U. Andrae

发表

The liver as origin and target of reactive intermediates exemplified by the progesterone derivative, cyproterone acetate.

J. Topinka, I. Neumann, T. Wolff, 1996, Advances in experimental medicine and biology.

Sulfotransferases: genetics and role in toxicology.

H. Glatt, C. Falany, W. Meinl, 2000, Toxicology letters.

Comparison of the continuous rat hepatoma cell line 2sFou with primary rat hepatocyte cultures for the induction of DNA repair synthesis by nitrosamines, benzo[a]pyrene and hydroxyurea.

F. Wiebel, U. Andrae, S. Rossberger, 1987, Mutation research.

Recommendations for the performance of UDS tests in vitro and in vivo.

H. Mori, C. Mcqueen, G. Brambilla, 1994, Mutation research.

2-Chlorobenzylidene malonitrile (CS) causes spindle disturbances in V79 Chinese hamster cells.

M. Bauchinger, E. Schmid, K. Ziegler-Skylakakis, 1989, Mutation research.

J. Singh, K. Ziegler-Skylakakis, U. Andrae, 1985, Toxicology letters.

Methods in Toxicology

T. Singer, K. Ulm, P. Kasper, 2008 .

Background DNA repair synthesis in rat hepatocyte cultures used for genotoxicity testing.

U. Andrae, S. Rossberger, 1987, Toxicology in vitro : an international journal published in association with BIBRA.

Propane 2-nitronate is more rapidly denitrified and is more genotoxic than 2-nitropropane in cultured rat hepatoma cells.

U. Andrae, C. Dalke, 1992, Toxicology letters.

Threshold levels in toxicology: significance of inactivation mechanisms.

W. Göggelmann, K. Summer, H. Greim, 1981, Advances in Experimental Medicine and Biology.

S‐oxygenation of thiourea results in the formation of genotoxic products

K. Ziegler-Skylakakis, U. Andrae, J.F. Pan, 1998, Environmental and molecular mutagenesis.

Reactive intermediates of xenobiotics in thyroid: formation and biological consequences.

U. Andrae, 1996, Advances in experimental medicine and biology.

TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.

L. Hieber, J. Lichtmannegger, Carola Eberhagen, 2013, Toxicology.

Quantitative phosphoproteomic analysis of early alterations in protein phosphorylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

M. Larsen, F. Eckardt-Schupp, Carola Eberhagen, 2013, Journal of proteome research.

Quantitative analysis of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐induced proteome alterations in 5L rat hepatoma cells using isotope‐coded protein labels

Friedrich Lottspeich, Thomas Meindl, Josef Kellermann, 2006, Proteomics.

Thiourea induces DNA repair synthesis in primary rat hepatocyte cultures and gene mutations in V79 Chinese hamster cells

K. Ziegler-Skylakakis, U. Andrae, S. Rossberger, 1985, Archives of Toxicology.

Validity of Short-Term Tests to Detect Carcinogenic Chemicals

W. Göggelmann, K. Summer, H. Greim, 1987 .

Application, limitations and research requirements of in vitro test systems in toxicology.

H. Greim, L. Schwarz, U. Forster, 1986, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

DNA repair synthesis induced by N-hydroxyurea, acetohydroxamic acid, and N-hydroxyurethane in primary rat hepatocyte cultures: comparative evaluation using the autoradiographic and the bromodeoxyuridine density-shift method.

U. Andrae, S. Rossberger, 1985, Mutation research.

Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyurea.

U. Andrae, 1984, Biochemical and biophysical research communications.

Analysis of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Proteome Changes in 5L Rat Hepatoma Cells Reveals Novel Targets of Dioxin Action Including the Mitochondrial Apoptosis Regulator VDAC2*S

H. Sarioglu, Markus Haberger, M. Wormke, 2008, Molecular & Cellular Proteomics.

Recommendations for the categorization of germ cell mutagens

R. Thier, H. Neumann, D. Wild, 2000, International archives of occupational and environmental health.

Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells.

H. Greim, I. Neumann, L. Schwarz, 1992, Carcinogenesis.

Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.

H. Glatt, W. Meinl, M. Coughtrie, 2000, Carcinogenesis.

Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases.

H. Glatt, W. Meinl, M. Coughtrie, 1999, Mutation research.

Sulfotransferase-mediated genotoxicity of propane 2-nitronate in cultured ovine seminal vesicle cells.

G. Degen, U. Andrae, P. Kreis, 1998, Mutation research.

The insecticide buprofezin induces morphological transformation and kinetochore-positive micronuclei in cultured Syrian hamster embryo cells in the absence of detectable DNA damage.

P. Ostrosky-Wegman, D. Schiffmann, L. Herrera, 1993, Mutation research.

Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds.

L. Schwarz, U. Andrae, 1981, Cancer letters.

Induction of DNA repair replication by hydroxyurea in human lymphoblastoid cells mediated by liver microsomes and NADPH.

H. Greim, U. Andrae, 1979, Biochemical and biophysical research communications.

Mutagenicity and cytotoxicity of 2-chlorobenzylidene malonitrile (CS) and metabolites in V79 Chinese hamster cells

K. Summer, K. Ziegler-Skylakakis, U. Andrae, 2004, Archives of Toxicology.

Mutagenicity of hydrogen peroxide in V79 Chinese hamster cells.

K. Ziegler-Skylakakis, U. Andrae, 1987, Mutation research.

2-Nitropropane induces DNA repair synthesis in rat hepatocytes in vitro and in vivo.

K. Summer, J. Lichtmannegger, U. Andrae, 1988, Carcinogenesis.

Radical intermediates during the oxidation of nitropropanes. The formation of NO2 from 2-nitropropane, its reactivity with nucleosides, and implications for the genotoxicity of 2-nitropropane.

K. Stettmaier, W. Bors, C. Michel, 1993, Chemical research in toxicology.

SCCP (Scientific Committee on Consumer Products) / SCHER (Scientific Committee on Health& Environment Risks) / SCENIHR (Scientific Committee on Emerging and Newly- Identified Health Risks) opinion on: Risk assessment methodologies and approaches for genotoxic and carcinogenic substances

Marco Vighi, Matti Viluksela, Marco Nuti, 2009 .

DNA-damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver.

J. Topinka, B. Binková, I. Neumann, 1995, Carcinogenesis.

DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate.

A. Martelli, S. Fazio, G. Brambilla, 1995, Carcinogenesis.

Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

J. Topinka, T. Wolff, L. Schwarz, 1993, Carcinogenesis.

Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.

E. Roscher, K. Ziegler-Skylakakis, U. Andrae, 1990, Mutagenesis.

DNA repair synthesis induced by azo dyes in primary rat hepatocyte cultures using the bromodeoxyuridine density-shift method.

L. Schwarz, J. Palus, U. Andrae, 1995, International journal of occupational medicine and environmental health.

Microsome- and hepatocyte-mediated mutagenicity of hydroxyurea and related aliphatic hydroxamic acids in V79 Chinese hamster cells.

L. Schwarz, K. Ziegler-Skylakakis, U. Andrae, 1985, Mutation research.

Dichloromethane is not genotoxic in isolated rat hepatocytes

T. Wolff, U. Andrae, 1983, Archives of Toxicology.

How relevant are high doses in mutagenicity and carcinogenicity studies in animals

W. Göggelmann, K. Summer, H. Greim, 1981 .