Alexandra Weiss

发表

ASO5-1 C9ORF72 Manuscript – 05Feb2021 POTENT MIXED BACKBONE ANTISENSE OLIGONUCLEOTIDE SAFELY SUPPRESSES EXPRESSION OF MUTANT C9ORF72 TRANSCRIPTS AND POLYDIPEPTIDES: FIRST IN HUMAN PILOT STUDY

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

Robert H. Brown, R. Bowser, D. Fabris, 2021, Nature Medicine.

Potent Mixed Backbone Antisense Oligonucleotide Safety Suppressed Expression of Mutant C9ORF72 Transcripts and Polypeptides: First in Human Pilot Study

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

A high-throughput screen to identify inhibitors of SOD1 transcription.

Robert H. Brown, R. Ferrante, W. Matson, 2012, Frontiers in bioscience.

Screening for inhibitors of the SOD1 gene promoter: Pyrimethamine does not reduce SOD1 levels in cell and animal models

Robert H. Brown, M. Glicksman, M. Huang, 2010, Neuroscience Letters.

Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

Robert H. Brown, J. Watts, K. Fitzgerald, 2021, bioRxiv.

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Robert H. Brown, D. A. Bosco, F. González-Nilo, 2022, Neuron.

Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor–Dependent Pathway That Increases Calcineurin Degradation

R. Karas, M. Aronovitz, R. Patten, 2009, Circulation research.

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

H. Horvitz, Robert H. Brown, L. Petrucelli, 2015, Neuron.

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Robert H. Brown, O. Peters, M. Freeman, 2018, Human molecular genetics.

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability.

Robert H. Brown, B. van Zundert, P. Rojas, 2013, Journal of neurophysiology.

Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease

Robert H. Brown, O. Peters, M. Freeman, 2021, Neurobiology of Disease.

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in Sod1 mutant mouse model of ALS

D. Lipscombe, M. Brodsky, Alper Kucukural, 2023, bioRxiv.

Quantifying and Mitigating Motor Phenotypes Induced by Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System Antisense Oligonucleotides in the Central Nervous System

M. Marosfoi, M. Motwani, P. M. Krishnamurthy, 2022 .

Mutant Sod1-expressing Astrocytes Release Toxic Factors That Trigger Motor Neuron Death

F. R. Mir, D. Gonzalez, Van Zundert, 2013 .

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

S. Almeida, Alexandra Weiss, F. Gao, 2023, Frontiers in neuroscience.