H. Walton

发表

CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).

P. Sinclair, N. Gorman, J. Sinclair, 1998, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney.

P. Sinclair, N. Gorman, J. Sinclair, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes.

P. Sinclair, J. Jacobs, N. Gorman, 1997, Toxicology and applied pharmacology.

IDENTIFICATION OF CYP 1 A 5 AS THE CYP 1 A ENZYME MAINLY RESPONSIBLE FOR UROPORPHYRINOGEN OXIDATION INDUCED BY AH RECEPTOR LIGANDS IN CHICKEN LIVER AND KIDNEY

P. Sinclair, N. Gorman, J. Sinclair, 1997 .

Ascorbic acid inhibits chemically induced uroporphyria in ascorbate‐requiring rats

P. Sinclair, N. Gorman, J. Sinclair, 1995, Hepatology.

Uroporphyria in Hfe mutant mice given 5‐aminolevulinate: A new model of Fe‐mediated porphyria cutanea tarda

N. Andrews, P. Sinclair, G. Gerhard, 2001, Hepatology.

Uroporphyria in mice: Thresholds for hepatic CYP1A2 and iron

D. Nebert, P. Sinclair, T. Dalton, 2002, Hepatology.

Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.

D. Nebert, F. Gonzalez, P. Sinclair, 2000, Archives of biochemistry and biophysics.

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

D. Nebert, P. Sinclair, T. Dalton, 2000, Toxicology and applied pharmacology.

Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.

P. Sinclair, N. Gorman, J. Sinclair, 1999, Biochemical pharmacology.

Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.

P. Sinclair, J. Jacobs, N. Gorman, 1998, Toxicology.

Effects of diphenyl ether herbicides on porphyrin accumulation by cultured hepatocytes.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 1992, Journal of biochemical toxicology.

Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.

P. Sinclair, J. Sinclair, S. Wood, 1998, Archives of biochemistry and biophysics.

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

D. Nebert, P. Sinclair, T. Dalton, 1998, The Biochemical journal.

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

S. Wrighton, F. Gonzalez, E. Jeffery, 2000, Toxicology and applied pharmacology.

Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 1994, Cellular and molecular biology.

Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes.

P. Sinclair, J. Jacobs, J. Sinclair, 1999, Archives of biochemistry and biophysics.

Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes.

P. Sinclair, J. Jacobs, J. Sinclair, 1998, Toxicology and applied pharmacology.

Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.

P. Sinclair, J. Jacobs, N. Gorman, 2000, Toxicology and applied pharmacology.

Uroporphyrinogen oxidation catalyzed by human cytochromes P450.

U. Fuhr, P. Sinclair, N. Gorman, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Release of Cr(III) from Cr(III) picolinate upon metabolic activation.

P. Sinclair, H. Walton, C. Kelley, 2001, Journal of hazardous materials.