Tsuneaki Ogata

发表

Potent antidiabetic effects of rivoglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, in obese diabetic rodent models.

M. Yachi, J. Ohsumi, K. Araki, 2009, Journal of pharmacological sciences.

Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.

S. Ito, Koji Matsumoto, Masakazu Hirouchi, 2015, ACS medicinal chemistry letters.

Discovery of novel SCD1 inhibitors: 5-alkyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] analogs.

J. Ohsumi, Y. Uto, T. Takagi, 2011, European journal of medicinal chemistry.

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.

J. Ohsumi, Y. Uto, N. Watanabe, 2010, Bioorganic & medicinal chemistry letters.

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.

M. Yamada, Y. Uto, N. Watanabe, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.

M. Yamada, J. Ohsumi, Y. Uto, 2010, European journal of medicinal chemistry.

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].

M. Yamada, J. Ohsumi, Y. Uto, 2010, Bioorganic & medicinal chemistry letters.

Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.

Koji Matsumoto, N. Watanabe, M. Inoue, 2014, Bioorganic & medicinal chemistry letters.

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization.

Hideki Yamamoto, J. Ohsumi, N. Watanabe, 2018, Bioorganic & medicinal chemistry.

A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis.

J. Ohsumi, Y. Uto, T. Takagi, 2013, Biological & pharmaceutical bulletin.

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.

Ryo Okuyama, Manabu Abe, Toshiyuki Takagi, 2009, Bioorganic & medicinal chemistry letters.

Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558.

Koji Matsumoto, Masakazu Hirouchi, N. Watanabe, 2015, Bioorganic & medicinal chemistry.