Angela A. Liu

发表

8,9-methylenedioxybenzo[i]phenanthridines: topoisomerase I-targeting activity and cytotoxicity.

E. LaVoie, Leroy F. Liu, Tsai-Kun Li, 2003, Bioorganic & medicinal chemistry.

Mutations of human topoisomerase IIα affecting multidrug resistance and sensitivity

T. Hsieh, Leroy F. Liu, Huimin Wang, 1999 .

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity.

E. LaVoie, J. E. Rice, D. S. Pilch, 2010, Bioorganic & medicinal chemistry letters.

Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).

E. LaVoie, Leroy F. Liu, Y. Tsai, 2008, Bioorganic & medicinal chemistry.

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.

E. LaVoie, Shejin Zhu, Alexander L. Ruchelman, 2004, Bioorganic & medicinal chemistry letters.

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.

A. Ray, E. LaVoie, Jin-Ming Yang, 2003, Bioorganic & medicinal chemistry.

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Peter J Houghton, Parima Daroui, P. Houghton, 2003, Cancer research.

Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.

E. LaVoie, Alexander L. Ruchelman, Leroy F. Liu, 2003, Journal of medicinal chemistry.

Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors.

Ruiyuan Cao, Jun-hai Xiao, Song Li, 2017, Bioorganic & medicinal chemistry letters.

Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents

E. LaVoie, Alexander L. Ruchelman, N. Zhou, 2003 .

Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.

E. LaVoie, Leroy F. Liu, Tsai-Kun Li, 2003, Bioorganic & medicinal chemistry.

11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.

A. Ray, E. LaVoie, Jin-Ming Yang, 2004, Bioorganic & medicinal chemistry.

Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.

E. LaVoie, J. E. Rice, D. S. Pilch, 2010, Journal of medicinal chemistry.

5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

Nai Zhou, Peter J Houghton, P. Houghton, 2005, Journal of medicinal chemistry.

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.

A. Ray, E. LaVoie, Jin-Ming Yang, 2002, Bioorganic & medicinal chemistry letters.

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.

E. LaVoie, Shejin Zhu, Alexander L. Ruchelman, 2004, Bioorganic & medicinal chemistry letters.

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.

E. LaVoie, J. Kerrigan, Alexander L. Ruchelman, 2004, Bioorganic & medicinal chemistry.

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation.

E. LaVoie, D. S. Pilch, J. Kerrigan, 2003, Bioorganic & medicinal chemistry letters.

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.

E. LaVoie, Shejin Zhu, Alexander L. Ruchelman, 2006, Bioorganic & medicinal chemistry.

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.

E. LaVoie, Shejin Zhu, Alexander L. Ruchelman, 2005, Bioorganic & Medicinal Chemistry.

2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents.

E. LaVoie, Leroy F. Liu, Tsai-Kun Li, 2003, Bioorganic & medicinal chemistry.

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency.

E. LaVoie, J. E. Rice, D. S. Pilch, 2008, Bioorganic & medicinal chemistry letters.

G-quadruplexes induce apoptosis in tumor cells.

Chao-Po Lin, D. S. Pilch, C. M. Barbieri, 2006, Cancer research.

Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2008, European journal of medicinal chemistry.

Biotransformation of the Chemopreventive Agent 2 (cid:1) ,4 (cid:1) ,4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases

J. Pezzuto, H. Cao, Yan Luo, 2008 .

Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.

E. LaVoie, Leroy F. Liu, Tsai-Kun Li, 2003, Bioorganic & medicinal chemistry.

The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis

J. Kang, Angela A. Liu, 2013, Cancer and Metastasis Reviews.

Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)

G. Knipp, P. Sinko, A. Liu, 2002, Antimicrobial Agents and Chemotherapy.

Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death*

Leroy F. Liu, S. Desai, Tsai-Kun Li, 2004, Journal of Biological Chemistry.

Structure activity of topoisomerase i poisons related to hoechst 33342

E. LaVoie, Qun Sun, Leroy F. Liu, 1994 .

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2009, Bioorganic & medicinal chemistry.

Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2009, European journal of medicinal chemistry.

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2008, Bioorganic & medicinal chemistry.

Substituted 2,5′-Bi-1H-benzimidazoles: Topoisomerase I Inhibition and Cytotoxicity.

B. Gatto, E. LaVoie, Leroy F. Liu, 1996 .

Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.

E. LaVoie, Leroy F. Liu, Y. Tsai, 2008, Bioorganic & medicinal chemistry.

Cytotoxicity of 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-Indeno[1,2-c]isoquinolin-5,11-diones in Tumor Cells Sensitive and Resistant to Camptothecin Analogs

Alexander L. Ruchelman, N. Zhou, Leroy F. Liu, 2004 .

Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity

E. LaVoie, J. E. Rice, D. S. Pilch, 2013, Molecules.

Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity.

E. LaVoie, J. E. Rice, D. S. Pilch, 2013, Bioorganic & medicinal chemistry.

Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.

B. Gatto, C. Yu, A. Liu, 1996, Journal of medicinal chemistry.

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

J. Wang, C. Croce, J. Whang‐Peng, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Abstract C76: Oxazole‐containing macrocyles as selective G‐quadruplex stabilizers

E. LaVoie, J. E. Rice, D. S. Pilch, 2009 .

The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis

J. Kang, Angela A. Liu, 2012, Cancer and Metastasis Reviews.