C. Grace

发表

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

K. Lindorff-Larsen, M. Cuneo, T. Mittag, 2020, bioRxiv.

Small molecule SJ572946 activates BAK to initiate apoptosis

Taosheng Chen, T. Moldoveanu, Z. Rankovic, 2022, iScience.

PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link

J. Schuetz, Junmin Peng, John Lynch, 2022, bioRxiv.

The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled receptors.

R. Riek, W. Vale, M. Perrin, 2006, Annals of the New York Academy of Sciences.

Common and divergent structural features of a series of corticotropin releasing factor-related peptides.

R. Riek, W. Vale, J. Rivier, 2007, Journal of the American Chemical Society.

Allosteric regulation through a switch element in the autophagy E2, Atg3

D. Klionsky, Yumei Zheng, B. Schulman, 2020, Autophagy.

Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.

R. Riek, J. Rivier, J. Reubi, 2008, Journal of medicinal chemistry.

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

R. Pappu, A. Holehouse, T. Mittag, 2020, Science.

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis

Taosheng Chen, F. Llambi, D. McNamara, 2018, Cell reports.

BID-induced structural changes in BAK promote apoptosis

D. Green, K. Gehring, F. Llambi, 2013, Nature Structural &Molecular Biology.

Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance.

S. M. Cowsik, C. Grace, 2011, Biopolymers.

Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.

J. Partridge, E. J. Enemark, C. Grace, 2015, Journal of molecular biology.

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.

D. Green, F. Llambi, A. Nourse, 2016, Molecular cell.

Metabolic activation of CaMKII by coenzyme A.

Robert A. Harris, D. Green, Taosheng Chen, 2013, Molecular cell.

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

D. Klionsky, Yumei Zheng, B. Schulman, 2019, Nature Communications.

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.

Jihun Lee, B. Schulman, T. Mittag, 2016, Journal of molecular biology.

Structural polymorphism in the N-terminal oligomerization domain of NPM1

Diana M. Mitrea, M. Madan Babu, M. Buljan, 2014, Proceedings of the National Academy of Sciences.

Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation.

R. Pappu, A. Holehouse, T. Mittag, 2016, Journal of the American Chemical Society.

Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.

D. Green, A. Hale, J. York, 2019, Cell chemical biology.

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

A. Hale, J. Bertin, S. Dixon, 2018, Molecular cell.

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.

R. Riek, W. Vale, J. Rivier, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A dual E3 mechanism for Rub1 ligation to Cdc53.

B. Schulman, R. Kriwacki, D. Duda, 2010, Molecular cell.

MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression

Edward C. Uberbacher, Philip F. LoCascio, Mark R. Wilkinson, 2016, PLoS Comput. Biol..

Distinct Structural and Functional Roles of Conserved Residues in the First Extracellular Domain of Receptors for Corticotropin-releasing Factor and Related G-protein-coupled Receptors*

R. Riek, G. Manning, S. Maji, 2007, Journal of Biological Chemistry.

Structural basis of BAK activation in mitochondrial apoptosis initiation

J. Seetharaman, D. McNamara, M. B. Waddell, 2022, Nature Communications.

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

Jie J. Zheng, S. Ogden, Ho-Jin Lee, 2013, Nature Communications.

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4

Asli N. Goktug, Jie J. Zheng, M. Relling, 2018, SLAS discovery : advancing life sciences R & D.

NMR Structure of the First Extracellular Domain of Corticotropin-releasing Factor Receptor 1 (ECD1-CRF-R1) Complexed with a High Affinity Agonist*

R. Riek, W. Vale, J. Rivier, 2010, The Journal of Biological Chemistry.

Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide.

R. Riek, J. Rivier, J. Gulyás, 2007, Biopolymers.

Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand

R. Riek, W. Vale, J. Rivier, 2007, Proceedings of the National Academy of Sciences.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

B. Kuhlman, M. Kirschner, J. Peters, 2016, Cell.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

J. Peters, H. Stark, P. Dube, 2015, Proceedings of the National Academy of Sciences.

Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical

B. Kuhlman, M. Kirschner, J. Peters, 2022 .

Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.

R. Riek, D. Hoyer, J. Rivier, 2009, Journal of medicinal chemistry.

Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes

E. Tajkhorshid, C. Rock, C. Subramanian, 2022, The Journal of biological chemistry.

Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins

E. Tajkhorshid, C. Rock, C. Subramanian, 2021, bioRxiv.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

J. Peters, H. Stark, S. Sidhu, 2019, Proceedings of the National Academy of Sciences.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

J. Peters, H. Stark, S. Sidhu, 2019, bioRxiv.

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

K. Lindorff-Larsen, J. Olsen, B. Kragelund, 2022, bioRxiv.

Supplemental Information Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex : RING Repurposing for Ubiquitin Chain Assembly

Jie J. Zheng, J. Peters, H. Stark, 2014 .

EM Structure of human APC/CCDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown

J. Peters, H. Stark, B. Schulman, 2013, Nature Structural &Molecular Biology.

Structural basis of BAK activation in mitochondrial apoptosis initiation

J. Seetharaman, D. McNamara, M. B. Waddell, 2022, Nature communications.

Use of Betidamino Acids in Drug Design

R. Riek, J. Rivier, J. Reubi, 2006 .

Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

R. Riek, J. Rivier, J. Reubi, 2005, Journal of medicinal chemistry.

Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment.

William J Welsh, S. M. Cowsik, Allyn C Howlett, 2007, Journal of structural biology.

NMR techniques for very large proteins and rnas in solution.

Roland Riek, R. Riek, A. Tzakos, 2006, Annual review of biophysics and biomolecular structure.

Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

A. Inoue, Benny J. Evison, N. Fujii, 2018, Journal of molecular biology.

Monitoring Ligand-Induced Protein Ordering in Drug Discovery.

D. Bashford, M. Dyer, R. Kriwacki, 2016, Journal of molecular biology.

Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists

R. Riek, W. Vale, J. Rivier, 2006 .

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

J. Schuetz, J. Peng, John Lynch, 2023, Communications biology.

PUMA Binding Induces Partial Unfolding within BCL-xL to Disrupt p53 Binding and Promote Apoptosis

Richard W. Kriwacki, Jerry E. Chipuk, Christy R. Grace, 2012, Nature chemical biology.

The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators.

R. Kriwacki, S. Otieno, C. Grace, 2011, Biophysical journal.

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

B. Schulman, R. Kriwacki, D. Duda, 2011, Nature Structural &Molecular Biology.

Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.

R. Riek, J. Rivier, J. Reubi, 2008, Journal of medicinal chemistry.

Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.

R. Riek, J. Rivier, J. Reubi, 2008, Biopolymers.

Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.

R. Riek, J. Rivier, J. Reubi, 2003, Journal of medicinal chemistry.

Pseudomultidimensional NMR by spin-state selective off-resonance decoupling.

R. Riek, C. Grace, 2003, Journal of the American Chemical Society.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

P. Dube, B. Schulman, A. Nourse, 2014, Molecules and Cells.

Em Structure of Human Apc/c Cdh1 -emi1 Reveals Multimodal Mechanism of E3 Ligase Shutdown Hhs Public Access

B. Schulman, R. Kriwacki, A. Nourse, 2022 .

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

H. Stark, S. Sidhu, B. Schulman, 2019, Proceedings of the National Academy of Sciences.

The Three‐Dimensional Structure of the N‐Terminal Domain of Corticotropin‐Releasing Factor Receptors

R. Riek, W. Vale, M. Perrin, 2006 .