W. Billard

发表

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

W. Greenlee, J. Lachowicz, J. Clader, 2000, Bioorganic & medicinal chemistry letters.

Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites.

A. Barnett, W. Billard, L. Iorio, 1984, Life sciences.

Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.

C. Strader, J. Lachowicz, J. Clader, 2001, Life sciences.

SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals.

G. Carey, R. Watkins, V. Coffin, 2001, European journal of pharmacology.

The metabolism of chlorpheniramine maleate in the dog and rat.

S. Symchowicz, E. Peets, W. Billard, 1972, Archives internationales de pharmacodynamie et de therapie.

Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic.

R. Chapman, A. Barnett, R. Chipkin, 1988, The Journal of pharmacology and experimental therapeutics.

Relative activities of SCH 23390 and its analogs in three tests for D1/DA1 dopamine receptor antagonism.

L. I. Goldberg, A. Barnett, H. Ahn, 1986, European journal of pharmacology.

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.

W. Greenlee, J. Lachowicz, J. Clader, 2004, Bioorganic & medicinal chemistry.

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.

J. Lachowicz, J. Clader, S. Dugar, 2000, Bioorganic & medicinal chemistry letters.

Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.

J. Lachowicz, J. Tagat, Guowei Zhou, 2002, Bioorganic & medicinal chemistry letters.

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.

A. Barnett, W Billard, V Ruperto, 1984, Life sciences.

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.

J. Lachowicz, K. Cox, V. Coffin, 2002, Bioorganic & Medicinal Chemistry Letters.

Sulfhydryl Reactivity: Mechanism of Action of Several Antiviral Compounds—Selenocystine, 4-(2-Propinyloxy)-β-Nitrostyrene, and Acetylaranotin

E. Peets, W. Billard, William Billard, 1974, Antimicrobial Agents and Chemotherapy.

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

W. Greenlee, J. Lachowicz, J. Clader, 2001, Bioorganic & medicinal chemistry letters.

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.

C. Strader, J. Lachowicz, J. Clader, 2001, Farmaco.

Benzylidene ketal derivatives as M2 muscarinic receptor antagonists.

J. Lachowicz, V. Coffin, M. Cohen-Williams, 2000, Bioorganic & medicinal chemistry letters.

Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data.

R. Mcquade, W. Billard, H. Binch, 1995, The Journal of pharmacology and experimental therapeutics.

Selective affinity of the benzodiazepines quazepam and 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand.

A. Barnett, R. Chipkin, W. Billard, 1988, Life sciences.

Relationship of yeast-injection induced changes in brain Met-enkephalin and analgesia

A. Barnett, R. Chipkin, W. Billard, 1982, Peptides.

Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor.

W. Kreutner, R. Chipkin, W. Billard, 1984, European journal of pharmacology.

Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.

J. Lachowicz, G. Zhou, J. Kozlowski, 2000, Bioorganic & medicinal chemistry letters.

Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.

W. Greenlee, J. Lachowicz, J. Clader, 2002, Journal of Medicinal Chemistry.

Benzazepines: structure-activity relationships between D1 receptor blockade and selected pharmacological effects.

A. Barnett, W. Billard, L. Iorio, 1986, Advances in experimental medicine and biology.