Michael P. Moazami

发表

ASO5-1 C9ORF72 Manuscript – 05Feb2021 POTENT MIXED BACKBONE ANTISENSE OLIGONUCLEOTIDE SAFELY SUPPRESSES EXPRESSION OF MUTANT C9ORF72 TRANSCRIPTS AND POLYDIPEPTIDES: FIRST IN HUMAN PILOT STUDY

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

Robert H. Brown, R. Bowser, D. Fabris, 2021, Nature Medicine.

Potent Mixed Backbone Antisense Oligonucleotide Safety Suppressed Expression of Mutant C9ORF72 Transcripts and Polypeptides: First in Human Pilot Study

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

Tomás C. Rodríguez, R. Maehr, A. Khvorova, 2022, Nucleic acids research.

Acid Gapmers and Conjugates Potently Silence ADAM 33 , an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

Y. Tan, H. Haitchi, J. Watts, 2019 .

Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

Y. Tan, H. Haitchi, J. Watts, 2017, Molecular therapy. Nucleic acids.

Locked Nucleic Acid gapmers and conjugates induce potent silencing of ADAM 33 , an asthma-associated metalloprotease with nuclear-localized mRNA

Y. Tan, H. Haitchi, J. Watts, 2017 .

Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

Robert H. Brown, J. Watts, K. Fitzgerald, 2021, bioRxiv.

Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs

A. Khvorova, D. Golebiowski, Andrew H Coles, 2018, Molecular Cancer Therapeutics.

Progress toward an amplifiable metabolic label for DNA: conversion of 4-thiothymidine (4sT) to 5-methyl-2′-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug

N. Rhind, J. Dekker, J. Watts, 2018, Canadian Journal of Chemistry.

Hybrid Aptamer-Molecularly Imprinted Polymer (aptaMIP) Nanoparticles from Protein Recognition-A Trypsin Model.

J. Watts, N. Turner, Mark V. Sullivan, 2021, Macromolecular bioscience.

RNase-H-mediated silencing in the CNS proves predictably nontrivial.

M. Wood, Michael P. Moazami, 2022, Med.

Quantifying and Mitigating Motor Phenotypes Induced by Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System Antisense Oligonucleotides in the Central Nervous System

M. Marosfoi, M. Motwani, P. M. Krishnamurthy, 2022 .