J. Degraw

发表

Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase.

C. Mitoma, W. Skinner, M. Cory, 1967, Journal of medicinal chemistry.

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

F. Sirotnak, D. M. Moccio, L. J. Goutas, 2004, Cancer Chemotherapy and Pharmacology.

Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.

F. Sirotnak, D. M. Moccio, P. Chello, 1982, Cancer treatment reports.

New folate analogs of the 10-deaza-aminopterin series

F. Sirotnak, D. M. Moccio, L. J. Goutas, 2004, Cancer Chemotherapy and Pharmacology.

Potential histidine decarboxylase inhibitors. 1. alpha- and beta-substituted histidine analogues.

H. Johnson, M. Ellis, J. Degraw, 1977, Journal of medicinal chemistry.

Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.

F. Sirotnak, F. Schmid, J. Degraw, 1989, Cancer research.

Synthesis and Antitumor Activity of 10‐Propargyl‐10‐deazaaminopterin ( VII).

F. Sirotnak, J. Degraw, J. R. Piper, 1994 .

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.

F. Sirotnak, J. Degraw, J. R. Piper, 1993, Journal of medicinal chemistry.

New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

F. Sirotnak, F. Schmid, J. Degraw, 1985, Cancer treatment reports.

Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.

F. Sirotnak, R. Kisliuk, Y. Gaumont, 1990, Journal of medicinal chemistry.

THE SYNTHESIS AND PHARMACOLOGICAL ACTION OF TREMETONE.

W. Bonner, J. Degraw, V. Shah, 1963, Journal of medicinal chemistry.

Ketones from “white snakeroot” eupatorium urticaefolium

W. Bonner, J. Degraw, 1962 .

Synthesis of 5,10-dideazaminopterin

J. Lawson, H. Tagawa, R. Kisliuk, 1986 .

An alternate synthesis of 6-substituted-5-deazapteridines

J. Degraw, Hiroaki Tagawa, 1982 .

Potential antileprotic agents. 3. Inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines.

J. Degraw, W. T. Colwell, V. Brown, 1974, Journal of medicinal chemistry.

Antimicrobial activity of 8-deazafolic acid.

R. Kisliuk, Y. Gaumont, C. Baugh, 1974, Journal of medicinal chemistry.

Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.

J. Degraw, W. T. Colwell, P. H. Christie, 1992, Journal of medicinal chemistry.

Potential Anticancer Agents.1 IX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. I

L. Goodman, B. Baker, J. Degraw, 1958 .

The synthesis of racemic tremetone

W. Bonner, D. M. Bowen, J. Degraw, 1963 .

Synthesis and reactions of 4,6‐dimethoxyindole, an unusual indole system

W. Skinner, J. Degraw, V. Brown, 1969 .

Potential Anticancer Agents.1 LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

L. Goodman, B. Baker, B. Weinstein, 1962 .

An improved method for O-demethylation of codeine.

J. Lawson, J. Degraw, 1977, Journal of medicinal chemistry.

Potential Anticancer Agents.1 XLII. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. III. An Improved Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydrofolic Acid

L. Goodman, B. Baker, J. Degraw, 1961 .

Potential Anticancer Agents.1XXIV. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. II.

L. Goodman, B. Baker, J. Degraw, 1959 .

The preparation and reduction of 5‐cyano‐3‐indolylketones. Synthesis of 5‐cyanotryptamines

W. Skinner, J. Degraw, J. Kennedy, 1966 .

Synthesis of biopterin‐8a‐13C

I. Uemura, J. Degraw, V. Brown, 1979 .

α-Acetoxy and α-halomethylketones from acyloxosulfonium ylides

M. Cory, J. Degraw, 1968 .

Investigation of the grewe codeine method. Attempts to achieve a practical synthesis

M. Cory, J. Degraw, J. Christensen, 1974 .

2-amino-4-hydroxy-6-arylaminoethylpteridines as potential antimalarial agents.

R. Kisliuk, Y. Gaumont, M. Cory, 1971, Journal of Medicinal Chemistry.

Synthesis of mevalonolactone-2,3-13C2

I. Uemura, J. Degraw, 1979 .

Reaction of indolylmagnesium bromide and chloromethylpyridines. Synthesis of skatylpyridines and piperidines

W. Skinner, J. Degraw, J. Kennedy, 1966 .

Potential Anticancer Agents.1 LXXIV. Alkylating Agents Derived from Indole. III. Synthesis of Some Indolealkanoic Acid Nitrogen Mustards

L. Goodman, J. Degraw, 1962 .

Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.

W. Waud, R. Smith, J. Crase, 1997, Journal of Medicinal Chemistry.

Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.

W. Waud, C. Johnson, R. Smith, 1997, Journal of Medicinal Chemistry.

Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.

M. Sato, R. Kisliuk, Y. Gaumont, 1988, Journal of Medicinal Chemistry.

Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines.

J. Lawson, G. Loew, E. Uyeno, 1978, Journal of medicinal chemistry.

Synthesis of multilabeled histidine

J. Lawson, C. Soohoo, J. Degraw, 1977 .

THE SYNTHESIS OF 5-DIMETHYLAMINOINDOLE AND DERIVATIVES

J. Degraw, 1966 .

Synthesis and antifolate activity of 8,10‐dideazaminopterin

F. Sirotnak, R. Kisliuk, Y. Gaumont, 1982 .

Synthesis and evaluation of 8,10-dideazatetrahydrofolic acid and derivatives

F. Sirotnak, R. Kisliuk, Y. Gaumont, 1993 .

Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives.

F. Sirotnak, J. Degraw, J. R. Piper, 1988, Biochemical pharmacology.

Infrared spectra of silver salts to characterize carboxylic acids

W. Bonner, J. Degraw, 1962 .

Synthesis of hexalabeled thymine and thymidine

J. Lawson, J. Degraw, M. Anbar, 1975 .

Synthesis of multi carbon-13 labeled dexamethasone

M. Tanabe, E. Grange, T. Cairns, 1983 .

Synthesis of carbon-13 labeled 5-(diethylphosphono)-2-pentanone ethylene ketal, a reagent for synthesis of multi C-13 labeled steroids

T. Cairns, J. Degraw, P. H. Christie, 1982 .

Structure-activity studies of 3,4,5-trimethoxybenzamides. I. Variation of the amine function.

W. Skinner, H. Johnson, J. Degraw, 1969, Journal of medicinal chemistry.

Synthesis and antifolate activity of 10-deazaminopterin.

R. Kisliuk, Y. Gaumont, M. G. Nair, 1974, Journal of medicinal chemistry.

Synthesis of brevicomin, principal sex attractant of western pine beetle

R. Silverstein, J. Rodin, J. Degraw, 1971 .

Unexpected Formation of Highly Functionalized Dihydropyrans via Addition-Cyclization Reactions Between Dimethyl Oxoglutaconate and α,β-Unsaturated Hydrazones.

C. Thompson, M. Gajewski, J. Degraw, 2009, Tetrahedron letters.

Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1978, Cancer treatment reports.

Effect of organic compounds on reproductive processes. V. Alkylating agents derived from aryl-, aralkyl-, and cyclohexyl-methyl enediamines.

W. Skinner, M. Cory, T. E. Shellenberger, 1967, Journal of medicinal chemistry.

Synthesis of d-pilocarpine-N-14CH3.

E. Willis, J. Degraw, J. Engstrom, 1975, Journal of pharmaceutical sciences.

The Structures of Dehydrotremetone and Hydroxytremetone

W. Bonner, J. Degraw, 1962 .

The synthesis of 5- and 6-hydroxy-2-methylisoquinuclidine

J. Degraw, J. Kennedy, 1967 .

10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antitumor properties.

F. Sirotnak, F. Schmid, J. Degraw, 1987, NCI monographs : a publication of the National Cancer Institute.

The Synthesis of Homofolic Acid1—3

E. Acton, L. Goodman, A. Fujiwara, 1965 .

Substituted 1,2,3,4-tetrahydro- -carbolines

J. I. DeGraw, W. A. Skinner, W. Skinner, 1967 .

The synthesis of dihydrotremetone

W. Bonner, J. Degraw, 1962 .

Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.

N. Morrison, J. Degraw, W. T. Colwell, 1974, Journal of medicinal chemistry.

5-Nitro-and 5-aminogramines.

W. Skinner, J. Degraw, V. Brown, 1966, Journal of Medicinal Chemistry.

A Convenient Synthesis of N -CD 3 Labelled Tropine and Atropine

V. Fung, J. Degraw, 1976 .

ALKYLATING AGENTS DERIVED FROM INDOLES. IV. SYNTHESIS OF THE 5-NITROGEN MUSTARD OF INDOLE-3-CARBOXYLIC ACID.

L. Goodman, J. Degraw, 1964, Journal of medicinal chemistry.

Synthesis of methotrexate-1-15N and methotrexate-4-15NH2

J. Arnold, G. Roberts, K. Ryan, 1989 .

Synthesis of methotrexate‐3‐15N‐2‐15NH2. A convenient method for preparation of guanidiine‐15N3

J. Arnold, G. Roberts, K. Ryan, 1988 .

F. Sirotnak, A. Yagoda, D. M. Moccio, 1984, Cancer research.

Synthesis of 10‐deazapteroic and 11‐deazahomopteroic acids

R. Kisliuk, Y. Gaumont, J. Degraw, 1971 .

ToxÂ ¡ city , Elimination , and Metabolism of 10-Ethyl-lO-deazaaminopterin in Rats and Dogs 1

T. Chou, S. Sternberg, D. Niedzwiecki, 2006 .

Toxicity, elimination, and metabolism of 10-ethyl-10-deazaaminopterin in rats and dogs.

T. Chou, S. Sternberg, D. Niedzwiecki, 1987, Cancer research.

Synthesis of a new class of retinoid, 3H‐labelled TTNPB, 1 with a high specific activity

J. Degraw, H. H. Kaegi, S. Rhee, 1985 .

Histamine releasers. II. Synthesis of a trimer in the formaldehyde-p-methoxyphenethylamine series of histamine releasers.

W. Skinner, S. A. Ferguson, J. Degraw, 1966, Journal of medicinal chemistry.

Effect of charge shielding by nonpolar groups on the partitioning of quaternized amines.

J. Degraw, H. Johnson, P. Tsakotellis, 1970, Journal of pharmaceutical sciences.

Combination chemotherapy with a new folate analog: activity of 10-ethyl-10-deaza-aminopterin compared to methotrexate with 5-fluorouracil and alkylating agents against advanced metastatic disease in murine tumor models.

F. Sirotnak, F. Schmid, J. Degraw, 1987, Cancer treatment reports.

Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.

F. Sirotnak, H. Tagawa, R. Kisliuk, 1982, Journal of medicinal chemistry.

Convenient synthesis of 6-hydroxycoumarin

J. Degraw, P. Tsakotellis, 1969 .

VOLLSTAENDIGE SYNTH. VON 6-HYDROXYCUMARIN

J. Degraw, P. Tsakotellis, 1970 .

Synthesis of methyl 14-methyl-cis-8-hexadecenoate and 14-methyl-cis-8-hexadecen-1-ol. Sex attractant of Trogoderma inclusum

J. Rodin, J. Degraw, 1971 .

SYNTH. VON 14-METHYL-CIS-8-HEXADECENSAEUREMETHYLESTER UND 14-METHYL-CIS-8-HEXADECEN-1-OL, SEXUALLOCKSTOFFE AUS TROGODERMA INCLUSUM LECONTE

J. Rodin, J. Degraw, 1971 .

Potential antileprotic agents. 1. Inhibition of a model mycobacterial system by diaryl sulfones.

N. Morrison, J. Peters, J. Degraw, 1974, Journal of medicinal chemistry.

Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.

F. Sirotnak, R. Kisliuk, Y. Gaumont, 1984, Journal of medicinal chemistry.

Synthesis of morphine-d5 and codeine-d8

M. Anbar, J. Lawson, J. Degraw, 1976 .

Metabolic and toxicologic study of an artificial sweetener, oxime V.

E. Acton, C. Mitoma, D. Thomas, 1985, Drug and chemical toxicology.

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

J. Degraw, J. R. Piper, F. M. Sirotnak, 1998, Cancer Chemotherapy and Pharmacology.

Histamine releasers. I. Structure of the dimer formed from p-methoxy-N-methylphenethylamine and formaldehyde.

W. Skinner, N. E. Kontaxis, S. A. Ferguson, 1966, Journal of medicinal chemistry.

The Synthesis of Singly and Doubly 13C-Labeled Mevalonolactone

J. Lawson, M. Tanabe, R. Peters, 1975 .

Synthesis of edatrexate (2-13C-glutamate)

T. Jue, J. Degraw, W. T. Colwell, 1997 .