R. Cornett

Pharmacokinetics, metabolism and toxicology of dichloroacetate.

P. Stacpoole, M. James, G. Henderson, 1998, Drug metabolism reviews.

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

M. Grompe, P. Stacpoole, M. James, 2003, Biochemical pharmacology.

Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats.

P. Stacpoole, M. James, G. Henderson, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.

P. Stacpoole, M. James, G. Henderson, 1999, Biochemical and biophysical research communications.

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

P. Stacpoole, M. James, N. Davydova, 1998, Drug metabolism and disposition: the biological fate of chemicals.