R. Powers

发表

Exploring the potential of boronic acids as inhibitors of OXA‐24/40 β‐lactamase

Joshua M. Mitchell, R. Bonomo, M. Taracila, 2017, Protein science : a publication of the Protein Society.

Antibiotic Resistance Enzyme OXA-24 β-lactamase: Expression, Purification, and Optimization of Crystallization Conditions

Neil V. Klinger, J. Werner, R. Powers, 2013 .

Structural analysis of the Asn152Gly mutant of P99 cephalosporinase.

V. Cornish, S. Lefurgy, J. Ruble, 2012, Acta crystallographica. Section D, Biological crystallography.

Probing the Role of Asn 152 in the Class C β- lactamase AmpC

M. Anwar, D. Leonard, B. Docter, 2012 .

Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40

Joshua M. Mitchell, R. Bonomo, D. Leonard, 2022, The Journal of biological chemistry.

Structure-based efforts to optimize a non-β-lactam inhibitor of AmpC β-lactamase.

Robert P. Smart, William G. Schroeder, R. Powers, 2014, Bioorganic & medicinal chemistry.

Structure-based approach for binding site identification on AmpC beta-lactamase.

Brian K Shoichet, B. Shoichet, Rachel A Powers, 2002, Journal of medicinal chemistry.

Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii

R. Bonomo, E. Caselli, C. Romagnoli, 2014, Biochemistry.

Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C β-Lactamase.

R. Bonomo, E. Caselli, C. Romagnoli, 2017, ACS infectious diseases.

Class D β-lactamases: a reappraisal after five decades.

R. Bonomo, D. Leonard, R. A. Powers, 2013, Accounts of chemical research.

Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem.

R. Bonomo, D. Leonard, Kyle D. Schneider, 2011, Journal of molecular biology.

The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.

M. E. Karpen, R. Bonomo, D. Leonard, 2009, Biochemistry.

Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.

Joshua M. Mitchell, R. Bonomo, T. Wymore, 2015, Biochemistry.

Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

R. Bonomo, Neil V. Klinger, D. Leonard, 2013, Antimicrobial Agents and Chemotherapy.

Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-Lactamase

Brian K. Shoichet, B. Shoichet, Federica Morandi, 2002 .

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase

R. Bonomo, E. Caselli, P. Rather, 2020, ACS infectious diseases.

Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors.

R. Bonomo, E. Caselli, C. Romagnoli, 2017, ACS infectious diseases.

Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase

Maria Paola Costi, B. Shoichet, E. Caselli, 2001 .

Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.

B. Shoichet, E. Caselli, F. Prati, 2001, Chemistry & biology.

Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog

R. Bonomo, E. Caselli, F. Prati, 2020, Antimicrobial Agents and Chemotherapy.

The complexed structure and antimicrobial activity of a non‐β‐lactam inhibitor of AmpC β‐lactamase

Jesús Blázquez, Fernando Baquero, B. Shoichet, 2008, Protein science : a publication of the Protein Society.

Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.

B K Shoichet, B. Shoichet, E. Caselli, 2001, Biochemistry.

Structure-based design and in-parallel synthesis of inhibitors of AmpC L-lactamase

B. Shoichet, E. Caselli, M. Negri, 2001 .

Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors

B. Shoichet, E. Caselli, M. Costi, 2001 .

A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii

D. Fouts, L. Brinkac, R. Bonomo, 2020, Diagnostic Microbiology and Infectious Disease.

Sulfonamidoboronic Acids as “Cross-Class” Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii

R. Bonomo, E. Caselli, K. Hujer, 2023, Antibiotics.

Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.

R. Bonomo, M. Taracila, D. Leonard, 2018, The Biochemical journal.

The structure of a doripenem‐bound OXA‐51 class D β‐lactamase variant with enhanced carbapenemase activity

Z. Wawrzak, A. Szarecka, Zachary L. Klamer, 2016, Protein science : a publication of the Protein Society.

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum

R. Bonomo, E. Caselli, K. Hujer, 2023, Journal of medicinal chemistry.

Structural and Functional Aspects of Extended-Spectrum AmpC Cephalosporinases.

R. Powers, 2016, Current drug targets.

Structural Origins of Oxacillinase Specificity in Class D β-Lactamases

R. Bonomo, D. Leonard, Cynthia M. June, 2013, Antimicrobial Agents and Chemotherapy.

Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.

Joshua M. Mitchell, R. Bonomo, T. Wymore, 2015, Biochemistry.