Stéphanie van Hoppe

发表

What next? Preferably development of drugs that are no longer transported by the ABCB1 and ABCG2 efflux transporters.

A. Schinkel, Stéphanie van Hoppe, 2017, Pharmacological research.

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Molecular pharmaceutics.

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability.

J. Beijnen, A. Schinkel, E. Wagenaar, 2018, Molecular pharmaceutics.

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

J. Schellens, J. Beijnen, A. Schinkel, 2016, Journal of pharmaceutical and biomedical analysis.

Targeting cancer cells with the natural compound obtusaquinone.

B. Tannous, C. Badr, Lee-Ann Tjon-Kon-Fat, 2013, Journal of the National Cancer Institute.

P-glycoprotein limits ribociclib brain exposure and CYP3A4 restricts its oral bioavailability.

H. Rosing, J. Beijnen, A. Schinkel, 2019, Molecular pharmaceutics.

P‐glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Pharmacological research.

Breast cancer resistance protein (BCRP/ABCG2) and P‐glycoprotein (P‐gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation☆

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Pharmacological research.

The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.

A. Schinkel, S. Durmuş, Alfred H Schinkel, 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Extrahepatic metabolism of ibrutinib

J. Beijnen, A. Schinkel, R. Masereeuw, 2020, Investigational New Drugs.

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein).

J. Beijnen, A. Schinkel, E. Wagenaar, 2019, Pharmacological research.

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice

U. Beuers, S. V. D. van de Graaf, A. Schinkel, 2017, Hepatology.

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction.

J. Schellens, J. Beijnen, A. Schinkel, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.