V. Ruperto

发表

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

W. Greenlee, J. Lachowicz, J. Clader, 2000, Bioorganic & medicinal chemistry letters.

SCH 39166, a novel dopamine D1 receptor antagonist: In vitro investigation of its glucuronidation and potential species differences

A. Barnett, C. Tedford, V. Coffin, 1992 .

Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.

C. Strader, J. Lachowicz, J. Clader, 2001, Life sciences.

Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists.

D. Doller, R. Mcquade, M. Czarniecki, 1999, Bioorganic & medicinal chemistry letters.

SCH 57790: a novel M2 receptor selective antagonist.

C. Strader, J. Lachowicz, J. Clader, 1999, Life sciences.

Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists.

W. Greenlee, J. Lachowicz, R. Mcquade, 2001, Bioorganic & medicinal chemistry letters.

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.

J. Lachowicz, J. Clader, S. Dugar, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.

J. Lachowicz, T. Asberom, J. Tagat, 2002, Bioorganic & medicinal chemistry letters.

Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.

J. Lachowicz, J. Tagat, Guowei Zhou, 2002, Bioorganic & medicinal chemistry letters.

Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations.

D. Doller, R. Mcquade, S. Chackalamannil, 2004, Bioorganic & medicinal chemistry letters.

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.

A. Barnett, W Billard, V Ruperto, 1984, Life sciences.

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.

J. Lachowicz, K. Cox, V. Coffin, 2002, Bioorganic & Medicinal Chemistry Letters.

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

W. Greenlee, J. Lachowicz, J. Clader, 2001, Bioorganic & medicinal chemistry letters.

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.

C. Strader, J. Lachowicz, J. Clader, 2001, Farmaco.

Benzylidene ketal derivatives as M2 muscarinic receptor antagonists.

J. Lachowicz, V. Coffin, M. Cohen-Williams, 2000, Bioorganic & medicinal chemistry letters.

Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.

J. Lachowicz, G. Zhou, J. Kozlowski, 2000, Bioorganic & medicinal chemistry letters.

Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.

W. Greenlee, J. Lachowicz, J. Clader, 2002, Journal of Medicinal Chemistry.

Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.

W. Greenlee, J. Lachowicz, A. Palani, 2004, Bioorganic & medicinal chemistry letters.

Determination of plasma and brain concentrations of SCH 39166 and their correlation to conditioned avoidance behavior in rats

R. Mcquade, C. Tedford, V. Coffin, 2005, Psychopharmacology.