T. Andree

发表

Preclinical profile of the pyrimidinylpiperazinyl imide compound WY‐47,846: A potential anxiolytic

J. Haskins, M. Abou-Gharbia, J. Moyer, 1989 .

The dopamine D2 receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with l-dopa

J. Kehne, D. Hoffman, P. Jenner, 2009, Journal of Neural Transmission.

Phosphorus analogues of gamma-aminobutyric acid, a new class of anticonvulsants.

S. Enna, V. Li, E. Karbon, 1984, Journal of medicinal chemistry.

Is ecto-5'-nucleotidase essential for stimulation of human lymphocytes? Evidence against a role of the enzyme as mitogenic lectin receptor.

U. Kummer, W. Gutensohn, T. Andree, 1987, Immunobiology.

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.

R. Nilakantan, G. Stack, A. Gilbert, 2004, Bioorganic & medicinal chemistry letters.

Biochemical and electrophysiological studies of the psychotropic compound, amperozide

J. Haskins, T. Andree, E. Muth, 1987, Brain Research Bulletin.

The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.

F. Liu, K. Marquis, P. Reinhart, 2005, Journal of neurochemistry.

Biochemical, neurophysiological, and behavioral effects of Wy‐45,233 and other identified metabolites of the antidepressant venlafaxine

J. Haskins, G. E. Husbands, J. Moyer, 1991 .

Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

B. Harrison, D. Huryn, C. Beyer, 2006, Journal of medicinal chemistry.

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

G. McGaughey, K. Marquis, J. Brennan, 1998, Bioorganic & medicinal chemistry letters.

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

K. Marquis, J. Brennan, M. Abou-Gharbia, 1997, Journal of medicinal chemistry.

The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.

F. Liu, K. Marquis, M. Bowlby, 2006, European journal of pharmacology.

Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.

L. Schechter, D. Smith, P. Zhou, 2002, Bioorganic & medicinal chemistry letters.

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

B. Harrison, J. Ellingboe, L. Schechter, 2010, Bioorganic & medicinal chemistry letters.

Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

B. Harrison, L. Schechter, D. Smith, 2006, Bioorganic & medicinal chemistry letters.

Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.

Richard E Mewshaw, L. Schechter, D. Smith, 2005, Bioorganic & medicinal chemistry letters.

Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity.

T. Coleman, A. Gilbert, L. Schechter, 2004, Bioorganic & medicinal chemistry letters.

Studies Toward the Discovery of the Next Generation of Antidepressants. Part 2. Incorporating a 5‐HT1A Antagonist Component into a Class of Serotonin Reuptake Inhibitors.

L. Schechter, D. Smith, P. Zhou, 2002 .

Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.

D. Smith, L. Schechter, P. Zhou, 2001, Bioorganic & medicinal chemistry letters.

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.

M. Day, T. Comery, S. Grauer, 2010, Journal of medicinal chemistry.

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.

M. James, G. Stack, G. E. Husbands, 1990, Journal of medicinal chemistry.

New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.

K. Marquis, J. Brennan, H. Mazandarani, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents.

G. McGaughey, K. Marquis, U. Patel, 1999, Journal of medicinal chemistry.

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.

G. McGaughey, K. Marquis, J. Brennan, 1999, Journal of medicinal chemistry.

Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

B. Harrison, C. Beyer, G. Stack, 2009, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents.

J. Haskins, U. Patel, M. Abou-Gharbia, 1989, Journal of medicinal chemistry.

Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.

B. Harrison, Minsheng Zhang, A. Failli, 2008, Journal of medicinal chemistry.

Characteristics and specificity of phenelzine and benserazide as inhibitors of benzylamine oxidase and monoamine oxidase.

D. Clarke, T. Andree, 1982, Biochemical pharmacology.

Antipsychotic activity of substituted gamma-carbolines.

U. Patel, M. Abou-Gharbia, J. Moyer, 1987, Journal of medicinal chemistry.

The inhibition of glycogen synthase kinase 3β by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aβ peptides

K. Marquis, F. Liu, P. Reinhart, 2005 .

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

Xiaojie Shi, Richard E Mewshaw, L. Schechter, 2004, Journal of medicinal chemistry.

Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.

B. Harrison, D. Huryn, L. Schechter, 2008, Bioorganic & medicinal chemistry.

From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes

D. Deecher, L. Schechter, D. Sloan, 2008, Psychoneuroendocrinology.

Differential Effect of Subchronic Treatment with Various Neuroleptic Agents on Serotonin2 Receptors in Rat Cerebral Cortex

H. Meltzer, M. Mikuni, J. Koenig, 1986, Journal of neurochemistry.

Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.

U. Patel, M. Abou-Gharbia, J. Moyer, 1988, Journal of medicinal chemistry.

Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.

B. Harrison, D. Huryn, W. Childers, 2005, Journal of medicinal chemistry.

Correlating Efficacy in Rodent Cognition Models with In Vivo 5-HT 1 A Receptor Occupancy by a Novel Antagonist

Hughes, M. Day, T. Comery, 2008 .

Correlating Efficacy in Rodent Cognition Models with in Vivo 5-Hydroxytryptamine1A Receptor Occupancy by a Novel Antagonist, (R)-N-(2-Methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane Carboxamide (WAY-101405)

M. Day, T. Comery, S. Grauer, 2008, Journal of Pharmacology and Experimental Therapeutics.

Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor

C. Beyer, M. Abou-Gharbia, D. Deecher, 2006, Journal of Pharmacology and Experimental Therapeutics.

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Z. Hughes, G. Stack, S. J. Sukoff Rizzo, 2009, The international journal of neuropsychopharmacology.

Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties

J. Barrett, K. Marquis, J. Buccafusco, 2005, Journal of Pharmacology and Experimental Therapeutics.

THIP analgesia: cross tolerance with morphine.

S. Enna, D. Kendall, T. Andree, 1983, Life sciences.

Differential and Synergistic Effects of Selective Norepinephrine and Serotonin Reuptake Inhibitors in Rodent Models of Pain

L. Leventhal, M. Brandt, K. Rogers, 2007, Journal of Pharmacology and Experimental Therapeutics.

Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist.

K. Marquis, J. Brennan, G. Stack, 2006, European Journal of Pharmacology.

Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.

B. Harrison, G. Stack, L. Schechter, 2007, Bioorganic & medicinal chemistry letters.

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

J. Brennan, J. Dwyer, R. Ring, 2013, Neuropharmacology.

The isolated perfused rat brain preparation in the study of monoamine oxidase and benzylamine oxidase. Lack of selective brain perfusion.

D. Clarke, T. Andree, 1981, Biochemical pharmacology.

New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.

G. McGaughey, K. Marquis, J. Brennan, 1998, Bioorganic & medicinal chemistry letters.

New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives

G. McGaughey, K. Marquis, J. Brennan, 1998 .

THE PRECLINICAL PHARMACOLOGICAL PROFILE OF VENLAFAXINE: A NOVEL ANTIDEPRESSANT AGENT

J. Haskins, G. E. Husbands, J. Moyer, 1992 .

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.

B. Harrison, W. Childers, Zhongqi Shen, 2010, Bioorganic & medicinal chemistry letters.

Neurochemical effects of kojic amine, a gabamimetic, and its interaction with benzylamine oxidase

S. Enna, J. Ferkany, T. Andree, 1981, Neuropharmacology.

Evidence for cholinergic muscarinic receptors on mediodorsal thalamic projections to the anterior cingulate cortex

S. Enna, J. Defrance, Z. Gottesfeld, 1983, Neuroscience Letters.

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.

K. Marquis, J. Brennan, J. Nelson, 1999, Bioorganic & medicinal chemistry letters.

Effect of Adrenocorticotropin Administration on β‐Adrenergic Receptor Adaptations in Rat Brain Cerebral Cortex

R. Duman, D. Kendall, S. Enna, 1984, Journal of neurochemistry.

Differential and Synergistic Effects of Selective Norepinephrine and Serotonin Reuptake Inhibitors in Rodent Models of Pain

L. Leventhal, M. Brandt, K. Rogers, 2007, Journal of Pharmacology and Experimental Therapeutics.

The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach.

M. Pausch, M. Popiolek, Yi-Ran Fan, 2008, Bioorganic & medicinal chemistry letters.

D2 receptor partial agonists: treatment of CNS disorders of dopamine function.

J. Kehne, J. Heinrich, T. Andree, 2008, Current topics in medicinal chemistry.