Etsuro Watanabe

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).

M. Yoshikawa, Tsuyoshi Ishii, J. Yano, 2021, Journal of medicinal chemistry.

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

M. Klein, Biching Sang, T. Arita, 2016, Bioorganic & medicinal chemistry.

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.

M. Yoshikawa, K. Saikatendu, Y. Shimizu, 2018, Journal of medicinal chemistry.

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

M. Yoshikawa, M. During, J. Yano, 2020, Scientific Reports.

Exploring the stability of ligand binding modes to proteins by molecular dynamics simulations

Kai Liu, Hironori Kokubo, Etsurou Watanabe, 2017, Journal of Computer-Aided Molecular Design.

Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.

M. Yoshikawa, Tsuyoshi Ishii, J. Yano, 2022, Journal of medicinal chemistry.