Amano, Yuan-Fang Wang, 2007, Antimicrobial Agents and Chemotherapy.

Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

Irene T. Weber, Robert W. Harrison, Patra Volarath, 2003, Antimicrobial Agents and Chemotherapy.

Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran.

Arun K. Ghosh, J. Louis, I. Weber, 2013, Journal of medicinal chemistry.

Paraventricular nucleus is involved in the central pathway of adipose afferent reflex in rats.

Zhen Shi, Yuan‐Fang Wang, Gui-hua Wang, 2016, Canadian journal of physiology and pharmacology.

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2013, Journal of medicinal chemistry.

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

Arun K. Ghosh, I. Weber, R. Harrison, 2018, ACS omega.

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, ChemMedChem.

[Anthraquinones and triterpenoids from roots of Knoxia roxburghii].

G. Hou, Jingqi Han, Chun-Hua Wang, 2014, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

Probing Multidrug‐Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV‐1 Protease Inhibitors

Arun K. Ghosh, I. Weber, H. Mitsuya, 2010, ChemMedChem.

Removal of acid and direct dye by epichlorohydrin-dimethylamine: flocculation performance and floc aggregation properties.

B. Gao, Q. Yue, Zhonglian Yang, 2012, Bioresource technology.

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

I. Weber, Jenny J. Yang, Shen Tang, 2013, Acta crystallographica. Section D, Biological crystallography.

Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.

Irene T Weber, Robert W Harrison, Chung-Dar Lu, 2004, Journal of molecular biology.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Journal of medicinal chemistry.

Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2007, Journal of medicinal chemistry.

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV‐1 protease mutants with substrate analogs

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2005, The FEBS journal.

Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2007, Proteins.

Design, synthesis, and X-ray structure of substituted bis-tetrahydrofuran (bis-THF)-derived potent HIV-1 protease inhibitors

Arun K. Ghosh, I. Weber, H. Mitsuya, 2011 .

HIV Protease: Historical Perspective and Current Research

I. Weber, R. Harrison, Yuan‐Fang Wang, 2021, Viruses.

Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus

I. Weber, G. Gadda, D. Su, 2018, Proteins.

Structural and kinetic studies on the Ser101Ala variant of choline oxidase: catalysis by compromise.

I. Weber, G. Gadda, A. Orville, 2010, Archives of biochemistry and biophysics.

Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.

Arun K. Ghosh, I. Weber, Y. Takamatsu, 2023, European journal of medicinal chemistry.

Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2020, Journal of medicinal chemistry.

Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues

I. Weber, R. Harrison, J. Agniswamy, 2019, ACS omega.

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2017, Bioorganic & medicinal chemistry.

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, Journal of molecular biology.

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.

Irene T Weber, Yuan-Fang Wang, Debananda Das, 2017, Journal of medicinal chemistry.

Critical differences in HIV‐1 and HIV‐2 protease specificity for clinical inhibitors

Arun K. Ghosh, J. Louis, I. Weber, 2012, Protein science : a publication of the Protein Society.

HIV‐1 Protease: Role in Viral Replication, Protein–Ligand X‐Ray Crystal Structures and Inhibitor Design

I. Weber, Yuan‐Fang Wang, 2011 .

Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.

Irene T Weber, Yuan-Fang Wang, Arun K. Ghosh, 2008, Journal of medicinal chemistry.

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Journal of medicinal chemistry.

Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.

Arun K. Ghosh, I. Weber, R. Harrison, 2019, Biochemical and biophysical research communications.

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, European journal of medicinal chemistry.

Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Organic & biomolecular chemistry.

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

Arun K. Ghosh, I. Weber, R. Harrison, 2006, Journal of medicinal chemistry.

Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, European journal of biochemistry.

Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.

Arun K. Ghosh, I. Weber, J. Agniswamy, 2023, Bioorganic & medicinal chemistry letters.

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2016, Journal of medicinal chemistry.

Antiviral anthraquinones from the roots of Knoxia valerianoides

Jingqi Han, Chun-Hua Wang, Feng Zhao, 2015 .

The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.

J. Louis, I. Weber, R. Harrison, 2011, Biochemistry.

Combining mutations in HIV‐1 protease to understand mechanisms of resistance

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2002, Proteins.

Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps

J. Louis, I. Weber, R. Harrison, 2014, ACS chemical biology.

Immunodeficiency Virus In Vitro against Multi-PI-Resistant Human UIC-94017 ( TMC 114 ) with Potent Activity Nonpeptidic Protease Inhibitor ( PI )-Tetrahydrofuranylurethane-Containing bis Novel

Irene T. Weber, Robert W. Harrison, Patra Volarath, 2003 .

Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.

Arun K. Ghosh, I. Weber, R. Harrison, 2013, Journal of medicinal chemistry.

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.

J. Louis, I. Weber, R. Harrison, 2000, European journal of biochemistry.

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2006, Journal of molecular biology.

Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir

Arun K. Ghosh, I. Weber, H. Mitsuya, 2017, ChemMedChem.

Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features

C. Croce, I. Weber, R. Harrison, 2002, TheScientificWorldJournal.

Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.

David D. Anderson, Arun K. Ghosh, I. Weber, 2009, Journal of medicinal chemistry.

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies

Arun K. Ghosh, I. Weber, H. Mitsuya, 2019, ChemMedChem.

Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease.

I. Weber, R. Harrison, Chen-Hsiang Shen, 2012, Biochemistry.

Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.

Arun K. Ghosh, I. Weber, R. Harrison, 2012, Journal of medicinal chemistry.

Synthesis, Structural Characterization, Hirschfeld Surface Analysis and Photocatalytic CO2 Reduction of Yb(III) Complex with 4-Aacetylphenoxyacetic Acid and 1,10-Phenanthroline Ligands

X. Tai, Lihua Wang, Yuan‐Fang Wang, 2023, Bulletin of Chemical Reaction Engineering & Catalysis.

Probing Multidrug‐Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV‐1 Protease Inhibitors

Arun K. Ghosh, I. Weber, H. Mitsuya, 2010, ChemMedChem.

Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies.

Heather B. Miller, Arun K. Ghosh, I. Weber, 2008, Organic & biomolecular chemistry.

HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand

I. Weber, J. Agniswamy, S. Hattori, 2018 .

Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.

Arun K. Ghosh, I. Weber, R. Harrison, 2013, Journal of medicinal chemistry.

Design of gem‐Difluoro‐bis‐Tetrahydrofuran as P2 Ligand for HIV‐1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X‐ray Studies, and Biological Evaluation

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, ChemMedChem.

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

I. Weber, Jenny J. Yang, Shen Tang, 2013, Acta crystallographica. Section D, Biological crystallography.